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The map label for this gene is cobT

Identifier: 27366075

GI number: 27366075

Start: 2850686

End: 2851714

Strand: Reverse

Name: cobT

Synonym: VV1_2788

Alternate gene names: 27366075

Gene position: 2851714-2850686 (Counterclockwise)

Preceding gene: 27366082

Following gene: 27366074

Centisome position: 86.89

GC content: 53.06

Gene sequence:

>1029_bases
ATGTTAGAGCAACAATTTGCCGCTGAGATCCAGCACATCATCGACAACAAAACCAAACCGCTAGGCGCACTGGGGCAACT
CGAGCAAGTCGCCTTACAATTGGCACTCATCCAAAGCCAAGGTAAAGAGCAAGCGGCAACGCATATTGAGCTCAAGCAGC
CGCAGATGCTGCTTTTTGCCGGTGACCACGGTGTCGCGGATGAAGGGGTGAGCATCGCACCGAGTGCGGTGACACAACAA
ATGGTATTGAATTTTCTCGCAGGTGGCGCGGCGATAAACTGCTTTTGCGCGCTTCATAGCATCGACCTGACGGTGGTTGA
TTGTGGCATTTTGTTGCCTGTCGACAGTGACGCCCCGAATCTCATCTTACGTCGTTTGGGCTCACGCACCGCCAACTTTG
CGTTTGAGTCGGCCATGACGATTGAGCAAGTCGAACAAGCTTTGCGCAATGGTCAACAAATAGCGGCAGAGAAAATCGCT
CAAGGCGCAGATTTATTGATGTTTGGCGAGATGGGCATTGCCAACACCAGCTCTGCCGCGGCGCTGCTCAGTGCGTTATC
TGGCCACGAAGTGGATCACTGTGTCGGCAGAGGTACGGGCATTAATGAAGAGCAACTGTCGCACAAAATTAAAGTCGTGG
CGCAAGGCGTGGGGCGCTGTGAAGGTCTATCGGTTAATGCGATCCTCGCTGAAGTCGGCGGGTTTGAGATCGTGACCATG
GCTGGCGCGTTTATCGCTGCGGCTGAGCATAAAACCCCAGTGCTAGTGGACGGTTTTATTGTTTCGGTCGCGGCCTATAT
CGCGACGTTGCTGAAACCGGAGGTGAGAGACTACTTGTTGTTCGCTCATCGCTCCGAAGAACAAGGGCACCAAATTGTGT
TGTCACTCCTTGAAGCGAAGCCTTTGTTGGATTTGGGGCTGCGTCTTGGTGAAGGAACGGGAGCTGCACTGGCGTACCCA
CTATTAAAAGCGGCGGCGCAGTTTTACAACAATATGGCAAGCTTCGAAAGCGCAGGAGTAACGGTTTGA

Upstream 100 bases:

>100_bases
CCTCGATGAAGCGTATCTTGACTCTTTCTCCACGATCCCTTCGCCTGTACACTAGAGAACTTCTTGTTTTTACGCCATTT
CGACACCAACAGGGACAGTT

Downstream 100 bases:

>100_bases
TATGAAAACCTGGCAGTATCAGTACCAATTGTTTTGTTTGGCGGTGAGCTTTTTTAGCCGTTTGCCTGTGCCGAAATCAA
CACCGTATAGTGATGAAAGA

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLEQQFAAEIQHIIDNKTKPLGALGQLEQVALQLALIQSQGKEQAATHIELKQPQMLLFAGDHGVADEGVSIAPSAVTQQ
MVLNFLAGGAAINCFCALHSIDLTVVDCGILLPVDSDAPNLILRRLGSRTANFAFESAMTIEQVEQALRNGQQIAAEKIA
QGADLLMFGEMGIANTSSAAALLSALSGHEVDHCVGRGTGINEEQLSHKIKVVAQGVGRCEGLSVNAILAEVGGFEIVTM
AGAFIAAAEHKTPVLVDGFIVSVAAYIATLLKPEVRDYLLFAHRSEEQGHQIVLSLLEAKPLLDLGLRLGEGTGAALAYP
LLKAAAQFYNNMASFESAGVTV

Sequences:

>Translated_342_residues
MLEQQFAAEIQHIIDNKTKPLGALGQLEQVALQLALIQSQGKEQAATHIELKQPQMLLFAGDHGVADEGVSIAPSAVTQQ
MVLNFLAGGAAINCFCALHSIDLTVVDCGILLPVDSDAPNLILRRLGSRTANFAFESAMTIEQVEQALRNGQQIAAEKIA
QGADLLMFGEMGIANTSSAAALLSALSGHEVDHCVGRGTGINEEQLSHKIKVVAQGVGRCEGLSVNAILAEVGGFEIVTM
AGAFIAAAEHKTPVLVDGFIVSVAAYIATLLKPEVRDYLLFAHRSEEQGHQIVLSLLEAKPLLDLGLRLGEGTGAALAYP
LLKAAAQFYNNMASFESAGVTV
>Mature_342_residues
MLEQQFAAEIQHIIDNKTKPLGALGQLEQVALQLALIQSQGKEQAATHIELKQPQMLLFAGDHGVADEGVSIAPSAVTQQ
MVLNFLAGGAAINCFCALHSIDLTVVDCGILLPVDSDAPNLILRRLGSRTANFAFESAMTIEQVEQALRNGQQIAAEKIA
QGADLLMFGEMGIANTSSAAALLSALSGHEVDHCVGRGTGINEEQLSHKIKVVAQGVGRCEGLSVNAILAEVGGFEIVTM
AGAFIAAAEHKTPVLVDGFIVSVAAYIATLLKPEVRDYLLFAHRSEEQGHQIVLSLLEAKPLLDLGLRLGEGTGAALAYP
LLKAAAQFYNNMASFESAGVTV

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=337, Percent_Identity=35.3115727002967, Blast_Score=184, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_VIBVU (Q8D921)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_761603.1
- ProteinModelPortal:   Q8D921
- SMR:   Q8D921
- GeneID:   1179633
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_2788
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- BioCyc:   VVUL216895:VV1_2788-MONOMER
- BRENDA:   2.4.2.21
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 36044; Mature: 36044

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: ACT_SITE 311-311

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQQFAAEIQHIIDNKTKPLGALGQLEQVALQLALIQSQGKEQAATHIELKQPQMLLFA
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHEEEECCCEEEEEE
GDHGVADEGVSIAPSAVTQQMVLNFLAGGAAINCFCALHSIDLTVVDCGILLPVDSDAPN
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECEEEEECCCCCHH
LILRRLGSRTANFAFESAMTIEQVEQALRNGQQIAAEKIAQGADLLMFGEMGIANTSSAA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCHHHH
ALLSALSGHEVDHCVGRGTGINEEQLSHKIKVVAQGVGRCEGLSVNAILAEVGGFEIVTM
HHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEEH
AGAFIAAAEHKTPVLVDGFIVSVAAYIATLLKPEVRDYLLFAHRSEEQGHQIVLSLLEAK
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PLLDLGLRLGEGTGAALAYPLLKAAAQFYNNMASFESAGVTV
CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLEQQFAAEIQHIIDNKTKPLGALGQLEQVALQLALIQSQGKEQAATHIELKQPQMLLFA
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHEEEECCCEEEEEE
GDHGVADEGVSIAPSAVTQQMVLNFLAGGAAINCFCALHSIDLTVVDCGILLPVDSDAPN
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECEEEEECCCCCHH
LILRRLGSRTANFAFESAMTIEQVEQALRNGQQIAAEKIAQGADLLMFGEMGIANTSSAA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCHHHH
ALLSALSGHEVDHCVGRGTGINEEQLSHKIKVVAQGVGRCEGLSVNAILAEVGGFEIVTM
HHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEEH
AGAFIAAAEHKTPVLVDGFIVSVAAYIATLLKPEVRDYLLFAHRSEEQGHQIVLSLLEAK
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PLLDLGLRLGEGTGAALAYPLLKAAAQFYNNMASFESAGVTV
CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA