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The map label for this gene is copA [H]

Identifier: 27365909

GI number: 27365909

Start: 2651280

End: 2653649

Strand: Reverse

Name: copA [H]

Synonym: VV1_2614

Alternate gene names: 27365909

Gene position: 2653649-2651280 (Counterclockwise)

Preceding gene: 27365910

Following gene: 27365908

Centisome position: 80.86

GC content: 45.86

Gene sequence:

>2370_bases
ATGACACAATCCTGTTATCACTGTGGTGAAGATGTACCGGTCAACACGGATTTTAAAGTTGAAATCTTAGGTGAAACTCG
CGAAATGTGTTGCCCAGGTTGTGAGACCGTGGCGCAAACAATCGTGGATAATGGCCTCGTTTCTTATTACCAATATCGAA
CCGCGCCAGCAGAAAAAGTGGAGTTGGTGCCTGAGCAACTCAAGGCCCTCATTCATTACGACAACGAGGAAGTTCAAGCC
GAGTTTGTGCGCAGCAACGACAATTATTGTGAAGTGATGCTTTCTTTAGAAGGCGTTTCTTGTGCGGCGTGCGCGTGGTT
AATTGAAAAACAAGTGAATGGTCAAACGGGTGTGGTGTCAATTAAGGTAAATACCACCACGAATCGAGCACTGCTCTCTT
GGGATAAATCCAAAACAAAACTGAGTGAGCTTCTTTCCGGCATTCATGCTCTAGGCTACAAAGCCGCCCCTTTTGAAGCG
GATAAACAAGAGGCCTCATATCATGCGACGATGAAGCAGTATCTTTATCGACTCGGCATAGCGGGACTGGCGACAATGCA
AGTGATGATGCTGGCCGTTGCATTGTATTTGGAAGTTTTTGGCGATCTTGAACCAGAGTTTAAGAATTACTTTCGTTGGG
TGAGTTTGATTTTTGCAACACCAGTGTTGCTTTACTCTGCCCTACCATTTTACCTAAATGCTTGGCGCAGTATTAAAGGA
AGAACCTTGGGGATGGATGTGCCTGTATCCATTGCCTTGATTTTTGCATATTGTGCGAGCTTAGTGGCAACCGTCACAGA
ACAAGGGGAAGTGTTTTTTGAGTCCATCTCAATGTTCACTTTTTTCTTGTTAGTTGGGCGCTTTTTAGAAATGCGAGCTC
GTCGAAAAGCGGCGGCTGCAAGTGGTAATTTGCTTAAACTGATTCCTGCTATCGCCACAACGTTGGATGGCAAGCAAGTG
CCGGTAAAGAGCTTAAAAATTGGTGATCAAGTCCGAGTTTTACCCGGTGAGCATATACCCGCCGATGGTTTTGTCGTTGA
AGGACGAATCCATATTGACGAATCAATGCTAACTGGAGAATCAGTGCATGTCGTCAAGCGCGCTGATGACGCTGTTTTTG
CTGGTACCCTCAATGGCGATGAGTCGTTTGTTTTGCAGGTAACGAGCTCGAAAGCGGATTCGGTGATTTCTAATATCGTT
CGGCTTCAAGATGAAGCGCAGCACTCTAAGCCCAAAATTGCCGAAGTGGCAGACGTAGTGGCGCGTTATTTTGTTGGTGC
TATTTTGCTTATTTCCGCAGCCACTTGGTTCTATTGGCACCAAACAAAACCTGAGGACGCATTTTGGATTATGCTGTCTG
TTCTTGTGGCGACTTGCCCATGCGCGCTTTCTCTTGCAACACCAACGGCACTAACGTGCGCCACGTCTCGAATGGGTAAC
TTTGGTATCCTATTGCGAAAAGGACATGTATTTGAAACCTTGTGTAAAGTTAACCATTTAGTGATCGATAAAACAGGCAC
GCTGACCAAAGGCGACATTGAAATCGAAGATACAAAAACCTTCGATGAGTTCAATAAAGGAACGTGTCTTGCGTTAGCAG
CTAGCTTAGAAAGCCATGCCAATCACCCTATTGCCCGTGCTTTCAAACCTTATTTTGATACAGATTTCCAGGTTAGTGAT
GTGGTCAACATCATTGGCTCCGGCATTTCCGGAACTTGGGATAATAAGGCGATAAACATTGGCAGCGCGGCGTTCGTTCT
AGGTAGAGCCGCATTAGAAAAAAATGCGGTTTATATGTCCATTGATGGTAAGCATGTGGCAACATTCTATTACCATGATC
CAGTTCGGAAAGAGAGCCACAAGCTCATTGAAAAGTTTGCCCAAGCAGGTATCAAAACCACTTTGTTAACGGGAGACTCG
GCTGCCAATGCTGAGGGTGTCGCAAAGGCCGTTGGAATTGAGCACGTTATCGCGTCAGCGAAACCGGAGGATAAACTAGC
GTATCTCAAAGGATTGGAAGAGAACGATATCACGATGATGGTTGGTGACGGCATCAACGATGCTCCAACACTAGCTGGTG
CGCATTTATCTGTAGCAATGGGCAGTGGTACTGATGTCGCTAAGGCGTCTGCTGATATGACGCTGCTTGGGGATCGTTTA
GATAAGCTCCTAGAGGCTCGAGAGTTGGCGTTAAGAGCTCGACGAATCATAAAGGAAAATCTCGCTTGGTCATTGGGTTA
TAACCTATTGATTCTACCTTTGGCTGTCGCTGGTTTGGTTGCGCCTTATATTGCGGTTGTAGGAATGTCTGGTAGCTCTA
TAATAGTGGTCTCTAACTCCTTAAGACTGCTCAAAGAGCGTGGAAAGTAA

