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The map label for this gene is comC

Identifier: 255767643

GI number: 255767643

Start: 2864426

End: 2865172

Strand: Reverse

Name: comC

Synonym: BSU28070

Alternate gene names: 255767643

Gene position: 2865172-2864426 (Counterclockwise)

Preceding gene: 16079860

Following gene: 16079858

Centisome position: 67.97

GC content: 45.25

Gene sequence:

>747_bases
ATGCTATCCATTCTTTTTATCTTCGGGCTTATCCTTGGTTCTTTTTACTATACGGCCGGGTGCCGTATCCCCTTACATCT
ATCTATTATTGCGCCCCGTTCATCATGCCCGTTTTGCCGGCGAACATTAACTCCTGCAGAATTAATTCCCATCCTGTCAT
TCCTATTTCAAAAAGGTAAATGTAAAAGCTGCGGGCATAGGATTTCTTTTATGTATCCCGCAGCAGAGCTTGTGACAGCG
TGTTTATTTGCCGCCGCAGGAATACGCTTTGGCATATCGCTGGAACTGTTTCCCGCTGTGGTGTTTATCTCTCTTCTCAT
TATTGTTGCAGTGACAGATATTCATTTTATGCTGATTCCAAATCGAATATTGATTTTCTTTCTTCCCTTTTTGGCGGCCG
CGAGATTGATTTCTCCGCTTGATTCCTGGTATGCAGGCCTGTTAGGTGCGGCAGCCGGATTTTTGTTTCTGGCTGTAATT
GCCGCAATCACCCATGGGGGAGTAGGGGGAGGAGATATTAAATTATTTGCGGTGATTGGCTTTGTGCTTGGTGTGAAAAT
GCTGGCAGCTGCCTTTTTCTTTTCAGTTTTGATAGGTGCATTATATGGAGCGGCAGCTGTTCTGACTGGTAGACTCGCTA
AAAGGCAGCCGCTTCCCTTCGCCCCCGCTATAGCCGCAGGGAGCATTTTAGCCTATTTATACGGTGACTCTATCATTTCT
TTTTATATCAAAATGGCATTGGGCTGA

Upstream 100 bases:

>100_bases
GTTTTTTTCATGTGTAAAATTGAATATTCCCAATTGGAGCTCAGGATGTCCATTTTGCTACAATCCATACCAGAACTCAA
TGAGTAAAGGTGTGTTGTCT

Downstream 100 bases:

>100_bases
CTGCTGAAAAATTTGACGAACGTTTTTTGGACAAGGCGACAAAAGTCTTGTTCTTTTTTTCTTTGCCTGTGCTAAAGTGT
GTAGCATGAAAAGCCGACAA

Product: membrane protease and transmethylase

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLTPAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTA
CLFAAAGIRFGISLELFPAVVFISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI
AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPLPFAPAIAAGSILAYLYGDSIIS
FYIKMALG

Sequences:

>Translated_248_residues
MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLTPAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTA
CLFAAAGIRFGISLELFPAVVFISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI
AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPLPFAPAIAAGSILAYLYGDSIIS
FYIKMALG
>Mature_248_residues
MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLTPAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTA
CLFAAAGIRFGISLELFPAVVFISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI
AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPLPFAPAIAAGSILAYLYGDSIIS
FYIKMALG

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family

Homologues:

Organism=Escherichia coli, GI87082194, Length=250, Percent_Identity=30.8, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEP4_BACSU (P15378)

Other databases:

- EMBL:   M30805
- EMBL:   AL009126
- EMBL:   L04520
- EMBL:   L04519
- PIR:   A33490
- RefSeq:   NP_390685.2
- EnsemblBacteria:   EBBACT00000000396
- GeneID:   936586
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU28070
- NMPDR:   fig|224308.1.peg.2810
- GenoList:   BSU28070
- GeneTree:   EBGT00050000002198
- HOGENOM:   HBG710101
- PhylomeDB:   P15378
- ProtClustDB:   CLSK2484790
- BioCyc:   BSUB:BSU28070-MONOMER
- BRENDA:   3.4.23.43
- InterPro:   IPR010627
- InterPro:   IPR000045

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24

EC number: =3.4.23.43

Molecular weight: Translated: 26435; Mature: 26435

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x110116e8)-; HASH(0x1164e570)-; HASH(0x107f69f4)-; HASH(0x1131eb28)-; HASH(0x10fc5354)-; HASH(0x115b2980)-; HASH(0x1061cedc)-;

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLTPAELIPILSFLFQKGK
CHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHCCCC
CKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVFISLLIIVAVTDIHFMLIP
CHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVIAAITHGGVGGGDIKLFAVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPLPFAPAIAAGSILAYLYGDSIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FYIKMALG
HHHHHHCH
>Mature Secondary Structure
MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLTPAELIPILSFLFQKGK
CHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHCCCC
CKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVFISLLIIVAVTDIHFMLIP
CHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVIAAITHGGVGGGDIKLFAVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPLPFAPAIAAGSILAYLYGDSIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FYIKMALG
HHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299