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The map label for this gene is dcp [H]

Identifier: 28198761

GI number: 28198761

Start: 1063943

End: 1066006

Strand: Reverse

Name: dcp [H]

Synonym: PD0856

Alternate gene names: 28198761

Gene position: 1066006-1063943 (Counterclockwise)

Preceding gene: 28198762

Following gene: 28198759

Centisome position: 42.31

GC content: 47.97

Gene sequence:

>2064_bases
ATGCCAGTTACTACCAGCAATCCACTGTTAACGGCCAGTTCCTTACCGTTCCAAGCGCCACCGTTCGATAAAATTAAGGA
CAGCGATTATTTGCCCGCGTTCGAGGAGGGAATGAAGCAACATCTGGCTGAAATCACCAAGATTGCTGAGAATCCCGATG
CACCGACCTTCGAAAACACTATCGAAATGCTGGAGCACAGCGGCACAACCTTGGATAGGGTCTCACGAATTTTTTTCGGT
CTAGTACATGCTGACACCAATGATACGCGCCAAAAGATTCAGGAAGAAATCGCGCCTAAGCTGGCTGCACACCAGGATGA
GATTTATTTGAATCCCAAGCTGTTCACTCGGATCAAGTCAATTTACGATCAGCGTGACACGCTTAGTTTGGACCCATTAC
AGAAACGTTTGGTCGAACGTGATTATGAAGGATTCGTACATGCCGGCGCTCAGTTGCCTGAAGCAGATAAAACAACTTTA
CGTAAAATCAACGTAGAAGAGAGTACTCTGTCCACACAGTTTCACGCTAAGCTAGTCGCCGCCACAGCGGCAAGTGCCAT
TGTGGTTGATGAAAAAAATAAACTTGATGGACTGAGCGAGGGCGACATTGCTGCAGCAGCGGAGGCTGCCAAGGCGCGTA
AGCTCAATGACAAGTACGTACTCGCATTACAAAATACCACTCAACAACCTATATCAGCTTCGCTGAAGGATCGTGAATTA
CGTGCTCTGGTGTTACAAGCTTCAGAAACTAGGGCCGAAAAAGGTGACGCTAACGATACCCGCCAAATCGTGCAGCGCCT
AACTCAGTTACGTGCACAAAAAGCCAAGTTACTCGGTTTCCCAAACTATGCCGCTTATAACTTGGCAGATCAGATGGCAA
AGACCCCTGAAGCAGCGCTAAAACTACTCAACGATACCGTGCCTGCGGCTACTGCAAAAGCACGTAAAGAGGCTGCCGAA
ATTCAAAAATTGATTGATAAGCAACGTGTCAATACTAAAGCGAATCACTTTGAGTTGGTTGCCTCTGACTGGGATTTCTA
TGCGGAGCAGGTGCGCAAAGCCAAGTACAATTTGGATGAAGAGCAAATCAAACCGTATTTTGAGCTCGACAACGTGCTGC
AAAACGGTGTTTTCTACGCCGCCAATCAGTTATACGGGATCACTTTTAAGGAGCGCAAAGATATACCAACTTACCATCCG
GACATGAAGGTTTACGAGGTGTTTGACCATGACGGCGGCTCGTTGGCACTGTTCTACACTGATTACTTTAAACGTGACAG
TAAATCCGGTGGTGCTTGGATGGATGTGTTCGTTGAACAAAATGCGATCACCGGGACCAAACCCGTGGTCTACAACGTTT
GCAACTTTACTAAGCCTGCACCTGGCCAGCCGGCACTATTGAGCTTCAAAGACGTGACCACCCTCTTCCACGAGTTTGGC
CATGCGTTACACGGGATGTTTTCGAAAGTGAAGTATCCTTCGTTGGCAGGCACCTCAACATCACGCGATTTTGTTGAATT
CCCGTCGCAATTCAACGAACACTGGGCCTCTGATCCAAAGGTGTTTTCACATTATGCCAAGCACTACCAAACCGGTGAGT
CCATGCCACAGAGTTTGGTGGACAGTATTCGCAAGGCAAAAACTTTCAACCAGGGTTACGCAACTACCGAGTACCTTTCA
GCCGCACTTCTAGACTTGGCTTGGCATACCTTGCCAGCCGATGCGCCACTGGAGGATGTGGACAAATTCGAAGCCGATGC
ACTGAAGAAGTACAAGGTCAATCTGAAAGAAGTGCCGCCACGCTATCGCACTAGCTATTTTGACCATATTTGGAGTGGCG
GCTATTCGGCAAGCTATTACGCTTACTTTTGGTCTGAAGTGTTGAGTGATGACGCATTCGAGTGGTTTAAGCAGCACGGT
GGTCTAGACCGTAAGAATGGCGATATATTCCGCGACAAAATTCTCTCGCGTGGCAACAGCATTGAGTTGGGCGATTTGTA
TCGGCAGTTCCGCGGCCAGAATCCGAGTGTGCAACCACTGTTAGATAACCGTGGGTTAAAATAA

Upstream 100 bases:

>100_bases
GCGTACCGCCATTTTGGCTGCTGCCATTAGTCTATCGCTTGCTGGTTGTTCTTCCAAAGAATCTTCCGCAATCCCTGAGA
AAACTACAACCACACCTCAA

Downstream 100 bases:

>100_bases
ATGAGCTAAGTGCTCGGCAGGACGAGATGGTATCCATCTCGTCCTGATTTCTAAATATGATCGGACAGCAAAATTTCTAA
CTTCAATTTAAGTAGAAATT

Product: peptidyl-dipeptidase

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MPVTTSNPLLTASSLPFQAPPFDKIKDSDYLPAFEEGMKQHLAEITKIAENPDAPTFENTIEMLEHSGTTLDRVSRIFFG
LVHADTNDTRQKIQEEIAPKLAAHQDEIYLNPKLFTRIKSIYDQRDTLSLDPLQKRLVERDYEGFVHAGAQLPEADKTTL
RKINVEESTLSTQFHAKLVAATAASAIVVDEKNKLDGLSEGDIAAAAEAAKARKLNDKYVLALQNTTQQPISASLKDREL
RALVLQASETRAEKGDANDTRQIVQRLTQLRAQKAKLLGFPNYAAYNLADQMAKTPEAALKLLNDTVPAATAKARKEAAE
IQKLIDKQRVNTKANHFELVASDWDFYAEQVRKAKYNLDEEQIKPYFELDNVLQNGVFYAANQLYGITFKERKDIPTYHP
DMKVYEVFDHDGGSLALFYTDYFKRDSKSGGAWMDVFVEQNAITGTKPVVYNVCNFTKPAPGQPALLSFKDVTTLFHEFG
HALHGMFSKVKYPSLAGTSTSRDFVEFPSQFNEHWASDPKVFSHYAKHYQTGESMPQSLVDSIRKAKTFNQGYATTEYLS
AALLDLAWHTLPADAPLEDVDKFEADALKKYKVNLKEVPPRYRTSYFDHIWSGGYSASYYAYFWSEVLSDDAFEWFKQHG
GLDRKNGDIFRDKILSRGNSIELGDLYRQFRGQNPSVQPLLDNRGLK

Sequences:

>Translated_687_residues
MPVTTSNPLLTASSLPFQAPPFDKIKDSDYLPAFEEGMKQHLAEITKIAENPDAPTFENTIEMLEHSGTTLDRVSRIFFG
LVHADTNDTRQKIQEEIAPKLAAHQDEIYLNPKLFTRIKSIYDQRDTLSLDPLQKRLVERDYEGFVHAGAQLPEADKTTL
RKINVEESTLSTQFHAKLVAATAASAIVVDEKNKLDGLSEGDIAAAAEAAKARKLNDKYVLALQNTTQQPISASLKDREL
RALVLQASETRAEKGDANDTRQIVQRLTQLRAQKAKLLGFPNYAAYNLADQMAKTPEAALKLLNDTVPAATAKARKEAAE
IQKLIDKQRVNTKANHFELVASDWDFYAEQVRKAKYNLDEEQIKPYFELDNVLQNGVFYAANQLYGITFKERKDIPTYHP
DMKVYEVFDHDGGSLALFYTDYFKRDSKSGGAWMDVFVEQNAITGTKPVVYNVCNFTKPAPGQPALLSFKDVTTLFHEFG
HALHGMFSKVKYPSLAGTSTSRDFVEFPSQFNEHWASDPKVFSHYAKHYQTGESMPQSLVDSIRKAKTFNQGYATTEYLS
AALLDLAWHTLPADAPLEDVDKFEADALKKYKVNLKEVPPRYRTSYFDHIWSGGYSASYYAYFWSEVLSDDAFEWFKQHG
GLDRKNGDIFRDKILSRGNSIELGDLYRQFRGQNPSVQPLLDNRGLK
>Mature_686_residues
PVTTSNPLLTASSLPFQAPPFDKIKDSDYLPAFEEGMKQHLAEITKIAENPDAPTFENTIEMLEHSGTTLDRVSRIFFGL
VHADTNDTRQKIQEEIAPKLAAHQDEIYLNPKLFTRIKSIYDQRDTLSLDPLQKRLVERDYEGFVHAGAQLPEADKTTLR
KINVEESTLSTQFHAKLVAATAASAIVVDEKNKLDGLSEGDIAAAAEAAKARKLNDKYVLALQNTTQQPISASLKDRELR
ALVLQASETRAEKGDANDTRQIVQRLTQLRAQKAKLLGFPNYAAYNLADQMAKTPEAALKLLNDTVPAATAKARKEAAEI
QKLIDKQRVNTKANHFELVASDWDFYAEQVRKAKYNLDEEQIKPYFELDNVLQNGVFYAANQLYGITFKERKDIPTYHPD
MKVYEVFDHDGGSLALFYTDYFKRDSKSGGAWMDVFVEQNAITGTKPVVYNVCNFTKPAPGQPALLSFKDVTTLFHEFGH
ALHGMFSKVKYPSLAGTSTSRDFVEFPSQFNEHWASDPKVFSHYAKHYQTGESMPQSLVDSIRKAKTFNQGYATTEYLSA
ALLDLAWHTLPADAPLEDVDKFEADALKKYKVNLKEVPPRYRTSYFDHIWSGGYSASYYAYFWSEVLSDDAFEWFKQHGG
LDRKNGDIFRDKILSRGNSIELGDLYRQFRGQNPSVQPLLDNRGLK

