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The map label for this gene is tyrA [C]

Identifier: 28199252

GI number: 28199252

Start: 1590366

End: 1591487

Strand: Reverse

Name: tyrA [C]

Synonym: PD1368

Alternate gene names: 28199252

Gene position: 1591487-1590366 (Counterclockwise)

Preceding gene: 28199253

Following gene: 28199251

Centisome position: 63.16

GC content: 53.39

Gene sequence:

>1122_bases
GTGAGTGCGTCTCCCGTTGTTGGTATTGTCGGCAGTGCTGGTGCCTATGGACACTGGTTGGGACGCTTTCTGCGTGAGCG
TATGGACTTGAAGGTGATTGGCTATGATCCGGCGGATCCAGCCTCGCTATCCCCTGCCGAGCTACTACGTTGTGCTGATG
TGCTGGTGTTCTCTGTGCCGATCAGGAAAGCCGCTGCCTTGATTGGTGAATATGTGGCGATGGCTGATGGCACTGACGCT
GGGCAGCTTTGGATTGATGTGACCTCAATCAAGCAGGCCCCCGTGGAAGCAATGTTGGCTTCGCAAGCGGAGGTAGTTGG
CTTGCATCCTATGACTGCACCACCAAAGGCACCCACGCTAAAGGGCCGGGTGTTGGTGGTCTGCGAGGCGCGGCTACATC
ATTGGCGTCCGTGGTTGATGCAGTTGTGTGAGGCGTTGGAGGCCGAATGTGTGGCTGCGACGCCCGAGCACCATGACCGG
CTGATGGCGTTGGTACAGGCAATGGTACATGCCTGTCACTTGGCACAGGCGAGTGTGTTACGTGATTACCTGCCGCTATT
GGGCGAATTTCAGTCGATCATGTCATTTCGTTCGATGTCATTCGAGTTGGATATGGCGATGATTGCGCGGATTCTATCGT
TGAATCCGTCGATTTATGAGGATATCCAGTTTGGAAATTCGTATGTGCTTGAGATGCTAGACCATCTGCTTAGTCACTTG
CTGGAGCTGCGTGCATTGGTGAGTTGTGGTGATGATGCAGCACGTACTCGATTTCGTGCCGGCTTTTTGGAAGCCAACCA
CCAAGTTTTTCCAGAAGCGTCGTTAGTTGCAGGTAACTATAATTACGAGCGCATCGGTTATTTGTTGGCTGATTTGACCG
AACCGTTGGCTTTCAGCGTGTACCTTCCAGAGGATCGCCCTGGTTCATTGCAAAGGCTGCTGCACGTGTTCGAGCAGCAT
GGGATTAATTTGTCCTCGATCCATTCATCGCGTACGCCAGCAGGTGAACTGCATTTTCGGATTAGCTTTGACCCTGGGAG
CGATCGTGTTGCACTGATGCGAGCTGCCGATGAGATCGATATGCGCCGCATTGGTTGCGTGTTGACTCGGCCAGAACAGT
GA

Upstream 100 bases:

>100_bases
TAAAAAGCTTCTGGGACCGGATGACGTCTTAAGTGAATGAATGCCCGCGTTGCGTTTGGGCCATCATTGCTTTCGCCTGG
TGAGGTAAACGGATGTTGGT

Downstream 100 bases:

>100_bases
GCACTGTGTCTTGGAGGATGCTCGCCACAATGAAGACAGAGCTTTCATTCCGTGTTTACGATCACTCTCAAGATGCAACG
CGGCCTGCTCAATCAGGTGC

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MSASPVVGIVGSAGAYGHWLGRFLRERMDLKVIGYDPADPASLSPAELLRCADVLVFSVPIRKAAALIGEYVAMADGTDA
GQLWIDVTSIKQAPVEAMLASQAEVVGLHPMTAPPKAPTLKGRVLVVCEARLHHWRPWLMQLCEALEAECVAATPEHHDR
LMALVQAMVHACHLAQASVLRDYLPLLGEFQSIMSFRSMSFELDMAMIARILSLNPSIYEDIQFGNSYVLEMLDHLLSHL
LELRALVSCGDDAARTRFRAGFLEANHQVFPEASLVAGNYNYERIGYLLADLTEPLAFSVYLPEDRPGSLQRLLHVFEQH
GINLSSIHSSRTPAGELHFRISFDPGSDRVALMRAADEIDMRRIGCVLTRPEQ

