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The map label for this gene is edd [H]

Identifier: 27364522

GI number: 27364522

Start: 1098690

End: 1100486

Strand: Reverse

Name: edd [H]

Synonym: VV1_1099

Alternate gene names: 27364522

Gene position: 1100486-1098690 (Counterclockwise)

Preceding gene: 27364523

Following gene: 27364519

Centisome position: 33.53

GC content: 55.7

Gene sequence:

>1797_bases
ATGACCCATCCCATCATTTTAGAGGTCACTCAGCGCTTGGTGGAACGCAGCCAGGCAACACGTGCGGCGTTTGTTGCACG
CACCGAAGAGCAAGCCAAAGCGGGCAAAGGACGTGTTGGTTTATCGTGTGGCAACTTAGCGCACGCGGTGGCGGCGTCTT
GTTCAGCAGAAAAGAAAAACATCCTCGATTTTACTCATGCCAATGTGGCGCTGATCAGCGCCTACAACGACATGCTCAGC
GCCCACCAGCCTTACCAGCACTACCCAGAGCAAATTAAGCGCGCACTGGCAGAGTATGGCCATACTGCTCAGGTCGCTGG
CTGTGTCCCTGCGATGTGCGATGGTGTCACTCAAGGCCAAGCGGGCATGGATATGTCGCTGTTTTCTCGTGATCTGATTG
CACAGTCCACAGCCCTCTCTTTGAGCCACAATGTGTTTGATGCCACCTTGCTGCTCGGCATTTGCGACAAAATCGCCCCA
GGGCAACTGATGGGTGCACTGTCTTACGCACACCTGCCTACCGCATTTGTGCCAGCGGGTCTCATGGCGACTGGCATCAG
CAATGAAGAAAAAGTCGATGTTCGCCAAAAATACGCGGCGGGCGAAGTGGGCAAAGACGCGTTGCTTGATATGGAGTGTC
GCGCGTACCACTCCGTTGGCACGTGCACCTTCTACGGCACCGCCAACACCAACCAACTGGTGTTTGAGGCGATGGGATTG
ATGTTACCCGGCTCAGCGTTTATCCATCCAAACTCCGAGCTCCGACACGCGCTCACTGAACACGCGGCGATCAAAATGGC
GGCCATGACCGCCAGCTCGGCTCACTTCCGCTCACTGGCTGAAGTGGTCACTGAAAAGAGCCTGATCAACGGCATCATTG
CCCTACTTGCTTCCGGTGGCAGCACCAACCACACCATTCACATGTTGGCTGTGGCGCGCGCTGCGGGTATTGAGCTCACT
TGGCAAGACATCAGTGATCTTTCTGACGTGGTACCGCTGCTAGCACGCGTATACCCGAACGGCCCCGCTGACATGAACGC
CTTCCAACAAGCGGGTGGCGTGCCTGCGCTGCTGCATCGTCTCAATGAATCGGCTCTGCTGCATCGTGACGTCAAGCCAG
TGTTTGGCGAGTTCGACGACCAAATGAGCCTACCAAGCCTTGTCGACGGCAAGCTCGTTTGGACACCATGTGAGGGCACC
TTCGATAGCCATGTGATCGCCGACAAATGCTGTGTTTTCCAATCCACAGGCGGCACAAAAGTGCTGACTGGCAATTTGGG
CAAAGCGGTGGTGAAAGTCTCTGCGGTGAAAGAAGATCAGCGCGTGATTGAAGCGCCAGCGCTGGTGTTCCAGTGCCAAC
ATGAGGTGGAAGCGGCGTACCAACGTGGTGAGCTCAACCGAGATTGCATTGTGGTGGTGACGCACAATGGCCCAGCTGCC
AATGGCATGCCAGAGCTACACAAGTTGATGCCGATTCTCGGCAATGTGCAAAAGGCGGGCTTTAAAGTGGCGCTGGTGAC
CGATGGCCGTTTGTCTGGCGCTTCAGGTAAAATCCCATCGGCCATTCACGTCTCTCCAGAAGCGATTCGTGGCGGCGCGA
TTGGCTTAGTGCGTAATGGTGATGTAATTCGTGTCGATTGCCAGACAGGCGAGTTAAACAACCTCAGCGACACCACAGGT
CGCTGCATGCTTGAAATCGATACCGAGGCAAGCCAGCAAACTTGGGGACGCAATCTGTTCAGCACCCTTCGCCAATCGGT
GTCTAGCGCCGAACACGGTGCGAGTTTTATCGTCTGA

