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The map label for this gene is cysK [C]

Identifier: 28198034

GI number: 28198034

Start: 125570

End: 126676

Strand: Reverse

Name: cysK [C]

Synonym: PD0098

Alternate gene names: 28198034

Gene position: 126676-125570 (Counterclockwise)

Preceding gene: 28198038

Following gene: 28198033

Centisome position: 5.03

GC content: 56.73

Gene sequence:

>1107_bases
ATGTCGCAGCGCGAGTGGGTCGCATCCTCCATCTGTAAGATCGAAGCTGATTTTAATCGCTCCGTTGACACCCATCTCAT
CCCGTTGCAGTTGCCTGGTTTCCCGGACATTGATTTCTATCTCAAAGACGAATCGATCCACCCCACTGGAAGCCTTAAGC
ATCGATTGGCACGTTCGTTGTTCTTGTACGCTCTGGTCAATGGTTGGCTGTCTCCAGGGCGGCCGGTGATTGAAGCATCC
AGCGGTTCAACGGCTGTCTCAGAGGCTTACTTCGCGAGGCTGTTGGGGCTTCCTTTTATCGCGGTGATCCCAACCTCGAC
CTCACCGGAGAAGGTGGCTGCGATCGAGTTTCACGGGGGGCGCTGTCACGCGGTCGAACGGGCGTGTGATCTGCATGATG
CTGCACATCAGTTGGCGCGTGAGACAGGGGGCCATTTCATGGACCAGTTCACTTACGCAGAACGTGCAACTGATTGGCGC
GCCAATAACAATATTGCTGAGTCGATCTTTAAGCAGATGGCCGATGAGCCACACCCAATTCCCGCCTGGATTGTGTGTAG
TCCGGGGACGGGAGGCACTGCTGCAACGCTCGGCCGCTATGTGCGCTACCGGCGTCACGTCACTCGCATCCTGTGCGCTG
ATCCGGAGATTTCGGTGTTCTTCGATCACTACCGCGCTGCCTGCAAGGGAAGCGATCATAGGAACAGCGTCACTGACACG
GGGGGATCTCGGATGGAAGGGATCGGCCGACCACGCTTAGAACCAAGTTTCATCCACAATTGTATCGACGCGATGATTAA
GGTGCCCGACGCGCTGAGTCTGGCGGCAATGCGCTATATCAGCGCTCGCTTAGGTCGACGTGTGGGCGGCTCCACTGGAA
CCAATATGGTGGGTGTGCTGCAAACCGCAGCACGCATGCGGGCTGAAGGCATGAAGGGTTCGATCGTCACCATTCTGTGT
GATGGAGGTGAACGTTACGCGCATAGTTACTATTCTCCAGCGTGGTACGCGGCACATGGCATTGATGTGTCGGACAGTGA
CGCGGTGATCGCTGCTGTCGTGGCAGGTGATACGTTGCCGCTGCTTCCTTGCGCGGCTCTGGAATGA

Upstream 100 bases:

>100_bases
TCATAAAAAAGCCGAACACGTCGCGAAACACTCAATGGGTGCTCAGAGGGTGCAAGGTGGCTATGGGAGAATCGACGCTT
TCTATCACTGTTGCTCTTTT

Downstream 100 bases:

>100_bases
CACCATAATCGGTAGGCATCTCCGCATTTGGCTGCATTCCCAAGACACAGAAGACACACATGAGTAACCCACTCCTCGAT
TTCTCAGACCTTCCTCGCTT

Product: cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSLFLYALVNGWLSPGRPVIEAS
SGSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETGGHFMDQFTYAERATDWR
ANNNIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDHYRAACKGSDHRNSVTDT
GGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVLQTAARMRAEGMKGSIVTILC
DGGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLPLLPCAALE

Sequences:

>Translated_368_residues
MSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSLFLYALVNGWLSPGRPVIEAS
SGSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETGGHFMDQFTYAERATDWR
ANNNIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDHYRAACKGSDHRNSVTDT
GGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVLQTAARMRAEGMKGSIVTILC
DGGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLPLLPCAALE
>Mature_367_residues
SQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSLFLYALVNGWLSPGRPVIEASS
GSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETGGHFMDQFTYAERATDWRA
NNNIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDHYRAACKGSDHRNSVTDTG
GSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVLQTAARMRAEGMKGSIVTILCD
GGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLPLLPCAALE

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=26.6025641025641, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71996324, Length=365, Percent_Identity=34.2465753424658, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17539800, Length=357, Percent_Identity=31.3725490196078, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17539640, Length=359, Percent_Identity=28.133704735376, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321449, Length=347, Percent_Identity=27.0893371757925, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=29.2604501607717, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=29.2604501607717, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 40059; Mature: 39928

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSL
CCCHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHH
FLYALVNGWLSPGRPVIEASSGSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGG
HHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCC
RCHAVERACDLHDAAHQLARETGGHFMDQFTYAERATDWRANNNIAESIFKQMADEPHPI
EEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
PAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDHYRAACKGSDHRNSVTDT
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCC
GGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVL
CCCHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
QTAARMRAEGMKGSIVTILCDGGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLP
HHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCCC
LLPCAALE
CCCCCCCC
>Mature Secondary Structure 
SQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSL
CCHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHH
FLYALVNGWLSPGRPVIEASSGSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGG
HHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCC
RCHAVERACDLHDAAHQLARETGGHFMDQFTYAERATDWRANNNIAESIFKQMADEPHPI
EEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
PAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDHYRAACKGSDHRNSVTDT
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCC
GGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVL
CCCHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
QTAARMRAEGMKGSIVTILCDGGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLP
HHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCCC
LLPCAALE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]