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The map label for this gene is pyrH [H]

Identifier: 28198257

GI number: 28198257

Start: 429722

End: 430465

Strand: Reverse

Name: pyrH [H]

Synonym: PD0337

Alternate gene names: 28198257

Gene position: 430465-429722 (Counterclockwise)

Preceding gene: 28198258

Following gene: 28198253

Centisome position: 17.08

GC content: 51.88

Gene sequence:

>744_bases
TTGAGATATCCCATGTCAAAACTTGCCTATCACCGCGTTCTCCTCAAACTTTCAGGAGAGGCGTTGATGGGAAGTGCGGA
TTACGGCATTGATCCAAAAGTGATCAATCGACTGGCGGGTGAAGTCATTGAGGCACAAAACGCAGGTGCCGAGTTAGCCT
TGGTGATCGGCGGCGGTAACATCTTCCGAGGTGCAGGTCTGGCTGCCAAGGGTATGGACCGCGTCACCGGTGACCAGATG
GGGATGCTGGCAACAATCATCAACGCATTGGCAATGCAAGATGCACTGGAAAAGCTCGGCACCAAAGTACGAGTGATGAG
TGCAATCAAAATCAACAACGTATGCGAAGACTTCATCCGCCGCCGCGCAATCCGTCACCTGGAAAAAAGCCGTATCACCA
TCTTCGCAGCGGGCACTGGCAATCCCTTTTTCACCACCGATTCTGGCGCGGCGCTACGCGCCATTGAAATTGGCGCAGAT
TTGCTATTGAAGGCGACCAAAGTCGATGGCATTTACAACAAAGATCCGCAAAAGCACTGCGACGCAGTCAAGTACAGCAC
GCTGAGTTACGACGAAGTCATTTCGCAGAACCTTGAAGTCATGGATACCGCCGCCTTCGCACTGGCACGTGACAGCAACC
TACCATTACGCATTTTCGACATTGAGCAACCTGGCGTACTACTACGCATCTTGCACGGCGAAGAGATTGGCACTTTGGTC
AAGGAACGCAACTCAAAAAGCTAA

Upstream 100 bases:

>100_bases
AAATGATACTTCTCCACCAACATGACTTTGCTTTTGCTTTGCCAACAGCACAGCTTGTGCGCCTCCGCTAGAATGACACT
GTTTGCTCCCCCCTCACTCA

Downstream 100 bases:

>100_bases
AAATGATGGCCTGCCCATGTAAAAACGCTCGATCATCTCTGCATATCCACGGCTGTTGAGGCTGAAGGTCAAATAGAAGG
TAAGCAGGGCTCTGACCCGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MRYPMSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRGAGLAAKGMDRVTGDQM
GMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGAD
LLLKATKVDGIYNKDPQKHCDAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLV
KERNSKS

Sequences:

>Translated_247_residues
MRYPMSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRGAGLAAKGMDRVTGDQM
GMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGAD
LLLKATKVDGIYNKDPQKHCDAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLV
KERNSKS
>Mature_247_residues
MRYPMSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRGAGLAAKGMDRVTGDQM
GMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGAD
LLLKATKVDGIYNKDPQKHCDAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLV
KERNSKS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=54.0084388185654, Blast_Score=267, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26819; Mature: 26819

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYPMSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGN
CCCCHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
IFRGAGLAAKGMDRVTGDQMGMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIR
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHH
RRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGIYNKDPQKHC
HHHHHHHHHCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHEEHHHCCCCCCCCHHHHH
DAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLV
HHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCHHHHHH
KERNSKS
HHCCCCC
>Mature Secondary Structure
MRYPMSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGN
CCCCHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
IFRGAGLAAKGMDRVTGDQMGMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIR
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHH
RRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGIYNKDPQKHC
HHHHHHHHHCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHEEHHHCCCCCCCCHHHHH
DAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLV
HHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCHHHHHH
KERNSKS
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]