Click here to switch to the map view.

The map label for this gene is 239617786

Identifier: 239617786

GI number: 239617786

Start: 1503811

End: 1505136

Strand: Reverse

Name: 239617786

Synonym: Kole_1411

Alternate gene names: NA

Gene position: 1505136-1503811 (Counterclockwise)

Preceding gene: 239617788

Following gene: 239617784

Centisome position: 65.38

GC content: 40.5

Gene sequence:

>1326_bases
ATGCGTTTTGTACCATTAGGTGGTGGAAAAGAAATAGGAGCAAACAGTTATCTGTTGCAGGTTGATGGAAAGAATATCCT
GATAGATTGCGGTCGGCACCCGATTAAAGAGGGTTACGAATCGTTACCAGCTATCGATGAAATAGACAAGCTCGATTATG
TTTTCATATCTCACTCTCACTACGATCATCTTTCATCATTACCACATCTTGTGAAATTTTTTCCAAATGTTCGTGTTTTA
ACCTCAAGAGAAAACAAAAAGCTTTCGGTAAGGATTCTCCGCAATTCAGTAGAGGTAATGAAGAAGAAAAACGAAAAAGA
TGGCGAGCCGATACTTTACAACCATTCAGATGTGAAGAAAGCTAAAAAGAGAATGATAGGAGTGGAATATTACGAACCAT
TCAAGATTTCTAAAAAGCTGTTCGTAACCTTTTATCCAGCCGGGCATGTAATGGGGGCCAGTTCTATATTGCTCGAATAT
AAAGGAAAGAAGATTTTCTATACAGGTGACATCTCTCTTTCTGACCAATTAACAATTCCTTCTGCTGTTTTGCCCGACAA
AGTCGACGTTTTAATCTCTGAAGGGACCTATGGACTTAAGGAAGAAGCGACCGACACACGGCATTCTGAAATACGTCGGC
TGGAGCTCTCAATAAAAAAAGTTCTAAAAAACAAAGGCCGCGTACTCTTGCCAGTTTTTGCACTTGGGAGAGGCCAGGAA
GTTCTTTACATGATCCTAAAAATGCTGGATGAAGAAAAGATCCCGGATGTTCCAGTTTATACAAACGGCATGGTTTCCAT
CATAACAAACCTCTACCTTCAGGAATACGCCGGCATGCCACCGGAAAAGAAAAAGTGGTTTAATAATGCCATCTTAAGAA
GGGTCCGAACCGTTCCAAAAAATTACAAAACACTTCTATACGACAAAAGACCCATGATACTCATTCTCAGCTCAGGAATG
CTCATAGAAGATACTTTATCTTATTTATTCGCAAAGGAAATCCTTCAAGACAACCTGAGCGCTATCTTTTTCATGGGCTA
CCAGAGCCCGGAATCCATTGGTTACTCCATACTTGAAGCCGCCAGAAGCAGAGAAGAAGAAATTTCATATGGTGAGGAAA
GGATTCAGCTCAGATGTACAGTTAAAAAATTCAACTTTTCTGGCCACGCTAGCTACGAAGAACTGATTTCACTTCCCAGA
GAACTCCAACCTTCAAAACTTGTATACGTACACGGAGATGAAGAGGCACTTTTGAACCTTTCAAAAGAGCTGGAATATGA
ATTTGACATATCCGTGCCATCGAACCTCGAAACGGTACTTCTTTAG

Upstream 100 bases:

>100_bases
ACCAACAACGTACAATTGCCGCGCAGCGGCTTTCTCGGATTCTCGGATCTCGATTTCCGGCTCTTGGTTCTCGATCATAG
CGAAAAATAGGAGGAAATGT

Downstream 100 bases:

>100_bases
TGGATACAAAGCTCTAAGGATCTTGACAACCTTTTTTGTAGGTGTTATGATAATAAACGGCGCCGGGGTGGCGGAATTGG
CAGACGCAACGGACTTAAAA

Product: beta-lactamase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRFVPLGGGKEIGANSYLLQVDGKNILIDCGRHPIKEGYESLPAIDEIDKLDYVFISHSHYDHLSSLPHLVKFFPNVRVL
TSRENKKLSVRILRNSVEVMKKKNEKDGEPILYNHSDVKKAKKRMIGVEYYEPFKISKKLFVTFYPAGHVMGASSILLEY
KGKKIFYTGDISLSDQLTIPSAVLPDKVDVLISEGTYGLKEEATDTRHSEIRRLELSIKKVLKNKGRVLLPVFALGRGQE
VLYMILKMLDEEKIPDVPVYTNGMVSIITNLYLQEYAGMPPEKKKWFNNAILRRVRTVPKNYKTLLYDKRPMILILSSGM
LIEDTLSYLFAKEILQDNLSAIFFMGYQSPESIGYSILEAARSREEEISYGEERIQLRCTVKKFNFSGHASYEELISLPR
ELQPSKLVYVHGDEEALLNLSKELEYEFDISVPSNLETVLL

Sequences:

>Translated_441_residues
MRFVPLGGGKEIGANSYLLQVDGKNILIDCGRHPIKEGYESLPAIDEIDKLDYVFISHSHYDHLSSLPHLVKFFPNVRVL
TSRENKKLSVRILRNSVEVMKKKNEKDGEPILYNHSDVKKAKKRMIGVEYYEPFKISKKLFVTFYPAGHVMGASSILLEY
KGKKIFYTGDISLSDQLTIPSAVLPDKVDVLISEGTYGLKEEATDTRHSEIRRLELSIKKVLKNKGRVLLPVFALGRGQE
VLYMILKMLDEEKIPDVPVYTNGMVSIITNLYLQEYAGMPPEKKKWFNNAILRRVRTVPKNYKTLLYDKRPMILILSSGM
LIEDTLSYLFAKEILQDNLSAIFFMGYQSPESIGYSILEAARSREEEISYGEERIQLRCTVKKFNFSGHASYEELISLPR
ELQPSKLVYVHGDEEALLNLSKELEYEFDISVPSNLETVLL
>Mature_441_residues
MRFVPLGGGKEIGANSYLLQVDGKNILIDCGRHPIKEGYESLPAIDEIDKLDYVFISHSHYDHLSSLPHLVKFFPNVRVL
TSRENKKLSVRILRNSVEVMKKKNEKDGEPILYNHSDVKKAKKRMIGVEYYEPFKISKKLFVTFYPAGHVMGASSILLEY
KGKKIFYTGDISLSDQLTIPSAVLPDKVDVLISEGTYGLKEEATDTRHSEIRRLELSIKKVLKNKGRVLLPVFALGRGQE
VLYMILKMLDEEKIPDVPVYTNGMVSIITNLYLQEYAGMPPEKKKWFNNAILRRVRTVPKNYKTLLYDKRPMILILSSGM
LIEDTLSYLFAKEILQDNLSAIFFMGYQSPESIGYSILEAARSREEEISYGEERIQLRCTVKKFNFSGHASYEELISLPR
ELQPSKLVYVHGDEEALLNLSKELEYEFDISVPSNLETVLL

Specific function: Unknown

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=453, Percent_Identity=28.476821192053, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI33300633, Length=457, Percent_Identity=26.4770240700219, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32566029, Length=443, Percent_Identity=27.765237020316, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI32564696, Length=454, Percent_Identity=27.5330396475771, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323307, Length=456, Percent_Identity=28.0701754385965, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24648013, Length=446, Percent_Identity=29.1479820627803, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21358523, Length=457, Percent_Identity=27.3522975929978, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50461; Mature: 50461

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVPLGGGKEIGANSYLLQVDGKNILIDCGRHPIKEGYESLPAIDEIDKLDYVFISHSH
CEEECCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCHHHHCCCEEEEEECCC
YDHLSSLPHLVKFFPNVRVLTSRENKKLSVRILRNSVEVMKKKNEKDGEPILYNHSDVKK
HHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCCCEEECCHHHHH
AKKRMIGVEYYEPFKISKKLFVTFYPAGHVMGASSILLEYKGKKIFYTGDISLSDQLTIP
HHHHHCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
SAVLPDKVDVLISEGTYGLKEEATDTRHSEIRRLELSIKKVLKNKGRVLLPVFALGRGQE
CCCCCCCEEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VLYMILKMLDEEKIPDVPVYTNGMVSIITNLYLQEYAGMPPEKKKWFNNAILRRVRTVPK
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
NYKTLLYDKRPMILILSSGMLIEDTLSYLFAKEILQDNLSAIFFMGYQSPESIGYSILEA
CCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHH
ARSREEEISYGEERIQLRCTVKKFNFSGHASYEELISLPRELQPSKLVYVHGDEEALLNL
HHCCHHHHCCCCEEEEEEEEEEEECCCCCCCHHHHHCCCCCCCCCEEEEEECCHHHHHHH
SKELEYEFDISVPSNLETVLL
HHHCCEEEECCCCCCCCEEEC
>Mature Secondary Structure
MRFVPLGGGKEIGANSYLLQVDGKNILIDCGRHPIKEGYESLPAIDEIDKLDYVFISHSH
CEEECCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCHHHHCCCEEEEEECCC
YDHLSSLPHLVKFFPNVRVLTSRENKKLSVRILRNSVEVMKKKNEKDGEPILYNHSDVKK
HHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCCCEEECCHHHHH
AKKRMIGVEYYEPFKISKKLFVTFYPAGHVMGASSILLEYKGKKIFYTGDISLSDQLTIP
HHHHHCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
SAVLPDKVDVLISEGTYGLKEEATDTRHSEIRRLELSIKKVLKNKGRVLLPVFALGRGQE
CCCCCCCEEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VLYMILKMLDEEKIPDVPVYTNGMVSIITNLYLQEYAGMPPEKKKWFNNAILRRVRTVPK
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
NYKTLLYDKRPMILILSSGMLIEDTLSYLFAKEILQDNLSAIFFMGYQSPESIGYSILEA
CCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHH
ARSREEEISYGEERIQLRCTVKKFNFSGHASYEELISLPRELQPSKLVYVHGDEEALLNL
HHCCHHHHCCCCEEEEEEEEEEEECCCCCCCHHHHHCCCCCCCCCEEEEEECCHHHHHHH
SKELEYEFDISVPSNLETVLL
HHHCCEEEECCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]