Sequences:

>Translated_373_residues
MSASPVVGIVGSAGAYGHWLGRFLRERMDLKVIGYDPADPASLSPAELLRCADVLVFSVPIRKAAALIGEYVAMADGTDA
GQLWIDVTSIKQAPVEAMLASQAEVVGLHPMTAPPKAPTLKGRVLVVCEARLHHWRPWLMQLCEALEAECVAATPEHHDR
LMALVQAMVHACHLAQASVLRDYLPLLGEFQSIMSFRSMSFELDMAMIARILSLNPSIYEDIQFGNSYVLEMLDHLLSHL
LELRALVSCGDDAARTRFRAGFLEANHQVFPEASLVAGNYNYERIGYLLADLTEPLAFSVYLPEDRPGSLQRLLHVFEQH
GINLSSIHSSRTPAGELHFRISFDPGSDRVALMRAADEIDMRRIGCVLTRPEQ
>Mature_372_residues
SASPVVGIVGSAGAYGHWLGRFLRERMDLKVIGYDPADPASLSPAELLRCADVLVFSVPIRKAAALIGEYVAMADGTDAG
QLWIDVTSIKQAPVEAMLASQAEVVGLHPMTAPPKAPTLKGRVLVVCEARLHHWRPWLMQLCEALEAECVAATPEHHDRL
MALVQAMVHACHLAQASVLRDYLPLLGEFQSIMSFRSMSFELDMAMIARILSLNPSIYEDIQFGNSYVLEMLDHLLSHLL
ELRALVSCGDDAARTRFRAGFLEANHQVFPEASLVAGNYNYERIGYLLADLTEPLAFSVYLPEDRPGSLQRLLHVFEQHG
INLSSIHSSRTPAGELHFRISFDPGSDRVALMRAADEIDMRRIGCVLTRPEQ

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=274, Percent_Identity=25.9124087591241, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099 [H]

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH [H]

EC number: 1.3.1.12

Molecular weight: Translated: 41208; Mature: 41077

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASPVVGIVGSAGAYGHWLGRFLRERMDLKVIGYDPADPASLSPAELLRCADVLVFSVP
CCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
IRKAAALIGEYVAMADGTDAGQLWIDVTSIKQAPVEAMLASQAEVVGLHPMTAPPKAPTL
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
KGRVLVVCEARLHHWRPWLMQLCEALEAECVAATPEHHDRLMALVQAMVHACHLAQASVL
CCCEEEEEEHHHHCCCHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RDYLPLLGEFQSIMSFRSMSFELDMAMIARILSLNPSIYEDIQFGNSYVLEMLDHLLSHL
HHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHH
LELRALVSCGDDAARTRFRAGFLEANHQVFPEASLVAGNYNYERIGYLLADLTEPLAFSV
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
YLPEDRPGSLQRLLHVFEQHGINLSSIHSSRTPAGELHFRISFDPGSDRVALMRAADEID
ECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEEECCCCCCEEEHHHHHHHH
MRRIGCVLTRPEQ
HHHHCEEECCCCC
>Mature Secondary Structure 
SASPVVGIVGSAGAYGHWLGRFLRERMDLKVIGYDPADPASLSPAELLRCADVLVFSVP
CCCCCEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
IRKAAALIGEYVAMADGTDAGQLWIDVTSIKQAPVEAMLASQAEVVGLHPMTAPPKAPTL
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
KGRVLVVCEARLHHWRPWLMQLCEALEAECVAATPEHHDRLMALVQAMVHACHLAQASVL
CCCEEEEEEHHHHCCCHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RDYLPLLGEFQSIMSFRSMSFELDMAMIARILSLNPSIYEDIQFGNSYVLEMLDHLLSHL
HHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHH
LELRALVSCGDDAARTRFRAGFLEANHQVFPEASLVAGNYNYERIGYLLADLTEPLAFSV
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
YLPEDRPGSLQRLLHVFEQHGINLSSIHSSRTPAGELHFRISFDPGSDRVALMRAADEID
ECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEEECCCCCCEEEHHHHHHHH
MRRIGCVLTRPEQ
HHHHCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]