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The map label for this gene is pyrD [H]

Identifier: 27365930

GI number: 27365930

Start: 2674036

End: 2675046

Strand: Reverse

Name: pyrD [H]

Synonym: VV1_2637

Alternate gene names: 27365930

Gene position: 2675046-2674036 (Counterclockwise)

Preceding gene: 326424051

Following gene: 27365929

Centisome position: 81.51

GC content: 44.11

Gene sequence:

>1011_bases
ATGCTTTACCGTCTTGCCAGAGCTGGCTTTTTTCAATTGGATGCAGAAAAGGCACACGATCTCGCTATCCAAAACTTCAA
ACGCTTTACCGGCACACCAATTGATCTTTTCTATCGTCAACAACTCCCAAATCGACCAGTAGAATGCATGGGACTCACTT
TCCGAAACCCAGTTGGTCTTGCGGCTGGTCTGGATAAAAATGGTGAGTGTATAGAAGCATTTGACGCAATGGGATTCGGC
TTTGTTGAAGTTGGTACCGTTACACCTAGAGCACAATCAGGAAATGATAAACCACGTTTGTTCCGCTTAGTAGGGGCGGA
AGGGATCATTAACCGTATGGGTTTCAATAACCTAGGTGTTGACAATCTCATTGAAAACGTCAAGAAGGCCAAATACAGCT
GTGTATTAGGCATCAATATTGGTAAAAACAAAGACACACCAATCGAGAAGGGCGCGGAAGATTATCTCATCTGTATGGAA
AAGGTATATGAGTATGCGGGATATATTGCCGTGAATATTTCTTCTCCAAACACGCCTGGGCTAAGAACACTTCAATATGG
CGAAGCGCTTGATGAATTACTGGTTGAGTTAAAACGTAAGCAAGCTGAGCTTGAAGAGAAGCATGGAAAATATGTACCTC
TGGCATTAAAGATCGCACCGGATCTTACCGACGATGAGATTAGCCAGATTTGCCAATCGTTGATCAACAACAAGATCGAT
GGTGTGATCGCAACCAATACCACGCTTGATCGTACGATGGTTGAAGGCATGAAACATGCGCAAGAGGCTGGGGGCCTTAG
TGGTCGTCCACTGCAGTCTCGTTCTACTGAGGTCGTGCGATTACTTCGTAAAGAGTTACAAGGTAACATACCAATTATTG
GCGTCGGTGGTGTTGATTCTTATGTTGCTGCAAAAGAAAAAATGTTGGCAGGGGCGGATCTTGTACAAGTTTACTCTGGC
TTCATCTATCACGGCCCTGGCTTAGTACGCGATATTGTTAAAAATCTATAG

Upstream 100 bases:

>100_bases
TTTGGAATGCAATATCTTTGACGTTTTTGTTTGAAAAGTTGTTCTTTTAAGTAAATAATACCAACCCGTTTACACGGGGC
TTTTTTCTTTCGGAGGCACA

Downstream 100 bases:

>100_bases
AATGATTCGCTAACATACTGACATAGCAGCTTTTCTAACAGAAAAAAGAGGACTTGGTTTCCTCTTTTTTTTTATTCATT
CGTTTGTAGAATCAAAACAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGLAAGLDKNGECIEAFDAMGFG
FVEVGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICME
KVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
GVIATNTTLDRTMVEGMKHAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDSYVAAKEKMLAGADLVQVYSG
FIYHGPGLVRDIVKNL

Sequences:

>Translated_336_residues
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGLAAGLDKNGECIEAFDAMGFG
FVEVGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICME
KVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
GVIATNTTLDRTMVEGMKHAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDSYVAAKEKMLAGADLVQVYSG
FIYHGPGLVRDIVKNL
>Mature_336_residues
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGLAAGLDKNGECIEAFDAMGFG
FVEVGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICME
KVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
GVIATNTTLDRTMVEGMKHAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDSYVAAKEKMLAGADLVQVYSG
FIYHGPGLVRDIVKNL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=338, Percent_Identity=42.603550295858, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=66.9642857142857, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17509475, Length=333, Percent_Identity=42.042042042042, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI281361352, Length=328, Percent_Identity=42.9878048780488, Blast_Score=247, Evalue=7e-66,
Organism=Drosophila melanogaster, GI17137316, Length=328, Percent_Identity=42.9878048780488, Blast_Score=247, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36939; Mature: 36939

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGL
CCEEHHHCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHEEEEECCCCCC
AAGLDKNGECIEAFDAMGFGFVEVGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGV
EECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCH
DNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICMEKVYEYAGYIAVNISSPNTPG
HHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GVIATNTTLDRTMVEGMKHAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDS
EEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMLAGADLVQVYSGFIYHGPGLVRDIVKNL
HHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGL
CCEEHHHCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHEEEEECCCCCC
AAGLDKNGECIEAFDAMGFGFVEVGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGV
EECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCH
DNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICMEKVYEYAGYIAVNISSPNTPG
HHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GVIATNTTLDRTMVEGMKHAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDS
EEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMLAGADLVQVYSGFIYHGPGLVRDIVKNL
HHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA