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The map label for this gene is recQ [H]

Identifier: 28198526

GI number: 28198526

Start: 756923

End: 758725

Strand: Reverse

Name: recQ [H]

Synonym: PD0617

Alternate gene names: 28198526

Gene position: 758725-756923 (Counterclockwise)

Preceding gene: 28198527

Following gene: 28198525

Centisome position: 30.11

GC content: 56.68

Gene sequence:

>1803_bases
ATGAGCACGTCTTCCGCCACCCAGACCGTTCTACAACGCGTCTTCGGCTACGACACCTTCCGTGGGCCCCAGCAAGCCAT
CATTGAGCATGTCGCTGCCGGCCACGATGCCTTGGTCCTGATGCCCACCGGGGGCGGCAAATCATTGTGCTACCAAGTGC
CTGCGCTGCTGCGCAAAGGCATCGGCGTCGTCATCTCGCCGCTGATTGCACTGATGCAAGACCAAGTCGAGACCCTACGT
CAGCTTGGCGTACGCGCCGCCTATCTCAACTCGACCCTAGATGCAACGCAGGCACAACGGATCGAACACGCTCTAGTCAC
CGCAGATCTAGACCTGCTGTATATCACTCCGGAACGGTTACTCACTGCACACTTCTTATCGCTGCTGGAACGTAGCCAGA
TCGCTTTGTTCGCAATAGACGAAGCTCACTGCGTCTCACAGTGGGGACATGATTTCCGTCCCGAATACCGCCAACTCACC
GTACTTCATGAACGTTGGCCACACGTGCCTCGGATTGCACTGACCGCAACCGCCGACCCACCCACGCAACGCGAAATTGC
TGAGCGCCTTGACCTAAGCGATGCGCATCACTTCATCAGCTCATTCGACCGCCCCAACATCCGCTACACGGTCGTGCAGA
AAAACAATATGCGGCGCCAACTACAAGAATTCCTCAGCCGCCATCGCAACACCGCAGGCATTGTCTACGCCATGTCACGG
CGCAAAACCGAAGAAATCGCCGCCTATCTGTGTACACAAGGCTACAACGCACTGCCTTACCATGCCGGCCTACCAGCCGA
AACACGGGCCAAGCACCAACGCTGCTTTCTGCGTGAAGAAGGGATTGTGATGTGTGCCACCATCGCCTTCGGCATGGGCA
TCAACAAACCTGATGTCCGCTTTGTCGCCCACATCGACCTCCCCAAATCACTGGAGGGTTATTACCAGGAAACCGGCCGC
GCCGGCCGCGATGGCGAAGCTGCAGAAGCATGGATGTGCTATAGCCTGGGAGACGTCGTACTGCTGAAACAAATGATCGA
ACAAAGCGAAGCCAGCGAAGCACGCAAGTGCGTAGAACGCGCCAAACTCGATCACCTGCTGGGCTACTGCGAATCAATGC
AATGCCGCCGCCAACTCTTACTGTCCAGCTTCGGGGAAACGTATCCAAACCCCTGTGGCAACTGTGACAACTGCCTGACC
CCAGCCACCGCCTGGGATGCCACCGTGCTCTCCCAAAAGGCGTTAAGTTGCGTCTACCGCACTGGCCAGCGCTTCGGGGT
TGGTCACCTCATCGACATACTACGTGGCAGTAAGAGCCAAAGAATATTGCAACTGGGTCATGACCAACTCAGCACCTACG
GCATCGGCCGTGACGTGGATGAACGCAGCTGGCGCAGTGTCTTTCGCCAACTCGTCGCCACACACCTGTTGGAGGTCGAC
AACGAAGGCTACGGCGGCTTACGCCTGACCCCAAGCAGTCGTCCAGTCCTCAAAGGCGAACGCCAAGTCATGATGCGTCG
TGATCAGTTCATCCGTGAACGCGACCGTACCGGCCAACGTCACGGACTATCGGTCCTCCCGGAAGATCTGGGACTCTTCA
ATGCCCTGCATCGCTTACGTGCACAACTCGCCAAAGAACAAAACGTGCCGGCATTCGTGATCTTCCATGACAGCACCTTG
CGCCATATTGCCGAGCAACGCCCTACCAACATCAATGCACTGAGCAAAATCAACGGGATCGGCAGCAACAAACTGACACG
CTATGGCCATCAGTTAATTGAACTCGTACTTGCGCAAGGATGA

Upstream 100 bases:

>100_bases
GGGAGTGTGCAGCACAACCGCACACTCTGCTGTGTTGAGCTTCCCGGCACCAGGGCAGTTCCGCAGAAATGCTATCTCCC
CCCAACCGGCAAGAAGCCTA

Downstream 100 bases:

>100_bases
ATCAATCCATGTATTCTCCGTGAAGGATGCAGAGCGCTGGCCGATGCCACTCCATGTTCCATAGCCAACATTGCTCAATG
ACTCGATAGGGATCGCCATC

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MSTSSATQTVLQRVFGYDTFRGPQQAIIEHVAAGHDALVLMPTGGGKSLCYQVPALLRKGIGVVISPLIALMQDQVETLR
QLGVRAAYLNSTLDATQAQRIEHALVTADLDLLYITPERLLTAHFLSLLERSQIALFAIDEAHCVSQWGHDFRPEYRQLT
VLHERWPHVPRIALTATADPPTQREIAERLDLSDAHHFISSFDRPNIRYTVVQKNNMRRQLQEFLSRHRNTAGIVYAMSR
RKTEEIAAYLCTQGYNALPYHAGLPAETRAKHQRCFLREEGIVMCATIAFGMGINKPDVRFVAHIDLPKSLEGYYQETGR
AGRDGEAAEAWMCYSLGDVVLLKQMIEQSEASEARKCVERAKLDHLLGYCESMQCRRQLLLSSFGETYPNPCGNCDNCLT
PATAWDATVLSQKALSCVYRTGQRFGVGHLIDILRGSKSQRILQLGHDQLSTYGIGRDVDERSWRSVFRQLVATHLLEVD
NEGYGGLRLTPSSRPVLKGERQVMMRRDQFIRERDRTGQRHGLSVLPEDLGLFNALHRLRAQLAKEQNVPAFVIFHDSTL
RHIAEQRPTNINALSKINGIGSNKLTRYGHQLIELVLAQG

Sequences:

>Translated_600_residues
MSTSSATQTVLQRVFGYDTFRGPQQAIIEHVAAGHDALVLMPTGGGKSLCYQVPALLRKGIGVVISPLIALMQDQVETLR
QLGVRAAYLNSTLDATQAQRIEHALVTADLDLLYITPERLLTAHFLSLLERSQIALFAIDEAHCVSQWGHDFRPEYRQLT
VLHERWPHVPRIALTATADPPTQREIAERLDLSDAHHFISSFDRPNIRYTVVQKNNMRRQLQEFLSRHRNTAGIVYAMSR
RKTEEIAAYLCTQGYNALPYHAGLPAETRAKHQRCFLREEGIVMCATIAFGMGINKPDVRFVAHIDLPKSLEGYYQETGR
AGRDGEAAEAWMCYSLGDVVLLKQMIEQSEASEARKCVERAKLDHLLGYCESMQCRRQLLLSSFGETYPNPCGNCDNCLT
PATAWDATVLSQKALSCVYRTGQRFGVGHLIDILRGSKSQRILQLGHDQLSTYGIGRDVDERSWRSVFRQLVATHLLEVD
NEGYGGLRLTPSSRPVLKGERQVMMRRDQFIRERDRTGQRHGLSVLPEDLGLFNALHRLRAQLAKEQNVPAFVIFHDSTL
RHIAEQRPTNINALSKINGIGSNKLTRYGHQLIELVLAQG
>Mature_599_residues
STSSATQTVLQRVFGYDTFRGPQQAIIEHVAAGHDALVLMPTGGGKSLCYQVPALLRKGIGVVISPLIALMQDQVETLRQ
LGVRAAYLNSTLDATQAQRIEHALVTADLDLLYITPERLLTAHFLSLLERSQIALFAIDEAHCVSQWGHDFRPEYRQLTV
LHERWPHVPRIALTATADPPTQREIAERLDLSDAHHFISSFDRPNIRYTVVQKNNMRRQLQEFLSRHRNTAGIVYAMSRR
KTEEIAAYLCTQGYNALPYHAGLPAETRAKHQRCFLREEGIVMCATIAFGMGINKPDVRFVAHIDLPKSLEGYYQETGRA
GRDGEAAEAWMCYSLGDVVLLKQMIEQSEASEARKCVERAKLDHLLGYCESMQCRRQLLLSSFGETYPNPCGNCDNCLTP
ATAWDATVLSQKALSCVYRTGQRFGVGHLIDILRGSKSQRILQLGHDQLSTYGIGRDVDERSWRSVFRQLVATHLLEVDN
EGYGGLRLTPSSRPVLKGERQVMMRRDQFIRERDRTGQRHGLSVLPEDLGLFNALHRLRAQLAKEQNVPAFVIFHDSTLR
HIAEQRPTNINALSKINGIGSNKLTRYGHQLIELVLAQG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=636, Percent_Identity=35.062893081761, Blast_Score=349, Evalue=6e-96,
Organism=Homo sapiens, GI14591902, Length=410, Percent_Identity=38.2926829268293, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI14591904, Length=410, Percent_Identity=38.2926829268293, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI148612816, Length=426, Percent_Identity=39.906103286385, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI169218196, Length=501, Percent_Identity=36.127744510978, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI110735439, Length=501, Percent_Identity=36.127744510978, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI51242943, Length=399, Percent_Identity=40.3508771929825, Blast_Score=272, Evalue=8e-73,
Organism=Homo sapiens, GI51242947, Length=399, Percent_Identity=40.3508771929825, Blast_Score=272, Evalue=8e-73,
Organism=Homo sapiens, GI284005309, Length=338, Percent_Identity=36.6863905325444, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI4758138, Length=340, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994977, Length=598, Percent_Identity=45.1505016722408, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI87082221, Length=336, Percent_Identity=24.1071428571429, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25145561, Length=642, Percent_Identity=34.2679127725857, Blast_Score=344, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI71987997, Length=413, Percent_Identity=39.4673123486683, Blast_Score=287, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI71987993, Length=413, Percent_Identity=39.4673123486683, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI32564293, Length=663, Percent_Identity=31.0708898944193, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17552866, Length=410, Percent_Identity=39.5121951219512, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI71995718, Length=366, Percent_Identity=21.5846994535519, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533224, Length=379, Percent_Identity=22.4274406332454, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=523, Percent_Identity=36.3288718929254, Blast_Score=346, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6321360, Length=342, Percent_Identity=23.6842105263158, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324217, Length=340, Percent_Identity=21.7647058823529, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324778, Length=362, Percent_Identity=23.2044198895028, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325138, Length=357, Percent_Identity=22.96918767507, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646066, Length=495, Percent_Identity=40.2020202020202, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24664226, Length=457, Percent_Identity=37.199124726477, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24664230, Length=457, Percent_Identity=36.980306345733, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI62472181, Length=457, Percent_Identity=36.980306345733, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI21358123, Length=359, Percent_Identity=38.1615598885794, Blast_Score=208, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28574962, Length=351, Percent_Identity=23.0769230769231, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 67540; Mature: 67409

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSATQTVLQRVFGYDTFRGPQQAIIEHVAAGHDALVLMPTGGGKSLCYQVPALLRKG
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCC
IGVVISPLIALMQDQVETLRQLGVRAAYLNSTLDATQAQRIEHALVTADLDLLYITPERL
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECHHHH
LTAHFLSLLERSQIALFAIDEAHCVSQWGHDFRPEYRQLTVLHERWPHVPRIALTATADP
HHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
PTQREIAERLDLSDAHHFISSFDRPNIRYTVVQKNNMRRQLQEFLSRHRNTAGIVYAMSR
CHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHH
RKTEEIAAYLCTQGYNALPYHAGLPAETRAKHQRCFLREEGIVMCATIAFGMGINKPDVR
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCE
FVAHIDLPKSLEGYYQETGRAGRDGEAAEAWMCYSLGDVVLLKQMIEQSEASEARKCVER
EEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKLDHLLGYCESMQCRRQLLLSSFGETYPNPCGNCDNCLTPATAWDATVLSQKALSCVYR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TGQRFGVGHLIDILRGSKSQRILQLGHDQLSTYGIGRDVDERSWRSVFRQLVATHLLEVD
CCCCCCHHHHHHHHHCCCHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHC
NEGYGGLRLTPSSRPVLKGERQVMMRRDQFIRERDRTGQRHGLSVLPEDLGLFNALHRLR
CCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AQLAKEQNVPAFVIFHDSTLRHIAEQRPTNINALSKINGIGSNKLTRYGHQLIELVLAQG
HHHHHHCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STSSATQTVLQRVFGYDTFRGPQQAIIEHVAAGHDALVLMPTGGGKSLCYQVPALLRKG
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCC
IGVVISPLIALMQDQVETLRQLGVRAAYLNSTLDATQAQRIEHALVTADLDLLYITPERL
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECHHHH
LTAHFLSLLERSQIALFAIDEAHCVSQWGHDFRPEYRQLTVLHERWPHVPRIALTATADP
HHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
PTQREIAERLDLSDAHHFISSFDRPNIRYTVVQKNNMRRQLQEFLSRHRNTAGIVYAMSR
CHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHH
RKTEEIAAYLCTQGYNALPYHAGLPAETRAKHQRCFLREEGIVMCATIAFGMGINKPDVR
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCE
FVAHIDLPKSLEGYYQETGRAGRDGEAAEAWMCYSLGDVVLLKQMIEQSEASEARKCVER
EEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKLDHLLGYCESMQCRRQLLLSSFGETYPNPCGNCDNCLTPATAWDATVLSQKALSCVYR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TGQRFGVGHLIDILRGSKSQRILQLGHDQLSTYGIGRDVDERSWRSVFRQLVATHLLEVD
CCCCCCHHHHHHHHHCCCHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHC
NEGYGGLRLTPSSRPVLKGERQVMMRRDQFIRERDRTGQRHGLSVLPEDLGLFNALHRLR
CCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AQLAKEQNVPAFVIFHDSTLRHIAEQRPTNINALSKINGIGSNKLTRYGHQLIELVLAQG
HHHHHHCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]