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The map label for this gene is trx [H]

Identifier: 27364380

GI number: 27364380

Start: 945194

End: 945520

Strand: Reverse

Name: trx [H]

Synonym: VV1_0938

Alternate gene names: 27364380

Gene position: 945520-945194 (Counterclockwise)

Preceding gene: 27364383

Following gene: 27364379

Centisome position: 28.81

GC content: 47.09

Gene sequence:

>327_bases
ATGAGTGACAAGATTTTGCAGCTGTCTGACGAAGGTTTCGAAAACGACGTTATCAACGCTGCAGGCCCAGTACTAGTTGA
TTTTTGGGCAGAATGGTGTGGTCCTTGTAAGATGATTGCCCCAATCCTGGACGAAATCGCAGAAGAGTACGAAGGCAAAC
TCACTATCGGCAAACTGAATATTGACCACAACGCGGGCACACCACCTAAGTTTGGTATTCGTGGCATCCCAACCCTGCTG
CTTTTCAAAAACGGCAGCGTAGCTGCGACGAAAGTGGGCGCACTGTCAAAAACTCAATTGAAAGAGTTTTTGGATGCGAA
CCTATAA

Upstream 100 bases:

>100_bases
ATCAGCTAAAGCTTGCATTAAGAAAGCAAATACATTCCAATAGAGCATCAAATTACTGGTTATCATCCAACCAGTTTCGA
AAAACACATTGGAGTGGAAG

Downstream 100 bases:

>100_bases
TCCATAAGTGATTAATAACAAAACCGTGCAATATCAAAATGCGCGGTTTTGTTTTTTTCAAACTCTGGACTAGAGTTTTA
TTTAGTGCTAATTTATCGCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKILQLSDEGFENDVINAAGPVLVDFWAEWCGPCKMIAPILDEIAEEYEGKLTIGKLNIDHNAGTPPKFGIRGIPTLL
LFKNGSVAATKVGALSKTQLKEFLDANL

Sequences:

>Translated_108_residues
MSDKILQLSDEGFENDVINAAGPVLVDFWAEWCGPCKMIAPILDEIAEEYEGKLTIGKLNIDHNAGTPPKFGIRGIPTLL
LFKNGSVAATKVGALSKTQLKEFLDANL
>Mature_107_residues
SDKILQLSDEGFENDVINAAGPVLVDFWAEWCGPCKMIAPILDEIAEEYEGKLTIGKLNIDHNAGTPPKFGIRGIPTLLL
FKNGSVAATKVGALSKTQLKEFLDANL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=38.0434782608696, Blast_Score=82, Evalue=7e-17,
Organism=Homo sapiens, GI21361657, Length=91, Percent_Identity=36.2637362637363, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=27, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=79.6296296296296, Blast_Score=183, Evalue=2e-48,
Organism=Escherichia coli, GI1788936, Length=107, Percent_Identity=40.1869158878505, Blast_Score=91, Evalue=1e-20,
Organism=Escherichia coli, GI87081747, Length=64, Percent_Identity=40.625, Blast_Score=64, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=43.6619718309859, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=84, Percent_Identity=38.0952380952381, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=34.8837209302326, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=39.0804597701149, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=101, Percent_Identity=35.6435643564356, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=44.047619047619, Blast_Score=73, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=42.2535211267606, Blast_Score=68, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=34.375, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=41.0958904109589, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=34.4827586206897, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=34.0909090909091, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17648013, Length=106, Percent_Identity=31.1320754716981, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583090, Length=106, Percent_Identity=31.1320754716981, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11688; Mature: 11556

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKILQLSDEGFENDVINAAGPVLVDFWAEWCGPCKMIAPILDEIAEEYEGKLTIGKLN
CCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEE
IDHNAGTPPKFGIRGIPTLLLFKNGSVAATKVGALSKTQLKEFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SDKILQLSDEGFENDVINAAGPVLVDFWAEWCGPCKMIAPILDEIAEEYEGKLTIGKLN
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEE
IDHNAGTPPKFGIRGIPTLLLFKNGSVAATKVGALSKTQLKEFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]