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The map label for this gene is uvrX

Identifier: 255767474

GI number: 255767474

Start: 2270407

End: 2271657

Strand: Reverse

Name: uvrX

Synonym: BSU21500

Alternate gene names: 255767474

Gene position: 2271657-2270407 (Counterclockwise)

Preceding gene: 16079210

Following gene: 16079208

Centisome position: 53.89

GC content: 39.41

Gene sequence:

>1251_bases
ATGATTGATTACTCACAATTTCCACGTAAGAATATACTTTGTGTCGATATGAAATCCTTTTATGCTTCTGTATCGGCTGT
AACAATGGGGCTTAACCCTTTAACATGCTATCTTGCTGTTGTAGGGAATACGGATAGACAGGGAAGTGTAGTGTTAGCTG
CATCTCCTGCACTTAAAAAAGATTTTGGAATCAAAACAGGATCGAGACTATTTGAGATACCTGAAGATCCAAGAATACAC
ATTGTAAATCCACAAATGAAGCTTTTCATCAGAGTTTCAACTGAAATTACAAAGCTGTTTTACAGATTTGTTCCTGAGAA
ATGTGTCCATACGTATTCAATTGATGAATCTTTTTTAGATGCAGGAAAAGAAGATCCTGAAGAAATGGCCAAAGCAATCC
AAAGCAGCATGTGGAGAGAATTTGGTTTGATGTGCACAGTTGGTATTGGAGACAATATGCTACTCAGTAAGCTTGCACTT
GACCTGGAGAGTAAGAAAACAAAGAGTGGCATTGCACGTTGGAGATATGAAGATGTACCAAATAAACTCTGGAAGGTTCG
CCCTTTGTCTAAAATGTGGGGGATAGGAGGGAGGATGGAAAGAAACCTAAATCGGATGGGAATATCGACTATAGGTCAGT
TAGCCAAATTTCCTTTAGAGCTGCTTGAAAAGAAGTTCGGAATAATGGGAAACCAGTTGTACTACCATGCTCACGGAATT
GATTTATCAGAAATAGGTGCTCCGTTGATGCAAGGTCAGATTAGTTTCGGTAAGAGTCAGATTTTACTGAGGGATTACAC
AAGGAGTGAAGAGATTAAGGCGGTTCTTCTGGAGATTTGTGAAGAAGTCGCAAGAAGGGCACGTACACATAATAAAGTTG
GTCGAACAATCAGTCTGGGAATTGGGTACAGTAAGGATGAGCTTGGTGGTGGTTTTCATCGTTCCAAAACAATTGATCTT
CCTACAAGTATCACGATGGATATTTATAGATGCTGCTTGATGCTTTTTAATAAGTTTTACTCGGGTAAGACTGTGAGAAG
TGTCTCAGTCACGTTATCGAATATTGAGGATGATGTTAATCAGCAGCTGAGTTTATTTGAAGTGGATAATGAAAAGAGAA
GGAAACTCGGTTTTGTAATGGATGGGATTAGAAGTAAATACGGCTCTAAAGCGATTCTGAGAGCAGTTTCTTATACACCA
GCAGGAACTGCACTTCAACGAGCTGGATTAACAGGTGGGCATAAGAGTTAA

Upstream 100 bases:

>100_bases
GTCCATTACATAAATTTTGAACAACAAAAGCTTCACGTAAAAGACCAGAATGACAATACAGTTTATATCAACATGAATAA
CATCATAGGAGTTACATACA

Downstream 100 bases:

>100_bases
GATAAATTTAAACTTATATAACACATCGCTTAAAGTTTTTTTGTTTTAAAAACTTAAAAAACATGGTAAAATTATATAAA
AACATAAGAAAGAGTGATTA

Product: lesion bypass phage DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MIDYSQFPRKNILCVDMKSFYASVSAVTMGLNPLTCYLAVVGNTDRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIH
IVNPQMKLFIRVSTEITKLFYRFVPEKCVHTYSIDESFLDAGKEDPEEMAKAIQSSMWREFGLMCTVGIGDNMLLSKLAL
DLESKKTKSGIARWRYEDVPNKLWKVRPLSKMWGIGGRMERNLNRMGISTIGQLAKFPLELLEKKFGIMGNQLYYHAHGI
DLSEIGAPLMQGQISFGKSQILLRDYTRSEEIKAVLLEICEEVARRARTHNKVGRTISLGIGYSKDELGGGFHRSKTIDL
PTSITMDIYRCCLMLFNKFYSGKTVRSVSVTLSNIEDDVNQQLSLFEVDNEKRRKLGFVMDGIRSKYGSKAILRAVSYTP
AGTALQRAGLTGGHKS

Sequences:

>Translated_416_residues
MIDYSQFPRKNILCVDMKSFYASVSAVTMGLNPLTCYLAVVGNTDRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIH
IVNPQMKLFIRVSTEITKLFYRFVPEKCVHTYSIDESFLDAGKEDPEEMAKAIQSSMWREFGLMCTVGIGDNMLLSKLAL
DLESKKTKSGIARWRYEDVPNKLWKVRPLSKMWGIGGRMERNLNRMGISTIGQLAKFPLELLEKKFGIMGNQLYYHAHGI
DLSEIGAPLMQGQISFGKSQILLRDYTRSEEIKAVLLEICEEVARRARTHNKVGRTISLGIGYSKDELGGGFHRSKTIDL
PTSITMDIYRCCLMLFNKFYSGKTVRSVSVTLSNIEDDVNQQLSLFEVDNEKRRKLGFVMDGIRSKYGSKAILRAVSYTP
AGTALQRAGLTGGHKS
>Mature_416_residues
MIDYSQFPRKNILCVDMKSFYASVSAVTMGLNPLTCYLAVVGNTDRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIH
IVNPQMKLFIRVSTEITKLFYRFVPEKCVHTYSIDESFLDAGKEDPEEMAKAIQSSMWREFGLMCTVGIGDNMLLSKLAL
DLESKKTKSGIARWRYEDVPNKLWKVRPLSKMWGIGGRMERNLNRMGISTIGQLAKFPLELLEKKFGIMGNQLYYHAHGI
DLSEIGAPLMQGQISFGKSQILLRDYTRSEEIKAVLLEICEEVARRARTHNKVGRTISLGIGYSKDELGGGFHRSKTIDL
PTSITMDIYRCCLMLFNKFYSGKTVRSVSVTLSNIEDDVNQQLSLFEVDNEKRRKLGFVMDGIRSKYGSKAILRAVSYTP
AGTALQRAGLTGGHKS

Specific function: Poorly Processive, Error-Prone DNA Polymerase Involved In Untargeted Mutagenesis. Copies Undamaged DNA At Stalled Replication Forks, Which Arise In Vivo From Mismatched Or Misaligned Primer Ends. These Misaligned Primers Can Be Extended By Poliv. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI7706681, Length=204, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI84043967, Length=204, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786425, Length=285, Percent_Identity=25.6140350877193, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787432, Length=401, Percent_Identity=26.6832917705736, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRX_BACSU (O31990)

Other databases:

- EMBL:   AF014938
- EMBL:   AL009126
- RefSeq:   NP_390033.2
- ProteinModelPortal:   O31990
- EnsemblBacteria:   EBBACT00000001772
- GeneID:   939122
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU21500
- GenoList:   BSU21500
- GeneTree:   EBGT00050000001510
- HOGENOM:   HBG734504
- ProtClustDB:   CLSK2765378
- BioCyc:   BSUB:BSU21500-MONOMER
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: 2.7.7.7 [C]

Molecular weight: Translated: 46716; Mature: 46716

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYSQFPRKNILCVDMKSFYASVSAVTMGLNPLTCYLAVVGNTDRQGSVVLAASPALKK
CCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCHHH
DFGIKTGSRLFEIPEDPRIHIVNPQMKLFIRVSTEITKLFYRFVPEKCVHTYSIDESFLD
HCCCCCCCCEEECCCCCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AGKEDPEEMAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIARWRYEDVP
CCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NKLWKVRPLSKMWGIGGRMERNLNRMGISTIGQLAKFPLELLEKKFGIMGNQLYYHAHGI
HHHEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
DLSEIGAPLMQGQISFGKSQILLRDYTRSEEIKAVLLEICEEVARRARTHNKVGRTISLG
CHHHHCCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
IGYSKDELGGGFHRSKTIDLPTSITMDIYRCCLMLFNKFYSGKTVRSVSVTLSNIEDDVN
CCCCHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHH
QQLSLFEVDNEKRRKLGFVMDGIRSKYGSKAILRAVSYTPAGTALQRAGLTGGHKS
CCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MIDYSQFPRKNILCVDMKSFYASVSAVTMGLNPLTCYLAVVGNTDRQGSVVLAASPALKK
CCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCHHH
DFGIKTGSRLFEIPEDPRIHIVNPQMKLFIRVSTEITKLFYRFVPEKCVHTYSIDESFLD
HCCCCCCCCEEECCCCCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AGKEDPEEMAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIARWRYEDVP
CCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NKLWKVRPLSKMWGIGGRMERNLNRMGISTIGQLAKFPLELLEKKFGIMGNQLYYHAHGI
HHHEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
DLSEIGAPLMQGQISFGKSQILLRDYTRSEEIKAVLLEICEEVARRARTHNKVGRTISLG
CHHHHCCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
IGYSKDELGGGFHRSKTIDLPTSITMDIYRCCLMLFNKFYSGKTVRSVSVTLSNIEDDVN
CCCCHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHH
QQLSLFEVDNEKRRKLGFVMDGIRSKYGSKAILRAVSYTPAGTALQRAGLTGGHKS
CCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9722542; 9384377