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The map label for this gene is uvrB [H]

Identifier: 27366360

GI number: 27366360

Start: 3159271

End: 3161301

Strand: Reverse

Name: uvrB [H]

Synonym: VV1_3092

Alternate gene names: 27366360

Gene position: 3161301-3159271 (Counterclockwise)

Preceding gene: 326424130

Following gene: 326424129

Centisome position: 96.33

GC content: 47.46

Gene sequence:

>2031_bases
ATGAGCAAACTTTACGATCTGGTTTCTGACTATGCGCCATCGGGAGATCAACCAACGGCGATCAAACAACTGACAGAAGG
GTTAGATGCTGGCTTGGCTCACCAAACCTTACTTGGGGTGACGGGATCCGGTAAAACATTTACTTTGGCTAATGTGATTG
CTCAAGCACAACGTCCTGCAATTCTGCTCGCGCCAAACAAAACTCTTGCCGCCCAACTTTACGGCGAGATGAAAGCGTTT
TTCCCCAATAACGCGGTCGAATATTTTGTCTCTTACTACGATTATTACCAACCTGAAGCCTATGTGCCAACCACCGACAC
CTTTATAGAGAAGGACTCATCGGTCAACGCTCATATTGAACAAATGCGTTTATCGGCCACCAAAGCGTTATTGGAGCGAA
AAGACGCTATTATCGTCGCCTCTGTTTCGGCTATTTATGGTTTGGGTGATCCCGAGGCCTACCTGCAAATGATGTTGCAT
ATACGCCGTGGTGATGTGATGGATCAACGCGACATACTGCGCCGTTTGGCTGAGCTGCAATATAGCCGTAACGATATTGC
TTTTGAACGAGGCCAATTTCGCGTGCGCGGAGAGGTGATCGACGTTTTTCCGGCTGAATCGGACCAAGATGCGGTGCGCA
TCGAGATGTTTGATGATGAGATCGACTGCATCAGTGTGTTTGATCCACTGACCGGAGTGGTCAAACAACGCGATTTACCC
CGCTTTACTATTTACCCTAAGACTCACTACGTCACACCTCGAGAGCGTATTCTGCAGGCGATTGAAAACATCAAACAAGA
GCTGCGTGAGCGACAAACTTACTTGCGTGACAACAATAAATTGTTGGAAGAGCAACGTATTAGTCAGCGTACCCAATTCG
ATATTGAAATGATGAATGAGCTGGGATTCTGCTCGGGCATCGAAAACTACTCGCGTTACCTCAGCGGTCGAGCGGAAGGT
GAGCCGCCTCCAACGTTATTTGACTACTTACCACACGACGGTTTGTTGATCATTGATGAATCTCACGTGACAGTGCCACA
AATTGGCGCAATGTATAAAGGTGACCGCTCACGGAAAGAGACCTTGGTTGAATATGGTTTCCGTTTGCCTTCAGCATTGG
ACAATCGACCATTGAAATTTGAAGAGTTCGAAGCGCTTGCGCCACAAACTATTTTCGTTTCAGCCACTCCGGGTAATTAC
GAACTAGAGAAAAGTGCGGGCGAAATTGCTGACCAAGTGGTGCGTCCGACCGGATTGCTCGATCCTGTACTGGAAGTGCG
ACCAGTGGCGACTCAAGTGGATGATCTGCTTTCTGAGATCCGCATTCGCGCGGTGAAAGATGAACGCGTGTTAGTGACAA
CACTGACCAAACGTATGGCGGAAGATCTAACTGAATACTTGCATGAGCACGATGTGAAAGTGCGTTACCTACACTCTGAT
ATCGACACGGTTGAACGAGTGGAGATCATTCGTGACTTGAGGCTAGGGGAGTTCGATGTGTTGGTGGGGATTAACTTGTT
ACGCGAGGGTCTCGACATGCCTGAAGTGTCTTTGGTTGCGATTCTCGATGCTGATAAAGAAGGCTTTTTACGTTCAGAGC
GCTCATTGATTCAGACCATTGGCCGTGCAGCCCGTAACCTCCATGGTAAAGCGATCTTGTATGCAGACTCCATCACCAAA
TCGATGAAGAAAGCGATGGATGAAACTGAACGACGCCGTGAGAAACAGCAAGCGTACAATGAAAAGATGGGCATTCAGCC
TCAAGCCTTGAAGCGTAATATCAAAGATATTATGGAGCTGGGCGATATTACGAAATCCCGCAAGCAGAAAGTGAGCAAAA
CGGTGCCATTGTCGAAAGTGGCTGAACCATCACTGTCCTATAATGTGTTGACGCCACAGCAACTGGAAAAAGAAATCACA
AAACTGGAAGCGCAAATGTACAAACACGCTCAGGATTTGGAATTTGAGTTAGCCGCGCAGAAGCGTGATGAAATTGAAAA
GTTGCGTCAGCAGTTTATTGCTAACAGCTAA

Upstream 100 bases:

>100_bases
GACTAAAAGGTGTGGTGTATGCCTAAATTGCAACTGTTCTTATGAAGGTTGGGAGTGTATATTTATACAGTTTTTACGTT
GTGCTGTAGTGAGAGGGAAA

Downstream 100 bases:

>100_bases
CCAAAGTGTGGTGAATTAGCGCTTGAAATGAACAAAAAAAAGCCAACAGTCATTTCACTATTGGCTATCAATTGTGAACA
CTAGGTTCACTAACAACGTC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPAILLAPNKTLAAQLYGEMKAF
FPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQMMLH
IRRGDVMDQRDILRRLAELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQRDLP
RFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSGRAEG
EPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSATPGNY
ELEKSAGEIADQVVRPTGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRYLHSD
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGKAILYADSITK
SMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLEKEIT
KLEAQMYKHAQDLEFELAAQKRDEIEKLRQQFIANS

Sequences:

>Translated_676_residues
MSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPAILLAPNKTLAAQLYGEMKAF
FPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQMMLH
IRRGDVMDQRDILRRLAELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQRDLP
RFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSGRAEG
EPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSATPGNY
ELEKSAGEIADQVVRPTGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRYLHSD
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGKAILYADSITK
SMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLEKEIT
KLEAQMYKHAQDLEFELAAQKRDEIEKLRQQFIANS
>Mature_675_residues
SKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPAILLAPNKTLAAQLYGEMKAFF
PNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQMMLHI
RRGDVMDQRDILRRLAELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQRDLPR
FTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSGRAEGE
PPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSATPGNYE
LEKSAGEIADQVVRPTGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRYLHSDI
DTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGKAILYADSITKS
MKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLEKEITK
LEAQMYKHAQDLEFELAAQKRDEIEKLRQQFIANS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=677, Percent_Identity=74.8892171344165, Blast_Score=1028, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=312, Percent_Identity=25.6410256410256, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77093; Mature: 76962

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPA
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHEEECCCCCEEHHHHHHHHCCCCE
ILLAPNKTLAAQLYGEMKAFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHH
QMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQMMLHIRRGDVMDQRDILRRLAELQ
HHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQRDLP
HCCCCCEEECCCEEEECEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
RFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNE
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRAEGEPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHH
TLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSATPGNYELEKSAGEIADQVVRPTGLL
HHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCC
DPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRYLHSD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLHGKAILYADSITKSMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMEL
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLEKEITKLEAQMYKHAQDLEFELAAQ
HHHHHHHHHHHHHCCCHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KRDEIEKLRQQFIANS
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPA
CHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHEEECCCCCEEHHHHHHHHCCCCE
ILLAPNKTLAAQLYGEMKAFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHH
QMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQMMLHIRRGDVMDQRDILRRLAELQ
HHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQRDLP
HCCCCCEEECCCEEEECEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
RFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNE
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRAEGEPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHH
TLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSATPGNYELEKSAGEIADQVVRPTGLL
HHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCC
DPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRYLHSD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLHGKAILYADSITKSMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMEL
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLEKEITKLEAQMYKHAQDLEFELAAQ
HHHHHHHHHHHHHCCCHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KRDEIEKLRQQFIANS
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]