Click here to switch to the map view.

The map label for this gene is dhbC

Identifier: 255767733

GI number: 255767733

Start: 3290289

End: 3291485

Strand: Reverse

Name: dhbC

Synonym: BSU31990

Alternate gene names: 255767733

Gene position: 3291485-3290289 (Counterclockwise)

Preceding gene: 255767734

Following gene: 16080251

Centisome position: 78.08

GC content: 53.47

Gene sequence:

>1197_bases
ATGTTGGATCAAAACGTTATAACAGAAACAAAAGCGGAGCATTTGCTTCATGAATATCAGCCGGGCGCCTTTTTCTTAGC
GTCTCCTCATCGTGTACTGTTAGCGAAAGGCATATGTGAAATTGTACCGGAGGCAGACGGGCAAAACCAAATGGAAACCC
TTTCTGGCCGAATTGCAGAGGCGTTACGTCAGGCAAAACAATCAGGGCAAAGCCGGCCGCTTGTTGTCGGGGCCGTTCCT
TTTGATCAAGTAAAAGCAGCGCGGCTCGTTGTACCTGAAGAAGTGCGCTGGTCAGGACCGCTTCAATTTGATCATGAGGA
AAAGGAACAGCAGGCTGGGCATACATACCACATAAAGCCTGTTCCTGAACCTGAGGATTATAAAAATGGTGTTGAACAAG
GGCTGGCACGCATTGCCGATGGAACACTCAGCAAAATCGTCCTGTCCAGATCGCTGCATTTGACATCGCCTGAACCGATT
CAGACGGATGAATTGCTTCGCCATCTGGCTCAGCATAACTCGCATGGCTACACGTTTGCCGCAGACGTGTCCAGTCAGGA
GGAAACGTCTCCCCGCAGAACATTGCTCGGAGCAAGTCCGGAGCTTCTCGTTTCAAGGATGGGAACACAGGTCGTTTCCA
ACCCATTAGCCGGCTCAAGACCGCGCAGTAATGATCCTGTTGAAGACCAGCGCCGGGCAGCTGAATTGCTTTCTTCCGCA
AAGGATCTTCATGAGCACGCGGTTGTCGCTGACGCGGTTGCGGCAGCGCTGAGACCTTTCTGCCGGACGCTGGAGGTTCC
GGAGAAGCCTTCACTGATCAAAACGGAAACGATGTGGCACCTGTCCAGCGTGATTAAGGGAGAGCTTTCCGACCCGTCTG
TAACCGCACTTGAATTGGCGGCGGCGCTCCACCCGACGCCAGCCGTCTGCGGAACACCGACTGATCTTGCAAGAGAAGCG
ATTCTCAGCATTGAACCATTTGACCGCGGTTTCTTTACCGGCATGGTCGGATGGTGTGACGATGCCGGTGACGGAGAATG
GATCGTGACCATCCGTTGTGCAGAAGCAGAAGAACGCTCACTCCGCCTGTATGCTGGAGCTGGTGTTGTGGCCGGTTCAA
AGCCTGAGGACGAGCTTCAGGAGACGTCCGCAAAGTTTCGGACAATGCTGCGGGCAATGGGCGTGGATCACATATGA

Upstream 100 bases:

>100_bases
TTGGTTTCTGGCCAGGCAGGGCATATTACGATGCATAATTTATGCGTAGATGGCGGCGCGACCTTAGGCGTGTAACTGAA
TTTAAAGGAGGTTCATGAGA

Downstream 100 bases:

>100_bases
ACAGAATGAATTGCTGGAGGGATACAACATGCTGAAAGGATTTACGCCTTGGCCTGATGAGTTAGCTGAGACCTATCGAA
AGAACGGCTGCTGGGCCGGT

Product: isochorismate synthase DhbC

Products: NA

Alternate protein names: Isochorismate mutase

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPEADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVP
FDQVKAARLVVPEEVRWSGPLQFDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI
QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAGSRPRSNDPVEDQRRAAELLSSA
KDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTETMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREA
ILSIEPFDRGFFTGMVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRAMGVDHI

Sequences:

>Translated_398_residues
MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPEADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVP
FDQVKAARLVVPEEVRWSGPLQFDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI
QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAGSRPRSNDPVEDQRRAAELLSSA
KDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTETMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREA
ILSIEPFDRGFFTGMVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRAMGVDHI
>Mature_398_residues
MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPEADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVP
FDQVKAARLVVPEEVRWSGPLQFDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI
QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAGSRPRSNDPVEDQRRAAELLSSA
KDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTETMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREA
ILSIEPFDRGFFTGMVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRAMGVDHI

Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family

Homologues:

Organism=Escherichia coli, GI1786809, Length=385, Percent_Identity=37.4025974025974, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082077, Length=274, Percent_Identity=30.2919708029197, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787518, Length=270, Percent_Identity=30.3703703703704, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788114, Length=271, Percent_Identity=26.5682656826568, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=266, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHBC_BACSU (P45744)

Other databases:

- EMBL:   U26444
- EMBL:   AL009126
- PIR:   C69615
- RefSeq:   NP_391079.2
- ProteinModelPortal:   P45744
- SMR:   P45744
- PhosSite:   P45744
- EnsemblBacteria:   EBBACT00000000822
- GeneID:   937162
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU31990
- NMPDR:   fig|224308.1.peg.3205
- GenoList:   BSU31990
- GeneTree:   EBGT00050000001425
- HOGENOM:   HBG405459
- PhylomeDB:   P45744
- ProtClustDB:   PRK06923
- BioCyc:   BSUB:BSU31990-MONOMER
- BioCyc:   MetaCyc:MONOMER-13807
- BRENDA:   5.4.4.2
- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561
- Gene3D:   G3DSA:3.60.120.10
- PANTHER:   PTHR11236:SF3
- PANTHER:   PTHR11236
- TIGRFAMs:   TIGR00543

Pfam domain/function: PF00425 Chorismate_bind; SSF56322 TRPE_1_chor_bd

EC number: =5.4.4.2

Molecular weight: Translated: 43437; Mature: 43437

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPEADGQNQMETLSGRIAE
CCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQFDHEEKEQQAGHTYHIKP
HHHHHHHCCCCCCEEEECCCHHHHHHHHEECCHHHCCCCCCCCCCHHHHHHCCCEEEECC
VPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPIQTDELLRHLAQHNSHGYTFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
ADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAGSRPRSNDPVEDQRRAAELLSSA
ECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
KDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTETMWHLSSVIKGELSDPSVTALELA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
AALHPTPAVCGTPTDLAREAILSIEPFDRGFFTGMVGWCDDAGDGEWIVTIRCAEAEERS
HHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCC
LRLYAGAGVVAGSKPEDELQETSAKFRTMLRAMGVDHI
EEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPEADGQNQMETLSGRIAE
CCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQFDHEEKEQQAGHTYHIKP
HHHHHHHCCCCCCEEEECCCHHHHHHHHEECCHHHCCCCCCCCCCHHHHHHCCCEEEECC
VPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPIQTDELLRHLAQHNSHGYTFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
ADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAGSRPRSNDPVEDQRRAAELLSSA
ECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
KDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTETMWHLSSVIKGELSDPSVTALELA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
AALHPTPAVCGTPTDLAREAILSIEPFDRGFFTGMVGWCDDAGDGEWIVTIRCAEAEERS
HHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCC
LRLYAGAGVVAGSKPEDELQETSAKFRTMLRAMGVDHI
EEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550523; 9384377