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=604, Percent_Identity=28.6423841059603, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI14149738, Length=620, Percent_Identity=25.8064516129032, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI156105687, Length=433, Percent_Identity=24.9422632794457, Blast_Score=140, Evalue=5e-33,
Organism=Escherichia coli, GI1787819, Length=684, Percent_Identity=54.093567251462, Blast_Score=767, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=696, Percent_Identity=32.6149425287356, Blast_Score=352, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI32565901, Length=465, Percent_Identity=24.9462365591398, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71999758, Length=658, Percent_Identity=21.7325227963526, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319793, Length=571, Percent_Identity=28.3712784588441, Blast_Score=200, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6322715, Length=437, Percent_Identity=26.7734553775744, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21356111, Length=456, Percent_Identity=25.6578947368421, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI20129717, Length=421, Percent_Identity=26.1282660332542, Blast_Score=132, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 77603; Mature: 77472

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTTSNPLLTASSLPFQAPPFDKIKDSDYLPAFEEGMKQHLAEITKIAENPDAPTFENT
CCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
IEMLEHSGTTLDRVSRIFFGLVHADTNDTRQKIQEEIAPKLAAHQDEIYLNPKLFTRIKS
HHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHH
IYDQRDTLSLDPLQKRLVERDYEGFVHAGAQLPEADKTTLRKINVEESTLSTQFHAKLVA
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHH
ATAASAIVVDEKNKLDGLSEGDIAAAAEAAKARKLNDKYVLALQNTTQQPISASLKDREL
HHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCHHHHHH
RALVLQASETRAEKGDANDTRQIVQRLTQLRAQKAKLLGFPNYAAYNLADQMAKTPEAAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
KLLNDTVPAATAKARKEAAEIQKLIDKQRVNTKANHFELVASDWDFYAEQVRKAKYNLDE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCH
EQIKPYFELDNVLQNGVFYAANQLYGITFKERKDIPTYHPDMKVYEVFDHDGGSLALFYT
HHCCHHHHHHHHHHCCHHEECCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
DYFKRDSKSGGAWMDVFVEQNAITGTKPVVYNVCNFTKPAPGQPALLSFKDVTTLFHEFG
HHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHH
HALHGMFSKVKYPSLAGTSTSRDFVEFPSQFNEHWASDPKVFSHYAKHYQTGESMPQSLV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHH
DSIRKAKTFNQGYATTEYLSAALLDLAWHTLPADAPLEDVDKFEADALKKYKVNLKEVPP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHCCC
RYRTSYFDHIWSGGYSASYYAYFWSEVLSDDAFEWFKQHGGLDRKNGDIFRDKILSRGNS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
IELGDLYRQFRGQNPSVQPLLDNRGLK
CCHHHHHHHHCCCCCCCCCHHCCCCCC
>Mature Secondary Structure 
PVTTSNPLLTASSLPFQAPPFDKIKDSDYLPAFEEGMKQHLAEITKIAENPDAPTFENT
CCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
IEMLEHSGTTLDRVSRIFFGLVHADTNDTRQKIQEEIAPKLAAHQDEIYLNPKLFTRIKS
HHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHH
IYDQRDTLSLDPLQKRLVERDYEGFVHAGAQLPEADKTTLRKINVEESTLSTQFHAKLVA
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHH
ATAASAIVVDEKNKLDGLSEGDIAAAAEAAKARKLNDKYVLALQNTTQQPISASLKDREL
HHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCHHHHHH
RALVLQASETRAEKGDANDTRQIVQRLTQLRAQKAKLLGFPNYAAYNLADQMAKTPEAAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
KLLNDTVPAATAKARKEAAEIQKLIDKQRVNTKANHFELVASDWDFYAEQVRKAKYNLDE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCH
EQIKPYFELDNVLQNGVFYAANQLYGITFKERKDIPTYHPDMKVYEVFDHDGGSLALFYT
HHCCHHHHHHHHHHCCHHEECCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
DYFKRDSKSGGAWMDVFVEQNAITGTKPVVYNVCNFTKPAPGQPALLSFKDVTTLFHEFG
HHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHH
HALHGMFSKVKYPSLAGTSTSRDFVEFPSQFNEHWASDPKVFSHYAKHYQTGESMPQSLV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHH
DSIRKAKTFNQGYATTEYLSAALLDLAWHTLPADAPLEDVDKFEADALKKYKVNLKEVPP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHCCC
RYRTSYFDHIWSGGYSASYYAYFWSEVLSDDAFEWFKQHGGLDRKNGDIFRDKILSRGNS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
IELGDLYRQFRGQNPSVQPLLDNRGLK
CCHHHHHHHHCCCCCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]