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The map label for this gene is cysK [H]

Identifier: 239617720

GI number: 239617720

Start: 1424652

End: 1425551

Strand: Reverse

Name: cysK [H]

Synonym: Kole_1344

Alternate gene names: 239617720

Gene position: 1425551-1424652 (Counterclockwise)

Preceding gene: 239617721

Following gene: 239617714

Centisome position: 61.92

GC content: 44.78

Gene sequence:

>900_bases
ATGAGATTGCGTGAACTTATAGGAAATACCCCTATGATTTTGCTGAAATCCCTTGGAAACGATGATAGGGAGATTCTTTT
AAAACTTGAGAAGAACAACCCAGGTGGGAGCATTAAGGATAGAACAGTGCTCGGGATGATTATCGATGCAGAAAAGAGGG
GAATCCTTTCTCCAGGAGCTACGATAGTCGAACCTACAAGTGGAAACACCGGGATAGCGATCGCAATGTTGTCGGCCGTT
CGAGGATACAGAGCGGTAATGGTAATGCCGGAAAGCATGAGTCAGGAAAGAATCAAGGTTTTAAAGGCCTTTGGTGCTGA
GGTTATATTGACACCCGCAGATTTGGGTATGAACGGTTCCAGACAGAAAGCTCTGGAAATAGTTAAAAACGAGCCTTCAG
CAGTGATGCTCAATCAGTTCTCAAATCCGGCGAATCCTTTGATTCATGAGTTAACCACCGGACCTGAAATACTTGTGCAG
GCTGAATTTGATATTGATGCATTTGTTTGTGGAATAGGTACAGGTGGAACTGTTACCGGTGTTGGCCGTGCTCTGAAGAA
AGTGCTTCCAAACGTAAAAATCTACGGTGTCGAACCGGCAGGTTCACCGGTTATAACAGAAAACAGGAGCGGAAAACACA
AAATACAGGGAATTGGTGCTGGTTTCATACCCGATATCCTTGATCTCAAATTACTGGACGGTGTCTTAACGGTCACCGAT
GAAGAAGCTATAGAGATGACAAAATATCTTCAAAGAAAAGAAGGATTGCTGGTTGGTATCTCTTCCGGTGCAAATGTGGC
TGCAGCGCTGCGTTTGTCTAAAGAAGGATTCCGTAGAGTGGTAACAATAGCGCCGGATCATCTTGAACGCTACCTTAGCA
GCGGCATAATCACCGATTGA

Upstream 100 bases:

>100_bases
GCTAATAGCGTTGTTCTGGAACATGTCCAACCCAATACCACTGTGGTTGGTATTCCAGCACGTCCTGTTAGTAAATTTTG
TAAATGTGAGGTGCAAGAGG

Downstream 100 bases:

>100_bases
CGCTTAGATTGCCTTCGGTAATGAAGTGCGGGGCTTCGCCCCGGAGGCTCACGACGTTGTCAGCTGATGAGGCGCCGCTT
GCAAGGCCGTCATCCCGAGC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MRLRELIGNTPMILLKSLGNDDREILLKLEKNNPGGSIKDRTVLGMIIDAEKRGILSPGATIVEPTSGNTGIAIAMLSAV
RGYRAVMVMPESMSQERIKVLKAFGAEVILTPADLGMNGSRQKALEIVKNEPSAVMLNQFSNPANPLIHELTTGPEILVQ
AEFDIDAFVCGIGTGGTVTGVGRALKKVLPNVKIYGVEPAGSPVITENRSGKHKIQGIGAGFIPDILDLKLLDGVLTVTD
EEAIEMTKYLQRKEGLLVGISSGANVAAALRLSKEGFRRVVTIAPDHLERYLSSGIITD

Sequences:

