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The map label for this gene is aqpZ

Identifier: 27365352

GI number: 27365352

Start: 2006789

End: 2007484

Strand: Reverse

Name: aqpZ

Synonym: VV1_2010

Alternate gene names: 27365352

Gene position: 2007484-2006789 (Counterclockwise)

Preceding gene: 326423921

Following gene: 326423920

Centisome position: 61.17

GC content: 53.45

Gene sequence:

>696_bases
ATGAATAAATATCTGGCGGAATTATTTGGCACCTTTTGGCTGGTGCTTGGTGGATGTGGCAGTGCCGTGTTGGCGGCCGC
CTTTCCGGACGTTGGGATTGGCCTGCTAGGCGTATCCCTCGCGTTCGGTTTGACGGTGCTCACCATGGCTTTTGCTATCG
GCCATATTTCCGGCTGCCACTTGAACCCTGCCGTCACCATTGGCTTATGGGCCGGTGGTCGATTTGAAGCCAAAGAAATT
GTGCCTTATATCCTTGCTCAAGTGATTGGTGGCGTCATTGCCGGTGGTGTGCTTTATACCATCGCCTCTGGTCAAATGGG
CTTCGATGCGACGAGCTCGGGTTTTGCCTCTAACGGTTATGGTGAGCATTCTCCCGGTGGCTATTCGCTGACTTCTGCGC
TGGTGACCGAAGTCGTGATGACCATGATGTTTTTGCTGGTGATTCTTGGCGCAACAGATCAGCGTGCACCTCAAGGTTTT
GCGCCCATCGCTATCGGTCTGTGCCTCACACTTATCCACCTCATCAGCATTCCAGTGACCAATACATCGGTCAACCCTGC
TCGAAGTACCGGCGTTGCTCTCTATGTTGGCGATTGGGCCACCGCGCAACTTTGGCTATTCTGGGTTGCGCCGATTTTAG
GCGCACTACTAGGGGCGGTGGCCTACAAGTTGATTTCAGGGTCGAACAAAGACTAA

Upstream 100 bases:

>100_bases
CCAAGGAGAATTTCGCGACACAATATCACGACACTTTCTAGCAAGGTGCTGATTGTCGGCTATTTTTATTCCAATACTCC
CCCTCTCAATAGGACATTGT

Downstream 100 bases:

>100_bases
TCACAGCGAGCCGCCGATTCGAGCGGCTCTTTTTCTATTGCTTCTTAATATTTTATAAAACACATCACAACTTTGTGACT
TGGTCACAAATGGTCACAGA

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVTIGLWAGGRFEAKEI
VPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGYGEHSPGGYSLTSALVTEVVMTMMFLLVILGATDQRAPQGF
APIAIGLCLTLIHLISIPVTNTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD

Sequences:

>Translated_231_residues
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVTIGLWAGGRFEAKEI
VPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGYGEHSPGGYSLTSALVTEVVMTMMFLLVILGATDQRAPQGF
APIAIGLCLTLIHLISIPVTNTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD
>Mature_231_residues
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVTIGLWAGGRFEAKEI
VPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGYGEHSPGGYSLTSALVTEVVMTMMFLLVILGATDQRAPQGF
APIAIGLCLTLIHLISIPVTNTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family

Homologues:

Organism=Homo sapiens, GI37694062, Length=191, Percent_Identity=37.696335078534, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4502183, Length=225, Percent_Identity=35.1111111111111, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4502179, Length=223, Percent_Identity=32.2869955156951, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI6912506, Length=223, Percent_Identity=32.7354260089686, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI4755125, Length=198, Percent_Identity=32.8282828282828, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI4502181, Length=198, Percent_Identity=32.8282828282828, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI86792455, Length=226, Percent_Identity=29.2035398230088, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI157266307, Length=239, Percent_Identity=29.7071129707113, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4826645, Length=249, Percent_Identity=26.9076305220884, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI45446752, Length=205, Percent_Identity=28.2926829268293, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4502187, Length=251, Percent_Identity=28.2868525896414, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI22538420, Length=248, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI297307120, Length=91, Percent_Identity=38.4615384615385, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI297307116, Length=91, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI297307118, Length=91, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=75, Blast_Score=314, Evalue=3e-87,
Organism=Escherichia coli, GI1790362, Length=251, Percent_Identity=28.6852589641434, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=237, Percent_Identity=28.2700421940928, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17558372, Length=207, Percent_Identity=28.0193236714976, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=244, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994009, Length=250, Percent_Identity=24, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24652747, Length=228, Percent_Identity=33.7719298245614, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45551084, Length=228, Percent_Identity=33.7719298245614, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45550503, Length=230, Percent_Identity=29.1304347826087, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24652751, Length=191, Percent_Identity=35.6020942408377, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922038, Length=191, Percent_Identity=35.0785340314136, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136672, Length=231, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24762342, Length=200, Percent_Identity=27.5, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24762346, Length=228, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24762348, Length=228, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI20130305, Length=228, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24762344, Length=228, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AQPZ_VIBVU (Q8DB17)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_760880.1
- ProteinModelPortal:   Q8DB17
- SMR:   Q8DB17
- GeneID:   1178906
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_2010
- HOGENOM:   HBG705794
- OMA:   GFGEHSP
- ProtClustDB:   PRK05420
- BioCyc:   VVUL216895:VV1_2010-MONOMER
- HAMAP:   MF_01146
- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357
- PANTHER:   PTHR19139
- PRINTS:   PR00783
- TIGRFAMs:   TIGR00861

Pfam domain/function: PF00230 MIP

EC number: NA

Molecular weight: Translated: 23768; Mature: 23768

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00221 MIP; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe761408)-; HASH(0xf3518d4)-; HASH(0xdd16170)-; HASH(0xe9f5074)-; HASH(0xdd15a38)-; HASH(0xf16d0d0)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCH
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVTIGLWAGGRFEAKEIVPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGY
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GEHSPGGYSLTSALVTEVVMTMMFLLVILGATDQRAPQGFAPIAIGLCLTLIHLISIPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCH
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVTIGLWAGGRFEAKEIVPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGY
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GEHSPGGYSLTSALVTEVVMTMMFLLVILGATDQRAPQGFAPIAIGLCLTLIHLISIPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA