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The map label for this gene is 27364220

Identifier: 27364220

GI number: 27364220

Start: 772424

End: 773764

Strand: Reverse

Name: 27364220

Synonym: VV1_0769

Alternate gene names: NA

Gene position: 773764-772424 (Counterclockwise)

Preceding gene: 326423759

Following gene: 27364219

Centisome position: 23.58

GC content: 47.43

Gene sequence:

>1341_bases
ATGCAAGTCATTCACCATGGGGGAAAGGATACCGTCACAGGCTCTTGTCATGAGTTTCGCGCTGCGGGTATCGCGCTCTT
AATCGACTGTGGGCTTTTCCAAGGGAAAGATGCGCGGCCTCCAGAAGTGGATTTCCCTGTCAAACATATTGATGCCTTAG
TGCTGACTCATGCGCATATCGATCATATTGGTCGTATTCCTTGGCTACTTGCCGCAGGATTTTCTGGTTCTATCTACTGT
ACGGAAGCGACTGCTGAACTTGTTCCGCTGATGTTGGAGGATGGGTTAAGGTTACAGCTAGGCTTAAACCACAAGCAGTT
ACACCAAGTGCTCGATTTGGTCAAAAAACGCTTAAAACCTGTGAAGTATGGAGAATGGCTAAGGCTGACTCCTCGCATAA
AAAATGGCAATCGGGCTTCGCGCTCTGTTTCTCATGCTTTAGAAAACTACCTCTATCTGCGTTTTAATCCTGCAGGTCAT
ATACTAGGCTCGGCATATTTGGAGTTTAAGCTACCAAACGACGAAATTGTGGTTTTTTCTGGTGATTTAGGGCCTCGAAA
TACGCCGTTGCTGCCAGATCCCATTTCTCCTCCTCGAGCCGATTATCTGTATATAGAAAGCACTTATGGTGACAAATTGC
ATGAAAGCGTTGAAGAAAGAGGAGAGCGCCTCAAGTCGATCATCAATCGCTCATTGCAAGACGGTGGCACCATCTTGATT
CCGGCGTTTAGTGTGGGCCGCACACAAGAGTTGTTGTTTGATATTGAGCAGTTGATATTTGAGCATAATATCGGCACCGA
CATCCCTATTATTCTCGACTCGCCATTAGCCAAAAGAGTAACTCAATCGTATCGCCGATTTAAAAAACTATGGGGAAAGG
AGGCGAAGCGGCGGCTGGAGGTTCATCGTCATCCTTTGGCCTTTGAGCAGTGCATAACGATAGATGATTATCGCCAACAT
AAAGCATTAGTGAATCGTCTCGCATCAACGGGGGAGCCAGCGATTGTGGTTGCTGCATCTGGCATGTGCCAAGGTGGCCG
GATTATGGACTATCTCCAAGCGTTGTTGCCAGATGAGCGTACGGATGTGTTGTTTGCTGGATATCAGGCGAGCGGTACTT
TGGGGCGTGAGATTCAGACTGGTGAGAAAATGGTACAAATTGAGCAGAAAATGGTGGAGGTTCGCGCTCAGATACATACG
ATGTCTGGCTACTCGGCCCATGCAGACCAAGCCGATCTACTGGCGTTTATTCAAGGTATTGCGCAAAAGCCGAAGGAGAT
CCATTTGATCCATGGTGAAGACGATGCAAAACAAAGTTTGCTTGGAGCTATGCGGTTCTAG

Upstream 100 bases:

>100_bases
GGATGTGTATAAAAATCTCCGTACTACGATCCGATAAGTGCGTTATTAGCTTTGTGCCGTTTCGTTGTGAAGGAGTGCTT
TAGGGGAGCAAGGAGTAAGC

Downstream 100 bases:

>100_bases
GTTTTCCGTTTCTTTTGTTGCTACTCTCCATTTCTGTCTTTTACTTGCTTTAGTCTCTAGTCTCTAGTCTCTAGTCCCTA
GTCCCTAGTCCTTTATCTCT

Product: Metallo-beta-lactamase family protein, RNA-specific

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHIDHIGRIPWLLAAGFSGSIYC
TEATAELVPLMLEDGLRLQLGLNHKQLHQVLDLVKKRLKPVKYGEWLRLTPRIKNGNRASRSVSHALENYLYLRFNPAGH
ILGSAYLEFKLPNDEIVVFSGDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLAKRVTQSYRRFKKLWGKEAKRRLEVHRHPLAFEQCITIDDYRQH
KALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDERTDVLFAGYQASGTLGREIQTGEKMVQIEQKMVEVRAQIHT
MSGYSAHADQADLLAFIQGIAQKPKEIHLIHGEDDAKQSLLGAMRF

Sequences:

>Translated_446_residues
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHIDHIGRIPWLLAAGFSGSIYC
TEATAELVPLMLEDGLRLQLGLNHKQLHQVLDLVKKRLKPVKYGEWLRLTPRIKNGNRASRSVSHALENYLYLRFNPAGH
ILGSAYLEFKLPNDEIVVFSGDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLAKRVTQSYRRFKKLWGKEAKRRLEVHRHPLAFEQCITIDDYRQH
KALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDERTDVLFAGYQASGTLGREIQTGEKMVQIEQKMVEVRAQIHT
MSGYSAHADQADLLAFIQGIAQKPKEIHLIHGEDDAKQSLLGAMRF
>Mature_446_residues
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHIDHIGRIPWLLAAGFSGSIYC
TEATAELVPLMLEDGLRLQLGLNHKQLHQVLDLVKKRLKPVKYGEWLRLTPRIKNGNRASRSVSHALENYLYLRFNPAGH
ILGSAYLEFKLPNDEIVVFSGDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLAKRVTQSYRRFKKLWGKEAKRRLEVHRHPLAFEQCITIDDYRQH
KALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDERTDVLFAGYQASGTLGREIQTGEKMVQIEQKMVEVRAQIHT
MSGYSAHADQADLLAFIQGIAQKPKEIHLIHGEDDAKQSLLGAMRF

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=443, Percent_Identity=26.86230248307, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI7706427, Length=444, Percent_Identity=26.5765765765766, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32566029, Length=440, Percent_Identity=29.0909090909091, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32564696, Length=460, Percent_Identity=26.304347826087, Blast_Score=164, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6323307, Length=462, Percent_Identity=24.2424242424242, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24648013, Length=455, Percent_Identity=25.9340659340659, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21358523, Length=459, Percent_Identity=27.4509803921569, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49911; Mature: 49911

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHI
CCCEECCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DHIGRIPWLLAAGFSGSIYCTEATAELVPLMLEDGLRLQLGLNHKQLHQVLDLVKKRLKP
HHHCCCHHHEECCCCCCEEEECCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCC
VKYGEWLRLTPRIKNGNRASRSVSHALENYLYLRFNPAGHILGSAYLEFKLPNDEIVVFS
CCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEEECCCCHHCCCEEEEEECCCCCEEEEE
GDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLAKRVTQSYRRFKKLWGKEAKRRLE
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VHRHPLAFEQCITIDDYRQHKALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDER
HHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
TDVLFAGYQASGTLGREIQTGEKMVQIEQKMVEVRAQIHTMSGYSAHADQADLLAFIQGI
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
AQKPKEIHLIHGEDDAKQSLLGAMRF
HCCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MQVIHHGGKDTVTGSCHEFRAAGIALLIDCGLFQGKDARPPEVDFPVKHIDALVLTHAHI
CCCEECCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DHIGRIPWLLAAGFSGSIYCTEATAELVPLMLEDGLRLQLGLNHKQLHQVLDLVKKRLKP
HHHCCCHHHEECCCCCCEEEECCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCC
VKYGEWLRLTPRIKNGNRASRSVSHALENYLYLRFNPAGHILGSAYLEFKLPNDEIVVFS
CCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEEECCCCHHCCCEEEEEECCCCCEEEEE
GDLGPRNTPLLPDPISPPRADYLYIESTYGDKLHESVEERGERLKSIINRSLQDGGTILI
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAFSVGRTQELLFDIEQLIFEHNIGTDIPIILDSPLAKRVTQSYRRFKKLWGKEAKRRLE
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VHRHPLAFEQCITIDDYRQHKALVNRLASTGEPAIVVAASGMCQGGRIMDYLQALLPDER
HHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
TDVLFAGYQASGTLGREIQTGEKMVQIEQKMVEVRAQIHTMSGYSAHADQADLLAFIQGI
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
AQKPKEIHLIHGEDDAKQSLLGAMRF
HCCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA