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The map label for this gene is zwf [H]

Identifier: 28198263

GI number: 28198263

Start: 436386

End: 437888

Strand: Reverse

Name: zwf [H]

Synonym: PD0346

Alternate gene names: 28198263

Gene position: 437888-436386 (Counterclockwise)

Preceding gene: 28198265

Following gene: 28198262

Centisome position: 17.38

GC content: 55.56

Gene sequence:

>1503_bases
ATGCTGCTCACGCAAACAAAAACACCCCCACACCAACAAACGTTAACATCCAAATCCGAGACCAGGTCCATGCACAACAC
CCTCTTATTGTTTGGCGCCACCGGCGACCTCGCCCAACGCTATCTCTTCCCCTCCTTACTGCAACTGTTTACTGATGGCT
TATTGCCACAAGACTTCCGCATTCGTGCTCTGGCCTTGTCACCCCATAACACCACACAATTCCGCGACATCCTGCGCACG
CGCTTGGAACAAGCACTACCCATCGCCAACACCGCGCACATCCAAGCCCTACTACAACGTGTCGACTACCTTTCCGTAGA
CTTGAACGACCCAACATCAATCGCCGAAGCAGTCCGAGATCTGACGGAACATCCCTGCATCAGCTACTTGGCAATCCCAC
CAGGCCTGTATACCAACACCGCCCTAGGATTGGCACAAGGAGGGGCACTGCAGACACCACACCGATTGATGCTGGAAAAA
CCGATCGGACGCGACTCAATAAACGCACGCGAAATCCTAAACACCATCGGCACACTGATTGACGAAGATCGCATCTTCCG
CGTAGACCACTATCTAGGCAAAGCAGCAGTGCAGAACCTCGTCGCACTGCGGTTCGGAAACACCCTGCTAGAAGCGGTAT
GGAACCGAAACCACATTGAGTCCGTACACATCCTCATCGCCGAAACCGAAGGCGTCGATGGCCGCAATGCTTACTACGCA
CGTGCTGGCGCACTACGTGACATGATGCAAAGCCACATCCTGCAACTCCTATGCCTGGTCGCTATGGAACCCCCGGTCTC
TATGGAAGCCGACCGCATACGCGACGAAAAAGTCAAAGTCCTGCGCGCACTACGCCCACTGAACGCCCAAAACGCCGCAA
TGCACAGCGTGCGCGGACGCTACAGCGCGGGCACCATTAACAGCCAACCAGTGCCAGCCTATCAACCACCAGAAGGCAGC
AATGTAGAGACCTTTGTCGGTGTCACCGCATACATCGACAACTGGCGCTGGGCGGGCGTACCGTTCCATCTATGCACAGG
AAAACGCTTGGCCGAACGCTCAACCCAAATCGTCGTCACCCTCAAACCCGTCACACACTGGCTATTTGAACGTCCAAACC
GGAACAATGCAGCACCAAACCGCCTGTGCTTCAAACTACAGCCCCAGGAAAATATCGAACTAAACCTGATGAGCAGCCTG
GCCGGCCCCGAATGGGGAACCCTAGAACTGCAACCGCTGGAATTGGAGTTATCCGTCCCAACCGGGAAACATCGCCACAT
CGCCTATGAGCGCCTTTTCCTCGACGCATTCAACGGCAACCCTGCGCTATTTGTACGTCACGACGAAGTCACAGAAGCCT
GGGCTTGGATCGACAGCATCAGCAATGCCTGGGAACTGTCCGACTTACCACTGCAACCCTACCCCGCCGGCGGCTGGGGC
CCACCTCAAGCCCACCAATTTCTGCCGCCATTGGGGATTGATGGCCATGGAAACAACGCATGA

Upstream 100 bases:

>100_bases
ACAAGCGGGTTCGCACTATCACCCGCTCCCATCCCTACTCCACCAACCCAGCACTAGCACATACACCACCAAACGCAACG
ATTAAGCCACGCATCAACAC

Downstream 100 bases:

>100_bases
ACGCACCACAGGCTCCCGTACTGGTCGCAGACATTGGAGGGACTAACGCCCGCTTTGCGCTCGCCAACCCCACCCTAACC
TCAGCACCACTGCTGAACGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLLTQTKTPPHQQTLTSKSETRSMHNTLLLFGATGDLAQRYLFPSLLQLFTDGLLPQDFRIRALALSPHNTTQFRDILRT
RLEQALPIANTAHIQALLQRVDYLSVDLNDPTSIAEAVRDLTEHPCISYLAIPPGLYTNTALGLAQGGALQTPHRLMLEK
PIGRDSINAREILNTIGTLIDEDRIFRVDHYLGKAAVQNLVALRFGNTLLEAVWNRNHIESVHILIAETEGVDGRNAYYA
RAGALRDMMQSHILQLLCLVAMEPPVSMEADRIRDEKVKVLRALRPLNAQNAAMHSVRGRYSAGTINSQPVPAYQPPEGS
NVETFVGVTAYIDNWRWAGVPFHLCTGKRLAERSTQIVVTLKPVTHWLFERPNRNNAAPNRLCFKLQPQENIELNLMSSL
AGPEWGTLELQPLELELSVPTGKHRHIAYERLFLDAFNGNPALFVRHDEVTEAWAWIDSISNAWELSDLPLQPYPAGGWG
PPQAHQFLPPLGIDGHGNNA

Sequences:

>Translated_500_residues
MLLTQTKTPPHQQTLTSKSETRSMHNTLLLFGATGDLAQRYLFPSLLQLFTDGLLPQDFRIRALALSPHNTTQFRDILRT
RLEQALPIANTAHIQALLQRVDYLSVDLNDPTSIAEAVRDLTEHPCISYLAIPPGLYTNTALGLAQGGALQTPHRLMLEK
PIGRDSINAREILNTIGTLIDEDRIFRVDHYLGKAAVQNLVALRFGNTLLEAVWNRNHIESVHILIAETEGVDGRNAYYA
RAGALRDMMQSHILQLLCLVAMEPPVSMEADRIRDEKVKVLRALRPLNAQNAAMHSVRGRYSAGTINSQPVPAYQPPEGS
NVETFVGVTAYIDNWRWAGVPFHLCTGKRLAERSTQIVVTLKPVTHWLFERPNRNNAAPNRLCFKLQPQENIELNLMSSL
AGPEWGTLELQPLELELSVPTGKHRHIAYERLFLDAFNGNPALFVRHDEVTEAWAWIDSISNAWELSDLPLQPYPAGGWG
PPQAHQFLPPLGIDGHGNNA
>Mature_500_residues
MLLTQTKTPPHQQTLTSKSETRSMHNTLLLFGATGDLAQRYLFPSLLQLFTDGLLPQDFRIRALALSPHNTTQFRDILRT
RLEQALPIANTAHIQALLQRVDYLSVDLNDPTSIAEAVRDLTEHPCISYLAIPPGLYTNTALGLAQGGALQTPHRLMLEK
PIGRDSINAREILNTIGTLIDEDRIFRVDHYLGKAAVQNLVALRFGNTLLEAVWNRNHIESVHILIAETEGVDGRNAYYA
RAGALRDMMQSHILQLLCLVAMEPPVSMEADRIRDEKVKVLRALRPLNAQNAAMHSVRGRYSAGTINSQPVPAYQPPEGS
NVETFVGVTAYIDNWRWAGVPFHLCTGKRLAERSTQIVVTLKPVTHWLFERPNRNNAAPNRLCFKLQPQENIELNLMSSL
AGPEWGTLELQPLELELSVPTGKHRHIAYERLFLDAFNGNPALFVRHDEVTEAWAWIDSISNAWELSDLPLQPYPAGGWG
PPQAHQFLPPLGIDGHGNNA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=32.9268292682927, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=32.9268292682927, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI52145310, Length=474, Percent_Identity=29.1139240506329, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1788158, Length=464, Percent_Identity=40.0862068965517, Blast_Score=353, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17538218, Length=503, Percent_Identity=32.4055666003976, Blast_Score=247, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324088, Length=503, Percent_Identity=32.0079522862823, Blast_Score=236, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24643352, Length=480, Percent_Identity=33.9583333333333, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24643350, Length=480, Percent_Identity=33.9583333333333, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI221513548, Length=478, Percent_Identity=28.0334728033473, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55865; Mature: 55865

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTQTKTPPHQQTLTSKSETRSMHNTLLLFGATGDLAQRYLFPSLLQLFTDGLLPQDFR
CCCCCCCCCCHHHHHCCHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCE
IRALALSPHNTTQFRDILRTRLEQALPIANTAHIQALLQRVDYLSVDLNDPTSIAEAVRD
EEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
LTEHPCISYLAIPPGLYTNTALGLAQGGALQTPHRLMLEKPIGRDSINAREILNTIGTLI
HHHCCCEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
DEDRIFRVDHYLGKAAVQNLVALRFGNTLLEAVWNRNHIESVHILIAETEGVDGRNAYYA
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHH
RAGALRDMMQSHILQLLCLVAMEPPVSMEADRIRDEKVKVLRALRPLNAQNAAMHSVRGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
YSAGTINSQPVPAYQPPEGSNVETFVGVTAYIDNWRWAGVPFHLCTGKRLAERSTQIVVT
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEE
LKPVTHWLFERPNRNNAAPNRLCFKLQPQENIELNLMSSLAGPEWGTLELQPLELELSVP
EEHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEHHHHCCCCCCEEEEEEEEEEEECC
TGKHRHIAYERLFLDAFNGNPALFVRHDEVTEAWAWIDSISNAWELSDLPLQPYPAGGWG
CCCCHHHEEEEHEEEEECCCCEEEEEECHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCC
PPQAHQFLPPLGIDGHGNNA
CCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLTQTKTPPHQQTLTSKSETRSMHNTLLLFGATGDLAQRYLFPSLLQLFTDGLLPQDFR
CCCCCCCCCCHHHHHCCHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCE
IRALALSPHNTTQFRDILRTRLEQALPIANTAHIQALLQRVDYLSVDLNDPTSIAEAVRD
EEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
LTEHPCISYLAIPPGLYTNTALGLAQGGALQTPHRLMLEKPIGRDSINAREILNTIGTLI
HHHCCCEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
DEDRIFRVDHYLGKAAVQNLVALRFGNTLLEAVWNRNHIESVHILIAETEGVDGRNAYYA
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHH
RAGALRDMMQSHILQLLCLVAMEPPVSMEADRIRDEKVKVLRALRPLNAQNAAMHSVRGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
YSAGTINSQPVPAYQPPEGSNVETFVGVTAYIDNWRWAGVPFHLCTGKRLAERSTQIVVT
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEE
LKPVTHWLFERPNRNNAAPNRLCFKLQPQENIELNLMSSLAGPEWGTLELQPLELELSVP
EEHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEHHHHCCCCCCEEEEEEEEEEEECC
TGKHRHIAYERLFLDAFNGNPALFVRHDEVTEAWAWIDSISNAWELSDLPLQPYPAGGWG
CCCCHHHEEEEHEEEEECCCCEEEEEECHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCC
PPQAHQFLPPLGIDGHGNNA
CCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]