Upstream 100 bases:

>100_bases
ATGGTGAACCTCGCACTCTATTGGTGAGCATTGATACCACTATCGAAGAGGTTGTCACCAACGCGGCCGAGTTAATTCTA
GAGCAAGATGAGGCACAAGC

Downstream 100 bases:

>100_bases
TCAACAAGGGCGCGTTTATCGCGCCCTTGCTTTTAATCACATCGACTGAGTTACACACTCTCGCCAGCGGTAATGCGGTA
GCCCATATCCACCACATTTT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MTHPIILEVTQRLVERSQATRAAFVARTEEQAKAGKGRVGLSCGNLAHAVAASCSAEKKNILDFTHANVALISAYNDMLS
AHQPYQHYPEQIKRALAEYGHTAQVAGCVPAMCDGVTQGQAGMDMSLFSRDLIAQSTALSLSHNVFDATLLLGICDKIAP
GQLMGALSYAHLPTAFVPAGLMATGISNEEKVDVRQKYAAGEVGKDALLDMECRAYHSVGTCTFYGTANTNQLVFEAMGL
MLPGSAFIHPNSELRHALTEHAAIKMAAMTASSAHFRSLAEVVTEKSLINGIIALLASGGSTNHTIHMLAVARAAGIELT
WQDISDLSDVVPLLARVYPNGPADMNAFQQAGGVPALLHRLNESALLHRDVKPVFGEFDDQMSLPSLVDGKLVWTPCEGT
FDSHVIADKCCVFQSTGGTKVLTGNLGKAVVKVSAVKEDQRVIEAPALVFQCQHEVEAAYQRGELNRDCIVVVTHNGPAA
NGMPELHKLMPILGNVQKAGFKVALVTDGRLSGASGKIPSAIHVSPEAIRGGAIGLVRNGDVIRVDCQTGELNNLSDTTG
RCMLEIDTEASQQTWGRNLFSTLRQSVSSAEHGASFIV

Sequences:

>Translated_598_residues
MTHPIILEVTQRLVERSQATRAAFVARTEEQAKAGKGRVGLSCGNLAHAVAASCSAEKKNILDFTHANVALISAYNDMLS
AHQPYQHYPEQIKRALAEYGHTAQVAGCVPAMCDGVTQGQAGMDMSLFSRDLIAQSTALSLSHNVFDATLLLGICDKIAP
GQLMGALSYAHLPTAFVPAGLMATGISNEEKVDVRQKYAAGEVGKDALLDMECRAYHSVGTCTFYGTANTNQLVFEAMGL
MLPGSAFIHPNSELRHALTEHAAIKMAAMTASSAHFRSLAEVVTEKSLINGIIALLASGGSTNHTIHMLAVARAAGIELT
WQDISDLSDVVPLLARVYPNGPADMNAFQQAGGVPALLHRLNESALLHRDVKPVFGEFDDQMSLPSLVDGKLVWTPCEGT
FDSHVIADKCCVFQSTGGTKVLTGNLGKAVVKVSAVKEDQRVIEAPALVFQCQHEVEAAYQRGELNRDCIVVVTHNGPAA
NGMPELHKLMPILGNVQKAGFKVALVTDGRLSGASGKIPSAIHVSPEAIRGGAIGLVRNGDVIRVDCQTGELNNLSDTTG
RCMLEIDTEASQQTWGRNLFSTLRQSVSSAEHGASFIV
>Mature_597_residues
THPIILEVTQRLVERSQATRAAFVARTEEQAKAGKGRVGLSCGNLAHAVAASCSAEKKNILDFTHANVALISAYNDMLSA
HQPYQHYPEQIKRALAEYGHTAQVAGCVPAMCDGVTQGQAGMDMSLFSRDLIAQSTALSLSHNVFDATLLLGICDKIAPG
QLMGALSYAHLPTAFVPAGLMATGISNEEKVDVRQKYAAGEVGKDALLDMECRAYHSVGTCTFYGTANTNQLVFEAMGLM
LPGSAFIHPNSELRHALTEHAAIKMAAMTASSAHFRSLAEVVTEKSLINGIIALLASGGSTNHTIHMLAVARAAGIELTW
QDISDLSDVVPLLARVYPNGPADMNAFQQAGGVPALLHRLNESALLHRDVKPVFGEFDDQMSLPSLVDGKLVWTPCEGTF
DSHVIADKCCVFQSTGGTKVLTGNLGKAVVKVSAVKEDQRVIEAPALVFQCQHEVEAAYQRGELNRDCIVVVTHNGPAAN
GMPELHKLMPILGNVQKAGFKVALVTDGRLSGASGKIPSAIHVSPEAIRGGAIGLVRNGDVIRVDCQTGELNNLSDTTGR
CMLEIDTEASQQTWGRNLFSTLRQSVSSAEHGASFIV

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=600, Percent_Identity=56.1666666666667, Blast_Score=672, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=529, Percent_Identity=28.9224952741021, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI2367371, Length=516, Percent_Identity=30.2325581395349, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI1786464, Length=461, Percent_Identity=30.1518438177874, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6322476, Length=511, Percent_Identity=29.5499021526419, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 63653; Mature: 63522

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPIILEVTQRLVERSQATRAAFVARTEEQAKAGKGRVGLSCGNLAHAVAASCSAEKKN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECCCHHHHHHHHHCCCCHHH
ILDFTHANVALISAYNDMLSAHQPYQHYPEQIKRALAEYGHTAQVAGCVPAMCDGVTQGQ
CCEECCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCHHHHHCCCCCCC
AGMDMSLFSRDLIAQSTALSLSHNVFDATLLLGICDKIAPGQLMGALSYAHLPTAFVPAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCC
LMATGISNEEKVDVRQKYAAGEVGKDALLDMECRAYHSVGTCTFYGTANTNQLVFEAMGL
HHHCCCCCCHHHHHHHHHHCCCCCCHHHCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHH
MLPGSAFIHPNSELRHALTEHAAIKMAAMTASSAHFRSLAEVVTEKSLINGIIALLASGG
HCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
STNHTIHMLAVARAAGIELTWQDISDLSDVVPLLARVYPNGPADMNAFQQAGGVPALLHR
CCCCEEEEEEEHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHH
LNESALLHRDVKPVFGEFDDQMSLPSLVDGKLVWTPCEGTFDSHVIADKCCVFQSTGGTK
CCHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHEEEECCCCCE
VLTGNLGKAVVKVSAVKEDQRVIEAPALVFQCQHEVEAAYQRGELNRDCIVVVTHNGPAA
EEECCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
NGMPELHKLMPILGNVQKAGFKVALVTDGRLSGASGKIPSAIHVSPEAIRGGAIGLVRNG
CCCHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCCCCCCCEEECCHHHHCCCCEEEEECC
DVIRVDCQTGELNNLSDTTGRCMLEIDTEASQQTWGRNLFSTLRQSVSSAEHGASFIV
CEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
THPIILEVTQRLVERSQATRAAFVARTEEQAKAGKGRVGLSCGNLAHAVAASCSAEKKN
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECCCHHHHHHHHHCCCCHHH
ILDFTHANVALISAYNDMLSAHQPYQHYPEQIKRALAEYGHTAQVAGCVPAMCDGVTQGQ
CCEECCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCHHHHHCCCCCCC
AGMDMSLFSRDLIAQSTALSLSHNVFDATLLLGICDKIAPGQLMGALSYAHLPTAFVPAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCC
LMATGISNEEKVDVRQKYAAGEVGKDALLDMECRAYHSVGTCTFYGTANTNQLVFEAMGL
HHHCCCCCCHHHHHHHHHHCCCCCCHHHCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHH
MLPGSAFIHPNSELRHALTEHAAIKMAAMTASSAHFRSLAEVVTEKSLINGIIALLASGG
HCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
STNHTIHMLAVARAAGIELTWQDISDLSDVVPLLARVYPNGPADMNAFQQAGGVPALLHR
CCCCEEEEEEEHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHH
LNESALLHRDVKPVFGEFDDQMSLPSLVDGKLVWTPCEGTFDSHVIADKCCVFQSTGGTK
CCHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHEEEECCCCCE
VLTGNLGKAVVKVSAVKEDQRVIEAPALVFQCQHEVEAAYQRGELNRDCIVVVTHNGPAA
EEECCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
NGMPELHKLMPILGNVQKAGFKVALVTDGRLSGASGKIPSAIHVSPEAIRGGAIGLVRNG
CCCHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCCCCCCCEEECCHHHHCCCCEEEEECC
DVIRVDCQTGELNNLSDTTGRCMLEIDTEASQQTWGRNLFSTLRQSVSSAEHGASFIV
CEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]