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The map label for this gene is zwf [H]

Identifier: 27365976

GI number: 27365976

Start: 2731173

End: 2732678

Strand: Reverse

Name: zwf [H]

Synonym: VV1_2684

Alternate gene names: 27365976

Gene position: 2732678-2731173 (Counterclockwise)

Preceding gene: 27365977

Following gene: 27365975

Centisome position: 83.27

GC content: 46.95

Gene sequence:

>1506_bases
ATGATGGTAATACCAGAAAACAGCAGCATCGTAATTTTTGGTGCTTCAGGTGATTTAACATATCGCAAGTTGATCCCTGC
TTTATACCACCTCTACGCAAGTAAGCAGCTACCAGAAAACTTTGCTATTTTAGGTGTCAGCCGCACTGAATACAGCGATG
AATCTTATCGCGAAAAGTTAAAGCGCTCTCTTCAGGAAATGGAGAAAACGGAACCAGCTATTCTGGATTCATTTATCGAC
CATCTTCACTATCAAGCCATCAACACGTCAGACACAAAAGACTACGCGAAGTTGGTTGTACGTTTAGATGAATTGGCCGC
TCAATACCAGTTCGAACAACGTAATACACTGTTTTATCTGGCCACACCGCCAAGCCTTTACAGTGTTATTCCTGCAAGCC
TTGCTCATCACGGTCTCAATAGTGAAGAGGATGGTTGGAAGCGCCTGATCATTGAAAAACCGTTTGGTTATGATTTGGCT
TCGGCACGTCAGCTCGACAAAGAAATACACGATTGCTTCCAAGAGCATCAGATCTATCGCATCGACCACTACCTTGGAAA
AGAGACCGTACAAAACTTACTTGTTTTCCGTTTCTCTAACGCCATGTTTGAACCTCTGTGGAACCGCAACTTCATTGATT
ATGTGGAAATCACAGGTGCCGAATTCCTTGGTGTGGAAGAGCGCGGTGGTTATTACGACGGCTCCGGCGCTGTGCGCGAT
ATGTTCCAAAACCACCTACTGCAAGTGTTGGCGATGGTGGGCATGGAGCCGCCAGCACAAATTAACGCCGATTCCATGCG
TGATGAAGTAGTGAAAGTTCTGCAGTGTTTAAAACCGCTTGAGGAAGATGATCTGCGTAACAACCTAGTTTTGGGTCAAT
ACACCGCATCAGACGTGCGCGGACAACATCTGCTTGGCTACCGTGAAGAAAACGGCGTAGCGGACGATTCTCGTACCGAG
ACTTACATTGGTCTTAAAGCGTACATCAATAACTGGCGTTGGAATGGCGTACCATTCTACGTGCGCACGGGTAAGCGTCT
TCCAACTCGCGTGACAGAAGTGGTTATCCACTTCAAACAAACACCGCATCCGGTATTTGGCCAAAACGCTCCAGAAAACA
AACTGATCATTCGTATTCAGCCTGATGAAGGCATTCAAATGAGCTTCGGTTTGAAAGAACCCGGTGCAGGCTTTAAAGCC
AAAGAAGTGAAGATGAACTTCCATTATGCTTCGTTGCAAGAGACGCAAATGCTGACCGCCTATGAGCGTCTGCTTCTTGA
TGCGTTAAACGGCGACGCAACGCTGTTTGCTCGCAGCGATGCGGTCGAAGCGTGTTGGAAATACGTTCAACCTATCCTCG
ATTTCAAACAAGATCCACAAGCACTCTTTGGTTATGCTTGCGGTACTTGGGGGCCAAAAGAGTCGGACGATTTGCTGCAG
CGTGATGATCGCGCGTGGCGTTTCCCATGCAAAAACCTAACAGATACGGACTACTGCGAACTATGA

Upstream 100 bases:

>100_bases
GGCAGGGCCGATTATCAATTTTTAGGTGTCACTGATAGGGTGGGCTCATCCTTTAAGCCGTATCCAGGCACACAACAAGT
ACCTCGTTTTTAAGGGAAAG

Downstream 100 bases:

>100_bases
TCAATCACAAGATCTACCAAACAGCAGAGCAGGTAGTAGAAAGCCTAGCAAACGACATGAAAGCGTTTAGCGAAATGGGC
CGACCTGTTCATATCTCACT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDESYREKLKRSLQEMEKTEPAILDSFID
HLHYQAINTSDTKDYAKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPASLAHHGLNSEEDGWKRLIIEKPFGYDLA
SARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYVEITGAEFLGVEERGGYYDGSGAVRD
MFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYTASDVRGQHLLGYREENGVADDSRTE
TYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKLIIRIQPDEGIQMSFGLKEPGAGFKA
KEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDFKQDPQALFGYACGTWGPKESDDLLQ
RDDRAWRFPCKNLTDTDYCEL

Sequences:

>Translated_501_residues
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDESYREKLKRSLQEMEKTEPAILDSFID
HLHYQAINTSDTKDYAKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPASLAHHGLNSEEDGWKRLIIEKPFGYDLA
SARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYVEITGAEFLGVEERGGYYDGSGAVRD
MFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYTASDVRGQHLLGYREENGVADDSRTE
TYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKLIIRIQPDEGIQMSFGLKEPGAGFKA
KEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDFKQDPQALFGYACGTWGPKESDDLLQ
RDDRAWRFPCKNLTDTDYCEL
>Mature_501_residues
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDESYREKLKRSLQEMEKTEPAILDSFID
HLHYQAINTSDTKDYAKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPASLAHHGLNSEEDGWKRLIIEKPFGYDLA
SARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYVEITGAEFLGVEERGGYYDGSGAVRD
MFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYTASDVRGQHLLGYREENGVADDSRTE
TYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKLIIRIQPDEGIQMSFGLKEPGAGFKA
KEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDFKQDPQALFGYACGTWGPKESDDLLQ
RDDRAWRFPCKNLTDTDYCEL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=474, Percent_Identity=39.0295358649789, Blast_Score=334, Evalue=9e-92,
Organism=Homo sapiens, GI108773793, Length=474, Percent_Identity=39.0295358649789, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI52145310, Length=363, Percent_Identity=31.6804407713499, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=41.7695473251029, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17538218, Length=476, Percent_Identity=37.8151260504202, Blast_Score=338, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=36.7768595041322, Blast_Score=302, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=37.888198757764, Blast_Score=301, Evalue=9e-82,
Organism=Drosophila melanogaster, GI24643352, Length=476, Percent_Identity=37.8151260504202, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI221513548, Length=475, Percent_Identity=31.1578947368421, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57567; Mature: 57567

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDESYREKL
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
KRSLQEMEKTEPAILDSFIDHLHYQAINTSDTKDYAKLVVRLDELAAQYQFEQRNTLFYL
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ATPPSLYSVIPASLAHHGLNSEEDGWKRLIIEKPFGYDLASARQLDKEIHDCFQEHQIYR
ECCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEE
IDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYVEITGAEFLGVEERGGYYDGSGAVRD
HHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCEECCCHHHHH
MFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYTASDVR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCEEEEECCHHHCC
GQHLLGYREENGVADDSRTETYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQ
CCHHCCCCCCCCCCCCCCCHHEEEHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCC
TPHPVFGQNAPENKLIIRIQPDEGIQMSFGLKEPGAGFKAKEVKMNFHYASLQETQMLTA
CCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEEEEEEEHHHHHHHHHHH
YERLLLDALNGDATLFARSDAVEACWKYVQPILDFKQDPQALFGYACGTWGPKESDDLLQ
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHH
RDDRAWRFPCKNLTDTDYCEL
CCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDESYREKL
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
KRSLQEMEKTEPAILDSFIDHLHYQAINTSDTKDYAKLVVRLDELAAQYQFEQRNTLFYL
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ATPPSLYSVIPASLAHHGLNSEEDGWKRLIIEKPFGYDLASARQLDKEIHDCFQEHQIYR
ECCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEE
IDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYVEITGAEFLGVEERGGYYDGSGAVRD
HHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCEECCCHHHHH
MFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYTASDVR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCEEEEECCHHHCC
GQHLLGYREENGVADDSRTETYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQ
CCHHCCCCCCCCCCCCCCCHHEEEHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCC
TPHPVFGQNAPENKLIIRIQPDEGIQMSFGLKEPGAGFKAKEVKMNFHYASLQETQMLTA
CCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEEEEEEEHHHHHHHHHHH
YERLLLDALNGDATLFARSDAVEACWKYVQPILDFKQDPQALFGYACGTWGPKESDDLLQ
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHH
RDDRAWRFPCKNLTDTDYCEL
CCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]