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The map label for this gene is yrhP [H]

Identifier: 27365988

GI number: 27365988

Start: 2746158

End: 2746793

Strand: Reverse

Name: yrhP [H]

Synonym: VV1_2697

Alternate gene names: 27365988

Gene position: 2746793-2746158 (Counterclockwise)

Preceding gene: 27365991

Following gene: 27365987

Centisome position: 83.7

GC content: 46.38

Gene sequence:

>636_bases
ATGGACATTTTAAATTTTGAAGCCTTTTTAATCGCCATTACCATCTTAACGTTAACTCCGGGGCTAGATACGGCATTGGT
CATTCGCAATACGACTCGTGCTGGCTTGCAAGATGGCTGCATGACGAGTTTAGGCATTTGCTGCGGTTTGTTTGTGCACG
CGCTGTTTTCTGCCATTGGGATTTCAGCCATTTTGGCGCAGTCAGCGGAGCTGTTTCAATTTGTAAAAATGATCGGGGCG
GCTTACCTTATTTGGCTGGGCTTTAGTAGCTTGAAGTCTTTGATGACAAGTGGTGCAGGGTTAAGCGTCGCGCAGATGGC
ACAGCAAAGTTACGACGCAAAACGCTCGTTGCGAGAAGGTTTTTTGTCGAATGTGCTCAATCCTAAAACGGCGGTCTTCT
ATTTGGCGTTTTTGCCACAGTTTGTTAATCCAGAGGGTTCACCTCTCTTACAATCAATGACGATGGCGGGAATTCATTTC
GTCATAGCGATGGTGTGGCAATGTGGGTTGGCTGGTGCGTTGAACTCAGCGAAAAATCTTTTGAAAAATGCGCAGTTCAT
GAAATGGATGGAAGGCGCAACAGGGGCCGTTTTGGTGGCTCTTGGTATTAAACTTTTGGTTGAAAAGCCAGTCTGA

Upstream 100 bases:

>100_bases
TTATACAACACTCTGGCAACGCCGTGTTCCTTGATTTGCTTGCGTAACGAATCAATAAAGAGTATTGATCTTCACACTTC
CAACATAATTCAGACAATAT

Downstream 100 bases:

>100_bases
TGCGTTTACTCACCAGTGTTTCTTTGGTATCGGTGATCTTTCTAAGTGGCTTTGCTGCCTTTGTCGCTTTGAAAACTGTG
CCTCAGTTAAATTTTGCGTC

Product: putative threonine efflux protein

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MDILNFEAFLIAITILTLTPGLDTALVIRNTTRAGLQDGCMTSLGICCGLFVHALFSAIGISAILAQSAELFQFVKMIGA
AYLIWLGFSSLKSLMTSGAGLSVAQMAQQSYDAKRSLREGFLSNVLNPKTAVFYLAFLPQFVNPEGSPLLQSMTMAGIHF
VIAMVWQCGLAGALNSAKNLLKNAQFMKWMEGATGAVLVALGIKLLVEKPV

Sequences:

>Translated_211_residues
MDILNFEAFLIAITILTLTPGLDTALVIRNTTRAGLQDGCMTSLGICCGLFVHALFSAIGISAILAQSAELFQFVKMIGA
AYLIWLGFSSLKSLMTSGAGLSVAQMAQQSYDAKRSLREGFLSNVLNPKTAVFYLAFLPQFVNPEGSPLLQSMTMAGIHF
VIAMVWQCGLAGALNSAKNLLKNAQFMKWMEGATGAVLVALGIKLLVEKPV
>Mature_211_residues
MDILNFEAFLIAITILTLTPGLDTALVIRNTTRAGLQDGCMTSLGICCGLFVHALFSAIGISAILAQSAELFQFVKMIGA
AYLIWLGFSSLKSLMTSGAGLSVAQMAQQSYDAKRSLREGFLSNVLNPKTAVFYLAFLPQFVNPEGSPLLQSMTMAGIHF
VIAMVWQCGLAGALNSAKNLLKNAQFMKWMEGATGAVLVALGIKLLVEKPV

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=196, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786522, Length=213, Percent_Identity=22.5352112676056, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788099, Length=141, Percent_Identity=26.241134751773, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994978, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22556; Mature: 22556

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILNFEAFLIAITILTLTPGLDTALVIRNTTRAGLQDGCMTSLGICCGLFVHALFSAIG
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
ISAILAQSAELFQFVKMIGAAYLIWLGFSSLKSLMTSGAGLSVAQMAQQSYDAKRSLREG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
FLSNVLNPKTAVFYLAFLPQFVNPEGSPLLQSMTMAGIHFVIAMVWQCGLAGALNSAKNL
HHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNAQFMKWMEGATGAVLVALGIKLLVEKPV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDILNFEAFLIAITILTLTPGLDTALVIRNTTRAGLQDGCMTSLGICCGLFVHALFSAIG
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
ISAILAQSAELFQFVKMIGAAYLIWLGFSSLKSLMTSGAGLSVAQMAQQSYDAKRSLREG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
FLSNVLNPKTAVFYLAFLPQFVNPEGSPLLQSMTMAGIHFVIAMVWQCGLAGALNSAKNL
HHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNAQFMKWMEGATGAVLVALGIKLLVEKPV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]