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The map label for this gene is vvpD [H]

Identifier: 239618069

GI number: 239618069

Start: 1829606

End: 1830361

Strand: Direct

Name: vvpD [H]

Synonym: Kole_1699

Alternate gene names: 239618069

Gene position: 1829606-1830361 (Clockwise)

Preceding gene: 239618068

Following gene: 239618071

Centisome position: 79.47

GC content: 43.12

Gene sequence:

>756_bases
ATGGCTGTAGTTTCCTTCATCTTTGGTCTGGTTTTTGGAAGCTTTTTTAATGTGGTAATTTATCGATTGCCGAGGAAAGA
ATACACCATAAATAGACCTGCACGGAGTTTTTGTCCTTCGTGCGGCCATGAGCTGGTGTGGAAGGACAATATACCATTAT
TGAGTTATATTGTTCTTAGAGGAAGGTGCAGGTATTGCGGAACCAGAATACCGATAAGATATCCAGTAGTAGAAGCTATT
ACAGCGGTTTCTTTTACAATCAACGCGCTTATATTTCCTGTTCCGCAGGCGCTGGCCCTTGATCTGGTTGCGGCGGGATT
GATTATTTCGAGCTTTATCGATCTGGAACATTACTTGATACCCGATACGGGAATAATCCTTATCGGGATTGGTGCGGTTC
TCTTTTCCTATTATCAGGGGAGATTTCCAGAAATTTTGATTCATGCTGCCCTTGTGACTGGGGCAATGGTCGCGTTTTTC
TTGATTGCCAACGCCGTGAAGAAAGATTCCTTTGGTTTTGGTGATGTTGAACTTATAGGTGCACTTTCCCTGGCAAGTGG
TTTACTTGGGTCCTTATATACGGTTCTTTTTTCTTCGATAGCTGCTCTTCTGACGTATCTGGTGATTATTGGGGTGAAAG
GTGAAAAATTTGAAGGAACGAAGCAGATTCCTTTTGGCCCGTTTATAGCTATCGGTGGGTATACCGCTATTCTTCTTCTT
GATGAACTCAGGCTTCTTTATGGATTGGTGGGGTAG

Upstream 100 bases:

>100_bases
AAGAATTCAAAAACAACGAGATGTGGTACTATTACGGTAAGAAGGAGCTTTTTGATGAATTCCTGACAAACGATGAGAGA
AAGGCTTGTGGAATCCTTTG

Downstream 100 bases:

>100_bases
AATTCCCCGATTTTTCTTTAAGTGTCGATTTTAGTGGTTAGATTTTCAAGGAAGTTTTCTACTACCTTTCTCCGGGATCT
TTTGTCAAAGCAATACATTG

Product: peptidase A24A domain protein

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MAVVSFIFGLVFGSFFNVVIYRLPRKEYTINRPARSFCPSCGHELVWKDNIPLLSYIVLRGRCRYCGTRIPIRYPVVEAI
TAVSFTINALIFPVPQALALDLVAAGLIISSFIDLEHYLIPDTGIILIGIGAVLFSYYQGRFPEILIHAALVTGAMVAFF
LIANAVKKDSFGFGDVELIGALSLASGLLGSLYTVLFSSIAALLTYLVIIGVKGEKFEGTKQIPFGPFIAIGGYTAILLL
DELRLLYGLVG

Sequences:

>Translated_251_residues
MAVVSFIFGLVFGSFFNVVIYRLPRKEYTINRPARSFCPSCGHELVWKDNIPLLSYIVLRGRCRYCGTRIPIRYPVVEAI
TAVSFTINALIFPVPQALALDLVAAGLIISSFIDLEHYLIPDTGIILIGIGAVLFSYYQGRFPEILIHAALVTGAMVAFF
LIANAVKKDSFGFGDVELIGALSLASGLLGSLYTVLFSSIAALLTYLVIIGVKGEKFEGTKQIPFGPFIAIGGYTAILLL
DELRLLYGLVG
>Mature_250_residues
AVVSFIFGLVFGSFFNVVIYRLPRKEYTINRPARSFCPSCGHELVWKDNIPLLSYIVLRGRCRYCGTRIPIRYPVVEAIT
AVSFTINALIFPVPQALALDLVAAGLIISSFIDLEHYLIPDTGIILIGIGAVLFSYYQGRFPEILIHAALVTGAMVAFFL
IANAVKKDSFGFGDVELIGALSLASGLLGSLYTVLFSSIAALLTYLVIIGVKGEKFEGTKQIPFGPFIAIGGYTAILLLD
ELRLLYGLVG

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=267, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27323; Mature: 27192

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVSFIFGLVFGSFFNVVIYRLPRKEYTINRPARSFCPSCGHELVWKDNIPLLSYIVLR
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCEECCCCHHHHHHHHH
GRCRYCGTRIPIRYPVVEAITAVSFTINALIFPVPQALALDLVAAGLIISSFIDLEHYLI
CCHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDTGIILIGIGAVLFSYYQGRFPEILIHAALVTGAMVAFFLIANAVKKDSFGFGDVELIG
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALSLASGLLGSLYTVLFSSIAALLTYLVIIGVKGEKFEGTKQIPFGPFIAIGGYTAILLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
DELRLLYGLVG
HHHHHHHHCCC
>Mature Secondary Structure 
AVVSFIFGLVFGSFFNVVIYRLPRKEYTINRPARSFCPSCGHELVWKDNIPLLSYIVLR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCEECCCCHHHHHHHHH
GRCRYCGTRIPIRYPVVEAITAVSFTINALIFPVPQALALDLVAAGLIISSFIDLEHYLI
CCHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDTGIILIGIGAVLFSYYQGRFPEILIHAALVTGAMVAFFLIANAVKKDSFGFGDVELIG
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALSLASGLLGSLYTVLFSSIAALLTYLVIIGVKGEKFEGTKQIPFGPFIAIGGYTAILLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
DELRLLYGLVG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9826339 [H]