>Translated_299_residues
MRLRELIGNTPMILLKSLGNDDREILLKLEKNNPGGSIKDRTVLGMIIDAEKRGILSPGATIVEPTSGNTGIAIAMLSAV
RGYRAVMVMPESMSQERIKVLKAFGAEVILTPADLGMNGSRQKALEIVKNEPSAVMLNQFSNPANPLIHELTTGPEILVQ
AEFDIDAFVCGIGTGGTVTGVGRALKKVLPNVKIYGVEPAGSPVITENRSGKHKIQGIGAGFIPDILDLKLLDGVLTVTD
EEAIEMTKYLQRKEGLLVGISSGANVAAALRLSKEGFRRVVTIAPDHLERYLSSGIITD
>Mature_299_residues
MRLRELIGNTPMILLKSLGNDDREILLKLEKNNPGGSIKDRTVLGMIIDAEKRGILSPGATIVEPTSGNTGIAIAMLSAV
RGYRAVMVMPESMSQERIKVLKAFGAEVILTPADLGMNGSRQKALEIVKNEPSAVMLNQFSNPANPLIHELTTGPEILVQ
AEFDIDAFVCGIGTGGTVTGVGRALKKVLPNVKIYGVEPAGSPVITENRSGKHKIQGIGAGFIPDILDLKLLDGVLTVTD
EEAIEMTKYLQRKEGLLVGISSGANVAAALRLSKEGFRRVVTIAPDHLERYLSSGIITD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=300, Percent_Identity=42.6666666666667, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI295821200, Length=300, Percent_Identity=42.6666666666667, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI4557415, Length=300, Percent_Identity=42.6666666666667, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=27.3648648648649, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=52.4590163934426, Blast_Score=260, Evalue=9e-71,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=43.7710437710438, Blast_Score=234, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=48.3333333333333, Blast_Score=260, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=48.494983277592, Blast_Score=246, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=44.6666666666667, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=45.7337883959044, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=44.1471571906354, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=44.392523364486, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17534315, Length=314, Percent_Identity=38.2165605095541, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=311, Percent_Identity=36.3344051446945, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17539640, Length=201, Percent_Identity=28.8557213930348, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=40, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996324, Length=310, Percent_Identity=24.8387096774194, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=311, Percent_Identity=38.9067524115756, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=36.6153846153846, Blast_Score=141, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24643623, Length=303, Percent_Identity=39.2739273927393, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129101, Length=303, Percent_Identity=39.2739273927393, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31946; Mature: 31946

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRELIGNTPMILLKSLGNDDREILLKLEKNNPGGSIKDRTVLGMIIDAEKRGILSPGA
CCCHHHHCCCCEEHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCC
TIVEPTSGNTGIAIAMLSAVRGYRAVMVMPESMSQERIKVLKAFGAEVILTPADLGMNGS
EEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
RQKALEIVKNEPSAVMLNQFSNPANPLIHELTTGPEILVQAEFDIDAFVCGIGTGGTVTG
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCHHH
VGRALKKVLPNVKIYGVEPAGSPVITENRSGKHKIQGIGAGFIPDILDLKLLDGVLTVTD
HHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEEEEECCCCCCHHHHHHHHHCCEEEECC
EEAIEMTKYLQRKEGLLVGISSGANVAAALRLSKEGFRRVVTIAPDHLERYLSSGIITD
HHHHHHHHHHHHHCCEEEEECCCCCEEEHEEECHHCCEEEEEECHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLRELIGNTPMILLKSLGNDDREILLKLEKNNPGGSIKDRTVLGMIIDAEKRGILSPGA
CCCHHHHCCCCEEHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCC
TIVEPTSGNTGIAIAMLSAVRGYRAVMVMPESMSQERIKVLKAFGAEVILTPADLGMNGS
EEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
RQKALEIVKNEPSAVMLNQFSNPANPLIHELTTGPEILVQAEFDIDAFVCGIGTGGTVTG
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCHHH
VGRALKKVLPNVKIYGVEPAGSPVITENRSGKHKIQGIGAGFIPDILDLKLLDGVLTVTD
HHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEEEEECCCCCCHHHHHHHHHCCEEEECC
EEAIEMTKYLQRKEGLLVGISSGANVAAALRLSKEGFRRVVTIAPDHLERYLSSGIITD
HHHHHHHHHHHHHCCEEEEECCCCCEEEHEEECHHCCEEEEEECHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA