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The map label for this gene is pgsA

Identifier: 255767387

GI number: 255767387

Start: 1762623

End: 1763204

Strand: Direct

Name: pgsA

Synonym: BSU16920

Alternate gene names: 255767387

Gene position: 1762623-1763204 (Clockwise)

Preceding gene: 255767386

Following gene: 255767388

Centisome position: 41.81

GC content: 44.16

Gene sequence:

>582_bases
ATGTTTAACTTACCAAATAAAATCACACTAGCTAGAATCGCATTAATCCCAATCTTCATGATTATCATGCTGGCGCCGTT
TGACTGGGGCAGGCTCGAAGTTGGAGACGAATCCATCCCGGTCGCACATTTGGCGGGGGCCATTCTATTTATTATTGCAT
CTACAACAGACTGGGTGGACGGGTATTATGCCCGAAAATTAAATCTCGTAACAAACTTCGGGAAATTTCTTGATCCGCTT
GCGGACAAACTGCTCGTATCCGCAGCGTTAATTATCCTTGTTCAATTTGATCTCGCTCCAGCTTGGATGGTCATTGTGAT
TATCAGCAGGGAGTTTGCCGTGACAGGTTTAAGGCTTGTCTTAGCCGGAACAGGAGAAGTCGTAGCTGCTAACATGCTTG
GTAAAATCAAAACCTGGGCACAGATTATTGCGGTATCTGCATTGCTTCTTCATAATCTTCCATTTGAACTTGTGTCATTC
CCGTTTGCAGACTTGGCGCTGTGGGTAGCCGTCTTCTTTACTGTCGTCTCAGGCTGGGAATATTTCTCTAAAAATTGGGA
AGCGTTAAAAACATCTAACTAA

Upstream 100 bases:

>100_bases
ATGGCACAAACCATAAAGATTGTAAATAAAAAGGAAGAAAAGTCATCTTAATTACCAGATGACTTTTCTTCACGTCCGAG
TATGAAATTGGAGGGGCTTT

Downstream 100 bases:

>100_bases
GAAAGAAGGACTTCGTCATGGAATTTCCAAAAAAAGCAGAAATAATTGCAGTCGGTTCAGAGTTGCTGCTTGGTCAAATC
GCCAATACAAATGCTCAATT

Product: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHLAGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPL
ADKLLVSAALIILVQFDLAPAWMVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF
PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN

Sequences:

>Translated_193_residues
MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHLAGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPL
ADKLLVSAALIILVQFDLAPAWMVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF
PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN
>Mature_193_residues
MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHLAGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPL
ADKLLVSAALIILVQFDLAPAWMVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF
PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

Homologues:

Organism=Escherichia coli, GI1788220, Length=154, Percent_Identity=37.012987012987, Blast_Score=97, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGSA_BACSU (P46322)

Other databases:

- EMBL:   D50064
- EMBL:   U87792
- EMBL:   AL009126
- PIR:   E69675
- RefSeq:   NP_389574.2
- EnsemblBacteria:   EBBACT00000002351
- GeneID:   939675
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU16920
- NMPDR:   fig|224308.1.peg.1695
- GenoList:   BSU16920
- GeneTree:   EBGT00050000002310
- HOGENOM:   HBG686655
- ProtClustDB:   CLSK887317
- BioCyc:   BSUB:BSU16920-MONOMER
- BRENDA:   2.7.8.5
- InterPro:   IPR000462
- InterPro:   IPR004570
- PIRSF:   PIRSF000847
- TIGRFAMs:   TIGR00560

Pfam domain/function: PF01066 CDP-OH_P_transf

EC number: =2.7.8.5

Molecular weight: Translated: 21339; Mature: 21339

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe962304)-; HASH(0xee00064)-; HASH(0xec1ca94)-; HASH(0xf511bfc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHLAGAILFIIASTTDWVD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHH
GYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAWMVIVIISREFAVTGLRLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHE
LAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSFPFADLALWVAVFFTVVSGWE
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
YFSKNWEALKTSN
HHHCCCCHHCCCH
>Mature Secondary Structure
MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHLAGAILFIIASTTDWVD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHH
GYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAWMVIVIISREFAVTGLRLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHE
LAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSFPFADLALWVAVFFTVVSGWE
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
YFSKNWEALKTSN
HHHCCCCHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377