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The map label for this gene is pksS

Identifier: 255767401

GI number: 255767401

Start: 1858566

End: 1859783

Strand: Reverse

Name: pksS

Synonym: BSU17230

Alternate gene names: 255767401

Gene position: 1859783-1858566 (Counterclockwise)

Preceding gene: 255767402

Following gene: 16078769

Centisome position: 44.12

GC content: 41.05

Gene sequence:

>1218_bases
ATGGAAAAATTGATGTTTCATCCGCATGGTAAAGAGTTTCATCACAATCCTTTTTCAGTTTTAGGACGATTTAGAGAGGA
AGAGCCCATTCACCGATTTGAATTAAAACGGTTCGGAGCCACATATCCGGCCTGGTTAATTACCCGATACGATGATTGTA
TGGCCTTTTTAAAAGACAATCGAATTACAAGAGACGTAAAAAATGTGATGAACCAAGAACAAATCAAAATGCTCAACGTT
AGTGAAGATATCGATTTTGTATCCGATCATATGCTGGCAAAAGACACACCTGACCATACCCGCCTGAGATCACTTGTTCA
TCAAGCATTTACTCCCCGAACCATTGAAAATCTGCGCGGCAGCATTGAACAAATTGCTGAACAGCTTTTAGATGAAATGG
AAAAAGAAAATAAAGCGGATATCATGAAATCCTTCGCTTCCCCTTTGCCTTTTATTGTTATATCTGAATTGATGGGAATC
CCAAAAGAAGATCGGTCACAGTTTCAAATCTGGACCAATGCGATGGTTGATACCTCTGAAGGTAATAGAGAGCTGACAAA
TCAGGCCCTTCGTGAATTTAAAGATTATATCGCTAAGCTGATCCATGACAGAAGAATAAAGCCAAAAGACGATTTAATCA
GCAAACTTGTGCATGCTGAGGAAAACGGCAGCAAGTTAAGCGAAAAAGAGCTCTATTCGATGCTGTTCTTGCTCGTTGTA
GCCGGCCTTGAAACAACTGTTAACTTACTCGGCTCAGGCACCCTCGCATTGCTGCAGCACAAGAAGGAATGTGAGAAGCT
CAAGCAGCAGCCTGAAATGATCGCTACAGCGGTTGAAGAATTGCTGCGATACACCTCACCTGTCGTTATGATGGCAAATC
GGTGGGCCATCGAAGACTTTACATATAAGGGGCATTCGATCAAAAGAGGAGACATGATTTTTATAGGCATCGGATCTGCC
AATCGCGACCCGAATTTTTTTGAGAACCCCGAAATATTAAATATAAATCGGTCGCCTAATAGACATATTTCTTTTGGTTT
TGGCATTCATTTCTGCTTAGGAGCGCCTCTTGCCAGGCTGGAAGGCCACATTGCATTTAAAGCACTTTTGAAGAGATTTC
CTGATATTGAACTTGCGGTTGCACCTGATGACATTCAATGGAGAAAAAATGTCTTTTTAAGAGGATTAGAAAGTCTCCCT
GTTTCACTTTCAAAATAA

Upstream 100 bases:

>100_bases
AGTTTTAGAGACAGGATTACATTTCAAATCATTCTGTTTTTTGTAAACTAATTCAGCAATTTGATTCATCTATTTACCCT
ATTAGGCGAGGAGAATGCAA

Downstream 100 bases:

>100_bases
CATTCAAAACGCCCCCTTTTAAAAGAGGGGGCGTTTGTGTTTTCTCAGCGCTTCACCAATTCATCTGTTTCTTTTTCTTC
CCTCGCTTCATGTTTCTTCC

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNV
SEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI
PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVV
AGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSA
NRDPNFFENPEILNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLP
VSLSK

Sequences:

>Translated_405_residues
MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNV
SEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI
PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVV
AGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSA
NRDPNFFENPEILNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLP
VSLSK
>Mature_405_residues
MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNV
SEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI
PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVV
AGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSA
NRDPNFFENPEILNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLP
VSLSK

Specific function: Involved in the metabolism of the antibiotic polyketide bacillaene which is involved in secondary metabolism. The substrate is dihydrobacillaene

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family

Homologues:

Organism=Homo sapiens, GI15147328, Length=241, Percent_Identity=24.4813278008299, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI15147330, Length=241, Percent_Identity=24.4813278008299, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PKSS_BACSU (O31785)

Other databases:

- EMBL:   AL009126
- RefSeq:   NP_389605.2
- HSSP:   Q00441
- ProteinModelPortal:   O31785
- SMR:   O31785
- EnsemblBacteria:   EBBACT00000001816
- GeneID:   940046
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU17230
- GenoList:   BSU17230
- GeneTree:   EBGT00050000001046
- HOGENOM:   HBG695262
- ProtClustDB:   CLSK887326
- BioCyc:   BSUB:BSU17230-MONOMER
- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972
- Gene3D:   G3DSA:1.10.630.10
- PANTHER:   PTHR19383
- PRINTS:   PR00359

Pfam domain/function: PF00067 p450; SSF48264 Cytochrome_P450

EC number: NA

Molecular weight: Translated: 46730; Mature: 46730

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xea25c08)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDN
CCCCEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
RITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRG
CHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGIPKEDRSQFQIWTNAMVDTSE
HHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHEEECCC
GNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEECCC
TYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSPNRHISFGFGIHFCLGAPLARL
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEECCHHHHHHCCCHHHH
EGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLPVSLSK
HHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDN
CCCCEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
RITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRG
CHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGIPKEDRSQFQIWTNAMVDTSE
HHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHEEECCC
GNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEECCC
TYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSPNRHISFGFGIHFCLGAPLARL
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEECCHHHHHHCCCHHHH
EGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLPVSLSK
HHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377