Upstream 100 bases:

>100_bases
GGGCCTTGGTTTATTGAGCTTCAACCACATGACCAAAAGTGGTTAGTTCAAGGTCGCGTTACTTTCCCTTCTTCCGCAAC
TGTTTTGATGAACTAAGACT

Downstream 100 bases:

>100_bases
ACAATGGAAAGTTTGTATCTTCTTATCCCAATTGCAATTGTGTTGGTTTGTGTTGCTGTAGCGATATTTCTTTGGGCGGT
AAAAAGCGAGCAGTTTGAAG

Product: copper-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MTQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKVELVPEQLKALIHYDNEEVQA
EFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVSIKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEA
DKQEASYHATMKQYLYRLGIAGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAASGNLLKLIPAIATTLDGKQV
PVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGESVHVVKRADDAVFAGTLNGDESFVLQVTSSKADSVISNIV
RLQDEAQHSKPKIAEVADVVARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEIEDTKTFDEFNKGTCLALAASLESHANHPIARAFKPYFDTDFQVSD
VVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMSIDGKHVATFYYHDPVRKESHKLIEKFAQAGIKTTLLTGDS
AANAEGVAKAVGIEHVIASAKPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
DKLLEARELALRARRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNSLRLLKERGK

Sequences:

>Translated_789_residues
MTQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKVELVPEQLKALIHYDNEEVQA
EFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVSIKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEA
DKQEASYHATMKQYLYRLGIAGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAASGNLLKLIPAIATTLDGKQV
PVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGESVHVVKRADDAVFAGTLNGDESFVLQVTSSKADSVISNIV
RLQDEAQHSKPKIAEVADVVARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEIEDTKTFDEFNKGTCLALAASLESHANHPIARAFKPYFDTDFQVSD
VVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMSIDGKHVATFYYHDPVRKESHKLIEKFAQAGIKTTLLTGDS
AANAEGVAKAVGIEHVIASAKPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
DKLLEARELALRARRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNSLRLLKERGK
>Mature_788_residues
TQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKVELVPEQLKALIHYDNEEVQAE
FVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVSIKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEAD
KQEASYHATMKQYLYRLGIAGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKGR
TLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAASGNLLKLIPAIATTLDGKQVP
VKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGESVHVVKRADDAVFAGTLNGDESFVLQVTSSKADSVISNIVR
LQDEAQHSKPKIAEVADVVARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGNF
GILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEIEDTKTFDEFNKGTCLALAASLESHANHPIARAFKPYFDTDFQVSDV
VNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMSIDGKHVATFYYHDPVRKESHKLIEKFAQAGIKTTLLTGDSA
ANAEGVAKAVGIEHVIASAKPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRLD
KLLEARELALRARRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNSLRLLKERGK

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=823, Percent_Identity=27.9465370595383, Blast_Score=279, Evalue=8e-75,
Organism=Homo sapiens, GI115529486, Length=866, Percent_Identity=26.4434180138568, Blast_Score=236, Evalue=9e-62,
Organism=Homo sapiens, GI55743073, Length=602, Percent_Identity=27.906976744186, Blast_Score=197, Evalue=4e-50,
Organism=Escherichia coli, GI1786691, Length=848, Percent_Identity=29.8349056603774, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1789879, Length=724, Percent_Identity=29.4198895027624, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786914, Length=448, Percent_Identity=29.0178571428571, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17556548, Length=516, Percent_Identity=27.906976744186, Blast_Score=182, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6320475, Length=738, Percent_Identity=28.4552845528455, Blast_Score=276, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319772, Length=669, Percent_Identity=28.8490284005979, Blast_Score=248, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6321430, Length=528, Percent_Identity=21.969696969697, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325221, Length=549, Percent_Identity=22.040072859745, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321271, Length=148, Percent_Identity=34.4594594594595, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221329854, Length=547, Percent_Identity=28.7020109689214, Blast_Score=190, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24668708, Length=145, Percent_Identity=31.7241379310345, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281366617, Length=145, Percent_Identity=31.7241379310345, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668704, Length=145, Percent_Identity=31.7241379310345, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161085803, Length=180, Percent_Identity=29.4444444444444, Blast_Score=67, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24668696, Length=145, Percent_Identity=31.7241379310345, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 85929; Mature: 85798

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKV
CCCCCHHCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHH
ELVPEQLKALIHYDNEEVQAEFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVS
HHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEE
IKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEADKQEASYHATMKQYLYRLGI
EEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLLKLIPAIATTLDGKQVPVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGE
CCCHHHHHHHHHHHCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHCCC
SVHVVKRADDAVFAGTLNGDESFVLQVTSSKADSVISNIVRLQDEAQHSKPKIAEVADVV
CEEEEEECCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCC
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEIEDTKTFDEFNKGTCLALAASLESHA
CEEEEECCHHHHHHHHHCCEEEECCCCEEECCEEEECCCCHHHCCCCCHHHHHHHHHHHC
NHPIARAFKPYFDTDFQVSDVVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMS
CCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEE
IDGKHVATFYYHDPVRKESHKLIEKFAQAGIKTTLLTGDSAANAEGVAKAVGIEHVIASA
ECCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC
KPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCHHHHHHHH
DKLLEARELALRARRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECC
LRLLKERGK
HHHHHHCCC
>Mature Secondary Structure 
TQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKV
CCCCHHCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHH
ELVPEQLKALIHYDNEEVQAEFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVS
HHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEE
IKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEADKQEASYHATMKQYLYRLGI
EEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLLKLIPAIATTLDGKQVPVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGE
CCCHHHHHHHHHHHCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHCCC
SVHVVKRADDAVFAGTLNGDESFVLQVTSSKADSVISNIVRLQDEAQHSKPKIAEVADVV
CEEEEEECCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCC
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEIEDTKTFDEFNKGTCLALAASLESHA
CEEEEECCHHHHHHHHHCCEEEECCCCEEECCEEEECCCCHHHCCCCCHHHHHHHHHHHC
NHPIARAFKPYFDTDFQVSDVVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMS
CCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEE
IDGKHVATFYYHDPVRKESHKLIEKFAQAGIKTTLLTGDSAANAEGVAKAVGIEHVIASA
ECCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC
KPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCHHHHHHHH
DKLLEARELALRARRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECC
LRLLKERGK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA