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The map label for this gene is obgE [H]

Identifier: 239618481

GI number: 239618481

Start: 2254660

End: 2255973

Strand: Direct

Name: obgE [H]

Synonym: Kole_2122

Alternate gene names: 239618481

Gene position: 2254660-2255973 (Clockwise)

Preceding gene: 239618465

Following gene: 239618482

Centisome position: 97.94

GC content: 44.22

Gene sequence:

>1314_bases
ATGATACCCACAGGCGAGAGTTTAGTAGACACGGGAAAAATATTTGTAAAAGCCGGAAAAGGCGGCGATGGTGCTGTTTC
TTTCCGACGTGAGAAGTACATACCTTTCGGCGGCCCAGATGGTGGCGATGGTGGCAACGGTGGTAATGTTTTCATTCGAG
CGACCACAAGCAAGAATACATTGCTTGAATTCCAGAGCAAAAAGAAGTTCGAGGCAGAAGACGGTGAAAACGGGTCAGGA
GGAAAAAAATACGGGAAAAAGGGAAAAGATGTCATAATCGAAGTTCCCGTAGGAACACTTGTTTACGACGCGGAAACCGG
AGAATTACTCGCCGATCTATCTTCACCGGGAGACATTGTTTGTGTTGCAAGAGGCGGCAAAGGTGGACGTGGAAATGTTC
ACTTCGCAACCTCAGTTAATCAAGCACCAAGAGTAGCAGAAGCAGGAGAACCGGGCGAAGAACGCAAAATATATCTAGAG
TTAAAACTTCTGGCAGACGTTGGCTTGATAGGTTTTCCAAATACGGGAAAATCCACGATCATTTCAAAGATCTCCAATTC
GAAGCCAAAGATTGCTAACTACCATTTCACGACCCTTGTGCCAAACCTCGGGGTTGTGAAACTGTCTCCAGAACACGGGT
TCATAGTCGCTGATGTTCCTGGACTCGTGAAAGGTGCCCACAAAGGAGCTGGCCTCGGGCACAATTTTTTGAAACATGTG
GAGCGTTGCTACCTTCTCGTCCATGTGCTGGATATAGCAGAAACTGAAGATAGAGACTTCATTCAGGATTATTATGATAT
CCGCAAGGAACTGGAACTTCACAATGAGGAGCTGGCCAAAAAACCGGAAATTGTTGTCGGAAACAAAATCGATGTCCTCA
GCGATGAAGAGATTGAAAAACGCGTAAAGCGGTTTTATGATCAAACCGGGAAAAAAATTCTACCTATATCGGCTATTCAG
GGCAGAAATATAGACAAACTAAAATGGGAGATGTGGGAAAAGATAAAAACACAAAAAACATTTCTTAAAAAAACGGGTGT
CGCTTCACAGAAAAAAACGCCAAAAGTAAAACCGGTATCGCGTGAAGCTCCGGATCCTTCCGAATTCTTCATACACAAAG
ATTCAAAAGGAAGGTATGTTGTCGAAGGACCTGCGGTTGATTACTACGCAGAAAAATTCAAGGTGGAAAATCAAGATAAA
TTCTTACTGGATAAGCTCGAAGCCGGAGGTCTTTCGGAGAGACTGAGAAAGATGGGAGCTCAGGAAGGTGATATCGTTGT
GATCAGAGGGCGTGAATATGAATACATGGAATAA

Upstream 100 bases:

>100_bases
AAAGGAGTCAAACCCTATGTTCACTATTCTTTCCATCATCACTTCCTCCTTTTGCTTAACAGTGTTATTATAACATATGA
GAAGAATGCGGAGGTGTACC

Downstream 100 bases:

>100_bases
AAGATACGGCATCTTTGGGGGATCATTCGATCCGATACACGTTGGACACGTCATTATTGCGACGAGGGCCATTGAAGCCC
TCTCGCTTGATAGATTATAC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MIPTGESLVDTGKIFVKAGKGGDGAVSFRREKYIPFGGPDGGDGGNGGNVFIRATTSKNTLLEFQSKKKFEAEDGENGSG
GKKYGKKGKDVIIEVPVGTLVYDAETGELLADLSSPGDIVCVARGGKGGRGNVHFATSVNQAPRVAEAGEPGEERKIYLE
LKLLADVGLIGFPNTGKSTIISKISNSKPKIANYHFTTLVPNLGVVKLSPEHGFIVADVPGLVKGAHKGAGLGHNFLKHV
ERCYLLVHVLDIAETEDRDFIQDYYDIRKELELHNEELAKKPEIVVGNKIDVLSDEEIEKRVKRFYDQTGKKILPISAIQ
GRNIDKLKWEMWEKIKTQKTFLKKTGVASQKKTPKVKPVSREAPDPSEFFIHKDSKGRYVVEGPAVDYYAEKFKVENQDK
FLLDKLEAGGLSERLRKMGAQEGDIVVIRGREYEYME

Sequences:

>Translated_437_residues
MIPTGESLVDTGKIFVKAGKGGDGAVSFRREKYIPFGGPDGGDGGNGGNVFIRATTSKNTLLEFQSKKKFEAEDGENGSG
GKKYGKKGKDVIIEVPVGTLVYDAETGELLADLSSPGDIVCVARGGKGGRGNVHFATSVNQAPRVAEAGEPGEERKIYLE
LKLLADVGLIGFPNTGKSTIISKISNSKPKIANYHFTTLVPNLGVVKLSPEHGFIVADVPGLVKGAHKGAGLGHNFLKHV
ERCYLLVHVLDIAETEDRDFIQDYYDIRKELELHNEELAKKPEIVVGNKIDVLSDEEIEKRVKRFYDQTGKKILPISAIQ
GRNIDKLKWEMWEKIKTQKTFLKKTGVASQKKTPKVKPVSREAPDPSEFFIHKDSKGRYVVEGPAVDYYAEKFKVENQDK
FLLDKLEAGGLSERLRKMGAQEGDIVVIRGREYEYME
>Mature_437_residues
MIPTGESLVDTGKIFVKAGKGGDGAVSFRREKYIPFGGPDGGDGGNGGNVFIRATTSKNTLLEFQSKKKFEAEDGENGSG
GKKYGKKGKDVIIEVPVGTLVYDAETGELLADLSSPGDIVCVARGGKGGRGNVHFATSVNQAPRVAEAGEPGEERKIYLE
LKLLADVGLIGFPNTGKSTIISKISNSKPKIANYHFTTLVPNLGVVKLSPEHGFIVADVPGLVKGAHKGAGLGHNFLKHV
ERCYLLVHVLDIAETEDRDFIQDYYDIRKELELHNEELAKKPEIVVGNKIDVLSDEEIEKRVKRFYDQTGKKILPISAIQ
GRNIDKLKWEMWEKIKTQKTFLKKTGVASQKKTPKVKPVSREAPDPSEFFIHKDSKGRYVVEGPAVDYYAEKFKVENQDK
FLLDKLEAGGLSERLRKMGAQEGDIVVIRGREYEYME

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=320, Percent_Identity=40.3125, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI111955139, Length=286, Percent_Identity=38.4615384615385, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI111955063, Length=181, Percent_Identity=38.121546961326, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI58761500, Length=164, Percent_Identity=32.9268292682927, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4758796, Length=271, Percent_Identity=25.4612546125461, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789574, Length=326, Percent_Identity=50, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=31.0077519379845, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790615, Length=193, Percent_Identity=26.4248704663212, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=330, Percent_Identity=39.3939393939394, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17552324, Length=308, Percent_Identity=31.8181818181818, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=161, Percent_Identity=31.055900621118, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321962, Length=215, Percent_Identity=40, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319281, Length=89, Percent_Identity=38.2022471910112, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321612, Length=92, Percent_Identity=40.2173913043478, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129375, Length=318, Percent_Identity=41.8238993710692, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24585318, Length=301, Percent_Identity=37.8737541528239, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24640873, Length=187, Percent_Identity=31.0160427807487, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640877, Length=187, Percent_Identity=31.0160427807487, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640875, Length=187, Percent_Identity=31.0160427807487, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17981711, Length=300, Percent_Identity=23.6666666666667, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 48124; Mature: 48124

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTGESLVDTGKIFVKAGKGGDGAVSFRREKYIPFGGPDGGDGGNGGNVFIRATTSKNT
CCCCCCCHHCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCE
LLEFQSKKKFEAEDGENGSGGKKYGKKGKDVIIEVPVGTLVYDAETGELLADLSSPGDIV
EEEECCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCEEEEECCCCHHHHHCCCCCCEE
CVARGGKGGRGNVHFATSVNQAPRVAEAGEPGEERKIYLELKLLADVGLIGFPNTGKSTI
EEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCHHHH
ISKISNSKPKIANYHFTTLVPNLGVVKLSPEHGFIVADVPGLVKGAHKGAGLGHNFLKHV
HHHHCCCCCCEEEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCCCHHHHHHH
ERCYLLVHVLDIAETEDRDFIQDYYDIRKELELHNEELAKKPEIVVGNKIDVLSDEEIEK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEECCCCCHHHHH
RVKRFYDQTGKKILPISAIQGRNIDKLKWEMWEKIKTQKTFLKKTGVASQKKTPKVKPVS
HHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
REAPDPSEFFIHKDSKGRYVVEGPAVDYYAEKFKVENQDKFLLDKLEAGGLSERLRKMGA
CCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHCCC
QEGDIVVIRGREYEYME
CCCCEEEEECCCCCCCC
>Mature Secondary Structure
MIPTGESLVDTGKIFVKAGKGGDGAVSFRREKYIPFGGPDGGDGGNGGNVFIRATTSKNT
CCCCCCCHHCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCE
LLEFQSKKKFEAEDGENGSGGKKYGKKGKDVIIEVPVGTLVYDAETGELLADLSSPGDIV
EEEECCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCEEEEECCCCHHHHHCCCCCCEE
CVARGGKGGRGNVHFATSVNQAPRVAEAGEPGEERKIYLELKLLADVGLIGFPNTGKSTI
EEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCHHHH
ISKISNSKPKIANYHFTTLVPNLGVVKLSPEHGFIVADVPGLVKGAHKGAGLGHNFLKHV
HHHHCCCCCCEEEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCCCHHHHHHH
ERCYLLVHVLDIAETEDRDFIQDYYDIRKELELHNEELAKKPEIVVGNKIDVLSDEEIEK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEECCCCCHHHHH
RVKRFYDQTGKKILPISAIQGRNIDKLKWEMWEKIKTQKTFLKKTGVASQKKTPKVKPVS
HHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
REAPDPSEFFIHKDSKGRYVVEGPAVDYYAEKFKVENQDKFLLDKLEAGGLSERLRKMGA
CCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHCCC
QEGDIVVIRGREYEYME
CCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA