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The map label for this gene is fhs

Identifier: 239618473

GI number: 239618473

Start: 2246853

End: 2248523

Strand: Reverse

Name: fhs

Synonym: Kole_2114

Alternate gene names: 239618473

Gene position: 2248523-2246853 (Counterclockwise)

Preceding gene: 239618474

Following gene: 239618472

Centisome position: 97.67

GC content: 44.17

Gene sequence:

>1671_bases
ATGAATGATGATCTAGCAATCGCTCAGGCCACAAAATTAAAGCCCATTGATGAAATAGCAGAATTTGCGGGCATTGAACG
TAAATATTTGAAGCCTTATGGGAATTACATTGCAAAAGTATCCCACAGAATCTATGAAGAACTGGCCCAACGCGAAGATG
GGAACCTTATTCTGGTTACCGCGATAACCCCAACAAGCGCTGGCGAGGGAAAGACGACCACTTCGATAGGGCTGTCGATG
GCGTTAAACCGCCTGGGGAAAAAATCATTCGTCACCCTCAGGGAGCCTTCAATTGGCCCCGTTATGGGAATAAAAGGCGG
GGCAGCTGGTGGGGGTTATTCGCAGGTTCTTCCAATGGAGGACATAAACCTTCATTTCACAGGGGATATTCATGCGGTGT
CACTAGCACATAATTTGCTTTCTGCTGCAATAGATGCACATTTGAAGTTTGATAACGAACTAGAAATCGATTCTACCCAG
ATATACTGGCCAAGAGCCATGGATATGAACGATCGTGCTCTCAGAAAGATTGTTGTCGGCCTCGGTGGAAAAGCCAACGG
CTATCCCCGTGAAGATAAATTTATAATAACCGCAGCGTCTGAAATAATGGCGATTCTTTGCCTGGCTAAAGATCTTGAAG
ATCTTAAAGAAAGGGTCGGAAACATCGTTATTGCGAAAAACAAAAAGAAAGAGTATGTTCTCGCAAAAGATCTCAAGGTT
CATGGGGCTATAGCTGCTCTGTTAAAGGATGCCATTGATCCGAATCTTGTTCAAACAATAGAAGGTACCCCTGCATTCAT
TCACGGCGGACCTTTTGCAAATATTGCTCATGGTACGAATTCTATAATAGCTACAAAGATTGCCTTGAAACTATCTGATT
ATGTGGTTACCGAGGCTGGATTTGGGGCAGATCTTGGTGGAGAAAAGTTCCTGAATTTTGTCAGCCAGGTAGCTGGATTC
AAACCGTCGGTGGTTGTGCTAGTTGCTTCGTTACGCGCGTTAAAGCTTCATGGTGGAGCAAAGAAAGACAGTATAACCGA
GGAGAACCTGGAAGCTCTTGAGAAAGGCTTCGTGAATCTTCAGGTTCATTATGAAAACCTGAGAAAATTTGGGGTACCTG
TATTAACAGCGTTAAACGTATTTCCAACTGACACAGATTCCGAGAAGAAGCTCTTTGAAAAACTTTGCGAAAAACACGGG
ATTCCCTTCGGAGAATCCAGAGTTTGGGCTAAAGGTGGAAAAGGCGGAGAAGCTCTTGCAAGAGAAGTCATAAAGCTGGC
CGAAACCCACACTTCAGAGTATCACCCGTTGTATTTAATGGATACCCCGATAGAAGAGAAATTGGATATCTTGACGCGAG
AAATCTATCGTGCAAAAGGTTATGAGCTTTCTCCCACAGCGAAAGCGAAGTTGCGAAGTTTTAAAAAGAATGGATTTGGG
AATGCACCGGTTATTGTGGCGAAAACCCAGTACTCAATCTCGGACAATCCGAAACTTCTTGGGGCACCAAAAGATTATAT
TTTCAATATTCGAGACTTGAATTTATCCGCAGGTGCTGGTTTTGTTGTTGCGGTCTCGGGAGATATCATGCTGATGCCCG
GCCTGGGAAAGGAATTTGGTGCTCAAAGGATCGACATTGACAAAAGCGGAAAGATTTCCGGACTATTCTGA

Upstream 100 bases:

>100_bases
GGTTCACAAGAAGAGGGGAAGTTCGTCAACGGTGTCCTGGACAAGATAGCTAAAGAGAGGGTTTCAGAAGAAAAGAGAGC
CCTTTAAGAGGTGGAAGGTT

Downstream 100 bases:

>100_bases
GGGGTGTGAAATGGGTATACTTTTAGATGGTAAGCCAGTGGCAAAAATGATTTACGCGGAAATAAAAGAGTGGTTGGGTA
ATCTTCAGGAGAAACCACCG

Product: Formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MNDDLAIAQATKLKPIDEIAEFAGIERKYLKPYGNYIAKVSHRIYEELAQREDGNLILVTAITPTSAGEGKTTTSIGLSM
ALNRLGKKSFVTLREPSIGPVMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAVSLAHNLLSAAIDAHLKFDNELEIDSTQ
IYWPRAMDMNDRALRKIVVGLGGKANGYPREDKFIITAASEIMAILCLAKDLEDLKERVGNIVIAKNKKKEYVLAKDLKV
HGAIAALLKDAIDPNLVQTIEGTPAFIHGGPFANIAHGTNSIIATKIALKLSDYVVTEAGFGADLGGEKFLNFVSQVAGF
KPSVVVLVASLRALKLHGGAKKDSITEENLEALEKGFVNLQVHYENLRKFGVPVLTALNVFPTDTDSEKKLFEKLCEKHG
IPFGESRVWAKGGKGGEALAREVIKLAETHTSEYHPLYLMDTPIEEKLDILTREIYRAKGYELSPTAKAKLRSFKKNGFG
NAPVIVAKTQYSISDNPKLLGAPKDYIFNIRDLNLSAGAGFVVAVSGDIMLMPGLGKEFGAQRIDIDKSGKISGLF

Sequences:

>Translated_556_residues
MNDDLAIAQATKLKPIDEIAEFAGIERKYLKPYGNYIAKVSHRIYEELAQREDGNLILVTAITPTSAGEGKTTTSIGLSM
ALNRLGKKSFVTLREPSIGPVMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAVSLAHNLLSAAIDAHLKFDNELEIDSTQ
IYWPRAMDMNDRALRKIVVGLGGKANGYPREDKFIITAASEIMAILCLAKDLEDLKERVGNIVIAKNKKKEYVLAKDLKV
HGAIAALLKDAIDPNLVQTIEGTPAFIHGGPFANIAHGTNSIIATKIALKLSDYVVTEAGFGADLGGEKFLNFVSQVAGF
KPSVVVLVASLRALKLHGGAKKDSITEENLEALEKGFVNLQVHYENLRKFGVPVLTALNVFPTDTDSEKKLFEKLCEKHG
IPFGESRVWAKGGKGGEALAREVIKLAETHTSEYHPLYLMDTPIEEKLDILTREIYRAKGYELSPTAKAKLRSFKKNGFG
NAPVIVAKTQYSISDNPKLLGAPKDYIFNIRDLNLSAGAGFVVAVSGDIMLMPGLGKEFGAQRIDIDKSGKISGLF
>Mature_556_residues
MNDDLAIAQATKLKPIDEIAEFAGIERKYLKPYGNYIAKVSHRIYEELAQREDGNLILVTAITPTSAGEGKTTTSIGLSM
ALNRLGKKSFVTLREPSIGPVMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAVSLAHNLLSAAIDAHLKFDNELEIDSTQ
IYWPRAMDMNDRALRKIVVGLGGKANGYPREDKFIITAASEIMAILCLAKDLEDLKERVGNIVIAKNKKKEYVLAKDLKV
HGAIAALLKDAIDPNLVQTIEGTPAFIHGGPFANIAHGTNSIIATKIALKLSDYVVTEAGFGADLGGEKFLNFVSQVAGF
KPSVVVLVASLRALKLHGGAKKDSITEENLEALEKGFVNLQVHYENLRKFGVPVLTALNVFPTDTDSEKKLFEKLCEKHG
IPFGESRVWAKGGKGGEALAREVIKLAETHTSEYHPLYLMDTPIEEKLDILTREIYRAKGYELSPTAKAKLRSFKKNGFG
NAPVIVAKTQYSISDNPKLLGAPKDYIFNIRDLNLSAGAGFVVAVSGDIMLMPGLGKEFGAQRIDIDKSGKISGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=44.1033925686591, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI36796743, Length=621, Percent_Identity=42.6731078904992, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI310124614, Length=85, Percent_Identity=40, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=41.8006430868167, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=41.8006430868167, Blast_Score=415, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=41.28, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319558, Length=630, Percent_Identity=40.6349206349206, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=41.8416801292407, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=41.8416801292407, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=41.8416801292407, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=41.8416801292407, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_KOSOT (C5CI89)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002941795.1
- GeneID:   7968526
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_2114
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60300; Mature: 60300

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDLAIAQATKLKPIDEIAEFAGIERKYLKPYGNYIAKVSHRIYEELAQREDGNLILVT
CCCCCEEEHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
AITPTSAGEGKTTTSIGLSMALNRLGKKSFVTLREPSIGPVMGIKGGAAGGGYSQVLPME
EECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
DINLHFTGDIHAVSLAHNLLSAAIDAHLKFDNELEIDSTQIYWPRAMDMNDRALRKIVVG
CCCEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHH
LGGKANGYPREDKFIITAASEIMAILCLAKDLEDLKERVGNIVIAKNKKKEYVLAKDLKV
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHH
HGAIAALLKDAIDPNLVQTIEGTPAFIHGGPFANIAHGTNSIIATKIALKLSDYVVTEAG
HHHHHHHHHHCCCCCHHHHCCCCCEEEECCCCCEECCCCCCEEEHHHEEEHHCEEEECCC
FGADLGGEKFLNFVSQVAGFKPSVVVLVASLRALKLHGGAKKDSITEENLEALEKGFVNL
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCCEEE
QVHYENLRKFGVPVLTALNVFPTDTDSEKKLFEKLCEKHGIPFGESRVWAKGGKGGEALA
EEEHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHH
REVIKLAETHTSEYHPLYLMDTPIEEKLDILTREIYRAKGYELSPTAKAKLRSFKKNGFG
HHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
NAPVIVAKTQYSISDNPKLLGAPKDYIFNIRDLNLSAGAGFVVAVSGDIMLMPGLGKEFG
CCCEEEEEEEECCCCCCEEECCCHHHEEEEEEECCCCCCCEEEEEECCEEECCCCCHHHC
AQRIDIDKSGKISGLF
CCEECCCCCCCCCCCC
>Mature Secondary Structure
MNDDLAIAQATKLKPIDEIAEFAGIERKYLKPYGNYIAKVSHRIYEELAQREDGNLILVT
CCCCCEEEHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
AITPTSAGEGKTTTSIGLSMALNRLGKKSFVTLREPSIGPVMGIKGGAAGGGYSQVLPME
EECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
DINLHFTGDIHAVSLAHNLLSAAIDAHLKFDNELEIDSTQIYWPRAMDMNDRALRKIVVG
CCCEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHH
LGGKANGYPREDKFIITAASEIMAILCLAKDLEDLKERVGNIVIAKNKKKEYVLAKDLKV
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHH
HGAIAALLKDAIDPNLVQTIEGTPAFIHGGPFANIAHGTNSIIATKIALKLSDYVVTEAG
HHHHHHHHHHCCCCCHHHHCCCCCEEEECCCCCEECCCCCCEEEHHHEEEHHCEEEECCC
FGADLGGEKFLNFVSQVAGFKPSVVVLVASLRALKLHGGAKKDSITEENLEALEKGFVNL
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCCEEE
QVHYENLRKFGVPVLTALNVFPTDTDSEKKLFEKLCEKHGIPFGESRVWAKGGKGGEALA
EEEHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHH
REVIKLAETHTSEYHPLYLMDTPIEEKLDILTREIYRAKGYELSPTAKAKLRSFKKNGFG
HHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
NAPVIVAKTQYSISDNPKLLGAPKDYIFNIRDLNLSAGAGFVVAVSGDIMLMPGLGKEFG
CCCEEEEEEEECCCCCCEEECCCHHHEEEEEEECCCCCCCEEEEEECCEEECCCCCHHHC
AQRIDIDKSGKISGLF
CCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA