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The map label for this gene is folE [H]

Identifier: 28198728

GI number: 28198728

Start: 1014789

End: 1015409

Strand: Reverse

Name: folE [H]

Synonym: PD0823

Alternate gene names: 28198728

Gene position: 1015409-1014789 (Counterclockwise)

Preceding gene: 28198731

Following gene: 28198727

Centisome position: 40.3

GC content: 51.53

Gene sequence:

>621_bases
TTGCTCATCATGGACCATTCCAAACAACAAAACGCATCCATCACCCAAGCTCAGGCAGAAGAGGCCGTACGCACACTTCT
ACGTTGGGCCGGCGAAGATCCCACTCGTGAAGGCTTGCTCGACACACCACGCCGTGTCGTTGAAGCATACGGAGATTGGT
TCAGCGGTTACCGCGAAGATCCTCATGACTACCTGCAACGCACTTTCGAGGAAATCTCTTGCTACGACGAGATGATCGTA
CTACGTAACATTACCTATGAAAGCCACTGCGAACATCACATGGCACCCATCATCGGTAAAGTTCACGTTGGCTACTTGCC
AAACGGCAAAGTCGTCGGCATCAGCAAATTAGCACGCGTTGTTGAATCCTATGCGCGCCGCTTCCAGATACAGGAAAAAA
TGACTGCGCAAATTGCAGCATGTATCCAAGACACATTGACCCCACGTGGCGTCGGTGTCGTGATTGAAGGTGCACACGCA
TGTATGACTACCCGAGGTATACACAAGCGTGGTGTATCAATGGTCACCTCAAAGATGCTCGGCACCTTCCGCGAAGACGC
ACGCACCCGCGCCGAGTTCTTACAGTTCATCGAAGTAGGTACCAACGTGATCGACTTATGA

Upstream 100 bases:

>100_bases
ATCAGCACTTCTAAAATTCATTATCAGCCGTATTTAACATGTACCCCCCTTACCTTTCAAAGAGAGTGAGTTCAGGTACC
ATGCATGTTACACATACTGT

Downstream 100 bases:

>100_bases
ATGACTGCGGCCACATCGGCAGCTACCGTTCCCTTCGCTACCAAGCACTCTAGAAGCTGTGGTTTCTGCCGATCAGGTTC
CTAAAATCATCGGATTTTTT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MLIMDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYREDPHDYLQRTFEEISCYDEMIV
LRNITYESHCEHHMAPIIGKVHVGYLPNGKVVGISKLARVVESYARRFQIQEKMTAQIAACIQDTLTPRGVGVVIEGAHA
CMTTRGIHKRGVSMVTSKMLGTFREDARTRAEFLQFIEVGTNVIDL

Sequences:

>Translated_206_residues
MLIMDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYREDPHDYLQRTFEEISCYDEMIV
LRNITYESHCEHHMAPIIGKVHVGYLPNGKVVGISKLARVVESYARRFQIQEKMTAQIAACIQDTLTPRGVGVVIEGAHA
CMTTRGIHKRGVSMVTSKMLGTFREDARTRAEFLQFIEVGTNVIDL
>Mature_206_residues
MLIMDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYREDPHDYLQRTFEEISCYDEMIV
LRNITYESHCEHHMAPIIGKVHVGYLPNGKVVGISKLARVVESYARRFQIQEKMTAQIAACIQDTLTPRGVGVVIEGAHA
CMTTRGIHKRGVSMVTSKMLGTFREDARTRAEFLQFIEVGTNVIDL

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=177, Percent_Identity=50.2824858757062, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI4503949, Length=177, Percent_Identity=50.2824858757062, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI66932970, Length=147, Percent_Identity=46.2585034013605, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI66932972, Length=140, Percent_Identity=48.5714285714286, Blast_Score=137, Evalue=7e-33,
Organism=Escherichia coli, GI1788476, Length=175, Percent_Identity=36, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=177, Percent_Identity=46.3276836158192, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6321706, Length=178, Percent_Identity=51.123595505618, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24656782, Length=197, Percent_Identity=43.6548223350254, Blast_Score=156, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24656791, Length=197, Percent_Identity=43.6548223350254, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24656796, Length=197, Percent_Identity=43.6548223350254, Blast_Score=156, Evalue=1e-38,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 23341; Mature: 23341

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIMDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYRED
CEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PHDYLQRTFEEISCYDEMIVLRNITYESHCEHHMAPIIGKVHVGYLPNGKVVGISKLARV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCEECHHHHHHH
VESYARRFQIQEKMTAQIAACIQDTLTPRGVGVVIEGAHACMTTRGIHKRGVSMVTSKML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
GTFREDARTRAEFLQFIEVGTNVIDL
HHHHHHHHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure
MLIMDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYRED
CEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PHDYLQRTFEEISCYDEMIVLRNITYESHCEHHMAPIIGKVHVGYLPNGKVVGISKLARV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCEECHHHHHHH
VESYARRFQIQEKMTAQIAACIQDTLTPRGVGVVIEGAHACMTTRGIHKRGVSMVTSKML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
GTFREDARTRAEFLQFIEVGTNVIDL
HHHHHHHHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA