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The map label for this gene is fumC [H]

Identifier: 255961280

GI number: 255961280

Start: 1000072

End: 1001418

Strand: Direct

Name: fumC [H]

Synonym: Pfl01_0849

Alternate gene names: 255961280

Gene position: 1000072-1001418 (Clockwise)

Preceding gene: 77457075

Following gene: 77457077

Centisome position: 15.53

GC content: 61.32

Gene sequence:

>1347_bases
ATGGGCGAACTGCAGGTGCCGGTGGACGCTCTCTACGGCGCGCAGACCCAGCGTGCAGTGGATAACTTCCCGATCAGCGG
CAAGCCGATGCCAACCCAGTTCATCCGCGCCCTGATTCTGGCGAAAGCGGCCGCCGCCCGCGCCAACGTCGAACTCAACC
AGATCAGCGCCGCGCAAGGCAAAGCCATCAGCGATGCCGCCCAAGGGCTGCTGGAAGGCGACTTCATGCAGCATTTTCCG
GTGGACATTTTCCAGACCGGTTCCGGCACCAGCTCCAACATGAACGCCAACGAGGTGATCGCCACACTGGCCAGTCGTCT
GCTCGAGGAGCCATTAAACGCCAATGATCATGTGAACTGCGGGCAAAGCAGCAACGACATTATTCCAACCACTATTCACG
TCAGCGCCGCGCTGGCCCTGCACGAACAACTGCTGCCGGCGCTGCTGCACCTGGTGCAAGTGATCGAACGCAAGGCCGAG
CAAGTCCATCACCACGTCAAGACTGGCCGCACCCACCTGATGGACGCCATGCCGGTGCGCATGAGCCAGGTGCTCAACGG
TTGGGCGCAGCAGCTCAAAGCCAATATCGGTCACCTGCAGGACTTGCTCCCAAGCCTGCAATCCCTGGCCCAGGGCGGCA
CGGCAGTCGGTACCGGGATCAATGCGCATCCGGAATTTGCTGCGCGTTTCAGCCGCCAATTGAGCCAGTTGACCAACGTC
CAGTTCACGCCAGGCAAGGATCTGTTCGCCCTGATCGGCTCGCAAGACACCGCTGTGGCCGTATCGGGTCAGCTCAAGGC
CACCGCCGTTTCACTGATGAAAATTGCCAACGACCTGCGCTGGATGAACTCCGGCCCGCTCGCCGGCCTCGGTGAGATCG
AACTCGAAGGCCTGCAACCGGGCTCGTCGATCATGCCGGGCAAGGTCAATCCGGTGATTCCGGAAGCCACTGCCATGGTG
GCCGCGCAAGTGATAGGCAACGACTCTGTAATCACCATCGCCGGGCAGTCAGGCAATTTCGAGCTGAACGTGATGCTGCC
GATCATCGCCCAGAACCTGTTGAGCAGCATCGAGTTGCTGGCCAACTCCAGCCGTCTGCTGGCTGACAAGGCCATCGCCA
GCTTCAGGGTCAACGAGTCGCGCCTCAAGGAAGCGCTGTCGCGCAACCCGATTCTGGTCACCGCACTCAACCCGATCATC
GGTTACCAGAAAGCCGCCGAAATCGCCAAGCAGGCCTACAAACAGGGTCGCCCGGTGATCGACGTTGCGCTGGAGCACAC
CGACCTGTCGCGCAGCCAGCTGGAAGAGTTGCTCAATCCCGAGAAGCTCACCGCCGGCGGCGTGTAA

Upstream 100 bases:

>100_bases
ACCTGGCAATTGGCGACCTGCGAGTTGCTTCCCTCGATTCCTCTCATAGAACTGGTGCAAGGATTTTCAGATGACCAAGA
CACGTATTGAGCGCGACAGC

Downstream 100 bases:

>100_bases
GCACCGCAACCGCTTTGGAGGTTCACCATGGAGCACTGGAAACGCACGATCGAACGGGCCAATCGCTGCTTCATGCTTGG
CGAGCTGATCGATGCCCGCG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MGELQVPVDALYGAQTQRAVDNFPISGKPMPTQFIRALILAKAAAARANVELNQISAAQGKAISDAAQGLLEGDFMQHFP
VDIFQTGSGTSSNMNANEVIATLASRLLEEPLNANDHVNCGQSSNDIIPTTIHVSAALALHEQLLPALLHLVQVIERKAE
QVHHHVKTGRTHLMDAMPVRMSQVLNGWAQQLKANIGHLQDLLPSLQSLAQGGTAVGTGINAHPEFAARFSRQLSQLTNV
QFTPGKDLFALIGSQDTAVAVSGQLKATAVSLMKIANDLRWMNSGPLAGLGEIELEGLQPGSSIMPGKVNPVIPEATAMV
AAQVIGNDSVITIAGQSGNFELNVMLPIIAQNLLSSIELLANSSRLLADKAIASFRVNESRLKEALSRNPILVTALNPII
GYQKAAEIAKQAYKQGRPVIDVALEHTDLSRSQLEELLNPEKLTAGGV

Sequences:

>Translated_448_residues
MGELQVPVDALYGAQTQRAVDNFPISGKPMPTQFIRALILAKAAAARANVELNQISAAQGKAISDAAQGLLEGDFMQHFP
VDIFQTGSGTSSNMNANEVIATLASRLLEEPLNANDHVNCGQSSNDIIPTTIHVSAALALHEQLLPALLHLVQVIERKAE
QVHHHVKTGRTHLMDAMPVRMSQVLNGWAQQLKANIGHLQDLLPSLQSLAQGGTAVGTGINAHPEFAARFSRQLSQLTNV
QFTPGKDLFALIGSQDTAVAVSGQLKATAVSLMKIANDLRWMNSGPLAGLGEIELEGLQPGSSIMPGKVNPVIPEATAMV
AAQVIGNDSVITIAGQSGNFELNVMLPIIAQNLLSSIELLANSSRLLADKAIASFRVNESRLKEALSRNPILVTALNPII
GYQKAAEIAKQAYKQGRPVIDVALEHTDLSRSQLEELLNPEKLTAGGV
>Mature_447_residues
GELQVPVDALYGAQTQRAVDNFPISGKPMPTQFIRALILAKAAAARANVELNQISAAQGKAISDAAQGLLEGDFMQHFPV
DIFQTGSGTSSNMNANEVIATLASRLLEEPLNANDHVNCGQSSNDIIPTTIHVSAALALHEQLLPALLHLVQVIERKAEQ
VHHHVKTGRTHLMDAMPVRMSQVLNGWAQQLKANIGHLQDLLPSLQSLAQGGTAVGTGINAHPEFAARFSRQLSQLTNVQ
FTPGKDLFALIGSQDTAVAVSGQLKATAVSLMKIANDLRWMNSGPLAGLGEIELEGLQPGSSIMPGKVNPVIPEATAMVA
AQVIGNDSVITIAGQSGNFELNVMLPIIAQNLLSSIELLANSSRLLADKAIASFRVNESRLKEALSRNPILVTALNPIIG
YQKAAEIAKQAYKQGRPVIDVALEHTDLSRSQLEELLNPEKLTAGGV

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=451, Percent_Identity=42.5720620842572, Blast_Score=354, Evalue=8e-98,
Organism=Escherichia coli, GI1787896, Length=449, Percent_Identity=46.1024498886414, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI87082375, Length=453, Percent_Identity=38.4105960264901, Blast_Score=282, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17553882, Length=451, Percent_Identity=42.5720620842572, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI32565146, Length=322, Percent_Identity=41.9254658385093, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6324993, Length=450, Percent_Identity=42, Blast_Score=355, Evalue=6e-99,
Organism=Drosophila melanogaster, GI78710009, Length=456, Percent_Identity=43.421052631579, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24640179, Length=454, Percent_Identity=44.273127753304, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24640177, Length=454, Percent_Identity=44.273127753304, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24662684, Length=453, Percent_Identity=42.3841059602649, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24583245, Length=453, Percent_Identity=37.3068432671082, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 47665; Mature: 47534

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELQVPVDALYGAQTQRAVDNFPISGKPMPTQFIRALILAKAAAARANVELNQISAAQG
CCCCCCCHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KAISDAAQGLLEGDFMQHFPVDIFQTGSGTSSNMNANEVIATLASRLLEEPLNANDHVNC
CHHHHHHHHHHCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GQSSNDIIPTTIHVSAALALHEQLLPALLHLVQVIERKAEQVHHHVKTGRTHLMDAMPVR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
MSQVLNGWAQQLKANIGHLQDLLPSLQSLAQGGTAVGTGINAHPEFAARFSRQLSQLTNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHCC
QFTPGKDLFALIGSQDTAVAVSGQLKATAVSLMKIANDLRWMNSGPLAGLGEIELEGLQP
CCCCCCCHHEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
GSSIMPGKVNPVIPEATAMVAAQVIGNDSVITIAGQSGNFELNVMLPIIAQNLLSSIELL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHH
ANSSRLLADKAIASFRVNESRLKEALSRNPILVTALNPIIGYQKAAEIAKQAYKQGRPVI
HCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEE
DVALEHTDLSRSQLEELLNPEKLTAGGV
EEEECCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GELQVPVDALYGAQTQRAVDNFPISGKPMPTQFIRALILAKAAAARANVELNQISAAQG
CCCCCCHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KAISDAAQGLLEGDFMQHFPVDIFQTGSGTSSNMNANEVIATLASRLLEEPLNANDHVNC
CHHHHHHHHHHCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GQSSNDIIPTTIHVSAALALHEQLLPALLHLVQVIERKAEQVHHHVKTGRTHLMDAMPVR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
MSQVLNGWAQQLKANIGHLQDLLPSLQSLAQGGTAVGTGINAHPEFAARFSRQLSQLTNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHCC
QFTPGKDLFALIGSQDTAVAVSGQLKATAVSLMKIANDLRWMNSGPLAGLGEIELEGLQP
CCCCCCCHHEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
GSSIMPGKVNPVIPEATAMVAAQVIGNDSVITIAGQSGNFELNVMLPIIAQNLLSSIELL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHH
ANSSRLLADKAIASFRVNESRLKEALSRNPILVTALNPIIGYQKAAEIAKQAYKQGRPVI
HCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEE
DVALEHTDLSRSQLEELLNPEKLTAGGV
EEEECCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8806672; 10984043 [H]