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The map label for this gene is hutU [H]

Identifier: 27365709

GI number: 27365709

Start: 2427993

End: 2429690

Strand: Reverse

Name: hutU [H]

Synonym: VV1_2390

Alternate gene names: 27365709

Gene position: 2429690-2427993 (Counterclockwise)

Preceding gene: 27365710

Following gene: 27365708

Centisome position: 74.03

GC content: 53.12

Gene sequence:

>1698_bases
ATGACACAGAGCCAAGGACAAGATCCTCGCCTAGACACCAGCCGAACCATTCGCGCCCCTCATGGCACCACGCTAAGAGC
CAAGTCATGGTTGACCGAAGCGCCATTGCGCATGCTGATGAATAATTTGGATCCTGATGTGGCTGAGCATCCGCACGCCT
TAGTGGTGTATGGCGGCATTGGGCGTGCTGCACGCAATTGGGCATGCTTCGACAAGATTGTTGAAGTGCTTGAGCGTCTG
GAAGACGACCAAACTTTGTTGGTTCAATCAGGTAAACCTGTGGGTGTCTTCCCTACGCATAAAAATGCACCACGCGTGCT
GATCGCCAACTCTAACCTGGTTCCACACTGGGCAAACTGGGAACACTTCAATGAGCTCGATAAACAAGGCTTGATGATGT
ATGGCCAAATGACCGCGGGCAGCTGGATCTACATCGGCTCTCAAGGCATCGTACAGGGTACCTACGAAACCTTCGTCGCT
GTTGCAAAAAAACACTTCGCCGGTGAAGCAAAAGGTCGTTGGGTACTCACTGGTGGTCTTGGTGGCATGGGCGGCGCACA
GCCACTTGCTGCAACCATGGCTGGCTTCTCGATGATTGCCGTTGAATGTGATGAATCGCGTATCGATTATCGCCTACGTA
CGGGTTATGTCGATAAGAAAGCGACCACCCTAGAGGAAGCGTTGGCCATCGTCAAAGAATCCGACACGCCTGTCTCTGTT
GGCTTACTGGGTAACGCCGCCGATGTGTTCGCAGAATTGGTGGAGCGCAACATCACGCCCGATGTCGTCACCGATCAAAC
CTCGGCACATGACCCGTTGAATGGCTACTTACCGCAAGGCTGGAGTATGGCCTACGCAGCGGAAATGCGTCAGCAAGACG
AGAGCACTGTCGTCAAAGCCGCAAAACAGTCCATGGCGGTTCAAGTCAAAGCCATGCTTGAACTGCAAAGTCGTGGAGCC
GCCACGCTCGATTACGGCAACAACATTCGTCAAATGGCGCTAGAAGAAGGGGTCGAGAATGCATTTGATTTCCCGGGCTT
TGTGCCAGCATATATTCGACCTTTGTTCTGCGAAGGCATTGGCCCTTTCCGCTGGGCGGCGCTGTCGGGCGATCCTGAGG
ACATTTACAAAACAGACCAAAAAGTGAAAGAGCTGATTCCTGACAATCCTCATCTGCACAATTGGTTAGACATGGCACGC
GAGCGAATTCAATTCCAAGGTTTACCCGCACGTATTTGCTGGGTGGGTCTGAAAGATCGCGAACGCCTAGGCCAGGCATT
TAATGAAATGGTGAAAAATGGCGAACTAAAAGCGCCGATCGTGATTGGTCGTGATCATCTAGATTCGGGTTCCGTCGCCA
GCCCAAACCGTGAAACGGAAGGCATGATGGACGGTTCAGACGCGGTTTCTGACTGGCCACTGCTCAATGCCCTCCTCAAT
ACCGCCGGTGGTGCGACTTGGGTATCACTCCATCATGGTGGTGGTGTAGGCATGGGCTTCTCGCAACACTCTGGAATGGT
AATTTGCTGTGACGGAACAGAAGATGCGTCAGCGCGTATTGCCCGAGTGCTGCATAACGATCCTGCAACGGGAGTGATGC
GCCACGCCGATGCGGGTTACGACATCGCCAAACAGTGCGCAGCGCAGCAAGGTCTTGACCTGCCGATGCTGAACGAAGAA
TTGAGCAAGTTGAAGTAA

Upstream 100 bases:

>100_bases
TTGCCAACGCCATGAACGACAAACTCGAACATCAATAAACAGAACAACAATCAGGTGAACCGATGAGTTCACCGCTACGT
GAAATTAAAGGAGTCTTACA

Downstream 100 bases:

>100_bases
GGAATATGGATATGTTAAATCTCACGCTAAAGCCCGGTTGTCTTAGCTTAAATCAACTGCGTCAAGTCAGTCGTTCCCCG
ATCAATCTTTCTCTTGATGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MTQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARNWACFDKIVEVLERL
EDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVA
VAKKHFAGEAKGRWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLEEALAIVKESDTPVSV
GLLGNAADVFAELVERNITPDVVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESTVVKAAKQSMAVQVKAMLELQSRGA
ATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMAR
ERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGYDIAKQCAAQQGLDLPMLNEE
LSKLK

Sequences:

>Translated_565_residues
MTQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARNWACFDKIVEVLERL
EDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVA
VAKKHFAGEAKGRWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLEEALAIVKESDTPVSV
GLLGNAADVFAELVERNITPDVVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESTVVKAAKQSMAVQVKAMLELQSRGA
ATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMAR
ERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGYDIAKQCAAQQGLDLPMLNEE
LSKLK
>Mature_564_residues
TQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARNWACFDKIVEVLERLE
DDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAV
AKKHFAGEAKGRWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLEEALAIVKESDTPVSVG
LLGNAADVFAELVERNITPDVVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESTVVKAAKQSMAVQVKAMLELQSRGAA
TLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARE
RIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLNT
AGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGYDIAKQCAAQQGLDLPMLNEEL
SKLK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=548, Percent_Identity=34.3065693430657, Blast_Score=301, Evalue=2e-81,
Organism=Homo sapiens, GI260306182, Length=203, Percent_Identity=38.9162561576355, Blast_Score=159, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71997891, Length=583, Percent_Identity=34.4768439108062, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61677; Mature: 61545

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCC
GRAARNWACFDKIVEVLERLEDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANW
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCC
EHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAVAKKHFAGEAKGRWVLTGGL
HHHHHHHHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLEEALAIVKESDTPVSV
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEE
GLLGNAADVFAELVERNITPDVVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESTVVKA
EECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKQSMAVQVKAMLELQSRGAATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGI
HHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
GPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDR
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCH
ERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGY
CCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHCCCCH
DIAKQCAAQQGLDLPMLNEELSKLK
HHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TQSQGQDPRLDTSRTIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGI
CCCCCCCCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCC
GRAARNWACFDKIVEVLERLEDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANW
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCC
EHFNELDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAVAKKHFAGEAKGRWVLTGGL
HHHHHHHHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDKKATTLEEALAIVKESDTPVSV
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEE
GLLGNAADVFAELVERNITPDVVTDQTSAHDPLNGYLPQGWSMAYAAEMRQQDESTVVKA
EECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKQSMAVQVKAMLELQSRGAATLDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGI
HHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
GPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDR
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCH
ERLGQAFNEMVKNGELKAPIVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGTEDASARIARVLHNDPATGVMRHADAGY
CCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHCCCCH
DIAKQCAAQQGLDLPMLNEELSKLK
HHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA