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The map label for this gene is folK [H]

Identifier: 239618118

GI number: 239618118

Start: 1882048

End: 1882572

Strand: Direct

Name: folK [H]

Synonym: Kole_1750

Alternate gene names: 239618118

Gene position: 1882048-1882572 (Clockwise)

Preceding gene: 239618117

Following gene: 239618119

Centisome position: 81.75

GC content: 41.33

Gene sequence:

>525_bases
ATGTCTGATGTTTATCTTGCATTTGGTAGTAACATTGGAGATAGATTGAGTTACATAGTGAAGAGTATCTGTTTATTGGC
AGAGAGAGAAATTGAACTACTTTCCCTGTCGTCTATATATGAAACGGAGCCTTATGGTTATACTGAACAGGAGCCATTTT
TGAACTGTGTTGGACTGTTTGATTTTTCCGGGACCCCGGAGGAGCTTTTGAAAAGGACTATGTCTGTCGAGAAACTGCTG
GGAAGAAAGCGAGAAATGAGATGGGGACCGAGAACAATAGATATAGACATACTCCTTTTCGATAAAATAGTGTACGAAGA
CGAGAATTTAAAAATCCCCCACTACGATATGGAGAACCGTATTTTCGTCATCAAGCCATTGTTGGAGATTGATCCATATC
TTACGAATCCTGAAACAGGGCAGCCTTATGCGGAACTCCTGGAGAAACTGGAAAAAACAGCGGATGCAAACAGAATCATG
AGTGGGAATGACCTTTTCCACAAGGTAAAAGCCTTTTGCGGGTAG

Upstream 100 bases:

>100_bases
AATTCTTTGCTTCCCTACTGGTGGGAAGAGAGTTTGAGTATCGCACAACTCAAACTGCTGAAAGAAAAAAGCTGGAGAGT
AAAGGAGAGACTGTTAAGTC

Downstream 100 bases:

>100_bases
GTTGATCTGAGGATTCTCCATCGGAGGTGTTCTGATGAAAATTCGCGATTTAAAAAAAATCTTGTTTCTTACGTTCCTGG
TGGTTTTTGTGGGATCTTGT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MSDVYLAFGSNIGDRLSYIVKSICLLAEREIELLSLSSIYETEPYGYTEQEPFLNCVGLFDFSGTPEELLKRTMSVEKLL
GRKREMRWGPRTIDIDILLFDKIVYEDENLKIPHYDMENRIFVIKPLLEIDPYLTNPETGQPYAELLEKLEKTADANRIM
SGNDLFHKVKAFCG

Sequences:

>Translated_174_residues
MSDVYLAFGSNIGDRLSYIVKSICLLAEREIELLSLSSIYETEPYGYTEQEPFLNCVGLFDFSGTPEELLKRTMSVEKLL
GRKREMRWGPRTIDIDILLFDKIVYEDENLKIPHYDMENRIFVIKPLLEIDPYLTNPETGQPYAELLEKLEKTADANRIM
SGNDLFHKVKAFCG
>Mature_173_residues
SDVYLAFGSNIGDRLSYIVKSICLLAEREIELLSLSSIYETEPYGYTEQEPFLNCVGLFDFSGTPEELLKRTMSVEKLLG
RKREMRWGPRTIDIDILLFDKIVYEDENLKIPHYDMENRIFVIKPLLEIDPYLTNPETGQPYAELLEKLEKTADANRIMS
GNDLFHKVKAFCG

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=140, Percent_Identity=42.1428571428571, Blast_Score=110, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324073, Length=155, Percent_Identity=40, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20111; Mature: 19980

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVYLAFGSNIGDRLSYIVKSICLLAEREIELLSLSSIYETEPYGYTEQEPFLNCVGLF
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHEEHHHHHCCCCCCCCCCCCCCEEEEEC
DFSGTPEELLKRTMSVEKLLGRKREMRWGPRTIDIDILLFDKIVYEDENLKIPHYDMENR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHEECCCCCCCCCCCCCCC
IFVIKPLLEIDPYLTNPETGQPYAELLEKLEKTADANRIMSGNDLFHKVKAFCG
EEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SDVYLAFGSNIGDRLSYIVKSICLLAEREIELLSLSSIYETEPYGYTEQEPFLNCVGLF
CCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHEEHHHHHCCCCCCCCCCCCCCEEEEEC
DFSGTPEELLKRTMSVEKLLGRKREMRWGPRTIDIDILLFDKIVYEDENLKIPHYDMENR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHEECCCCCCCCCCCCCCC
IFVIKPLLEIDPYLTNPETGQPYAELLEKLEKTADANRIMSGNDLFHKVKAFCG
EEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]