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The map label for this gene is celR [H]

Identifier: 239617580

GI number: 239617580

Start: 1273525

End: 1274514

Strand: Direct

Name: celR [H]

Synonym: Kole_1199

Alternate gene names: 239617580

Gene position: 1273525-1274514 (Clockwise)

Preceding gene: 239617578

Following gene: 239617581

Centisome position: 55.32

GC content: 40.51

Gene sequence:

>990_bases
ATGCGTTTAAATATCGCTGAGGTCGCAAAAAGAGCTGGTGTATCCACCGCAACGGTTTCAAGGGTTTTAAATAACTCGCC
TTTAGTTTCCAGAAGGACAAGGGAAAAGGTACTGGAGGTAATCAAAGAACTGGGCTATGTCCCAAACCATGTTGCACGCA
GCCTGCGAAGCAAAAAAACGGGACTGGTTGCTACGATAATACCATATTCAGCAGATTATGTTTTCAACTTCCCATATTTT
TCCATATTTATAAGAGAAGTGACAAAGCGATTAGCGGAAGATGGTTACCACCTACTTTTGACGACAGAAGAACCTGATGA
TGATCCCGTCAGGATATACAGGACCTTTCTCGATAGAAAAATAGTCGATGGATTCATAATACTCGACCTTAAAGAAAACG
ATGAGAGAGTCAAATTTTTGAAAGACAGAATGGCGAAATTCGTTGTGGTAGGTAGAGCAAAAGATTGTGACGATCTTCCT
TCGGTCGATACCGACAACATGAGCGGTGCCTATAAAGCTACCTCTTATCTCCTTGATAGAGGGTGTAGAAGAGTTCTTTT
TATCAATGGTCCAAAGGAACATAGCGTTTCTATATGGCGTAAAGAAGGGTACAAAGCAGCATATAAGAAAAAGGGTTTAA
AAATTGAGAAATCGCTTATTCTCAACGGTGATTTTATGGAAACATCGGGCTACGAGCTCGTTAAGAACTTTCGTGGAAGA
TTTGATGCTATATTTGCTGCCTCTGACCTGATGGCAATAGGTGCATTAAAAGCGTTAAAAGAAATGAACAGGATCGTACC
CGTAATGGGGTTTGATGATATTCCTCAAGCGAGTATGGTTACTCCCACACTCTCAACAATAAGGCAACCTATCGACAGAG
TGGGTTACGAAGTTGCGGATTCCATTGTTTCATATCTGGAAAAAGGAGAAAAAATATCGAAAGTTCTTGATGTCGAACTA
ATAATTAGAGAATCTACGGAGGTTGATTAG

Upstream 100 bases:

>100_bases
AGATTAAAAAGTTGTGATTGATTTTAGGGATTCACTTCTTAGTTGATATAATGTAATCGATTACAATGTAATCGATTACA
TTCGTATTGGGAGTGAGTTT

Downstream 100 bases:

>100_bases
TTGATTATGAGAATAATAAAGAACGGAAATCTCATGGTTGTGAGCGATGACAATGGATTGATCGATGCCAGAAGTGATAT
AGCTGCGGGTCTGTACCTGG

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MRLNIAEVAKRAGVSTATVSRVLNNSPLVSRRTREKVLEVIKELGYVPNHVARSLRSKKTGLVATIIPYSADYVFNFPYF
SIFIREVTKRLAEDGYHLLLTTEEPDDDPVRIYRTFLDRKIVDGFIILDLKENDERVKFLKDRMAKFVVVGRAKDCDDLP
SVDTDNMSGAYKATSYLLDRGCRRVLFINGPKEHSVSIWRKEGYKAAYKKKGLKIEKSLILNGDFMETSGYELVKNFRGR
FDAIFAASDLMAIGALKALKEMNRIVPVMGFDDIPQASMVTPTLSTIRQPIDRVGYEVADSIVSYLEKGEKISKVLDVEL
IIRESTEVD

Sequences:

>Translated_329_residues
MRLNIAEVAKRAGVSTATVSRVLNNSPLVSRRTREKVLEVIKELGYVPNHVARSLRSKKTGLVATIIPYSADYVFNFPYF
SIFIREVTKRLAEDGYHLLLTTEEPDDDPVRIYRTFLDRKIVDGFIILDLKENDERVKFLKDRMAKFVVVGRAKDCDDLP
SVDTDNMSGAYKATSYLLDRGCRRVLFINGPKEHSVSIWRKEGYKAAYKKKGLKIEKSLILNGDFMETSGYELVKNFRGR
FDAIFAASDLMAIGALKALKEMNRIVPVMGFDDIPQASMVTPTLSTIRQPIDRVGYEVADSIVSYLEKGEKISKVLDVEL
IIRESTEVD
>Mature_329_residues
MRLNIAEVAKRAGVSTATVSRVLNNSPLVSRRTREKVLEVIKELGYVPNHVARSLRSKKTGLVATIIPYSADYVFNFPYF
SIFIREVTKRLAEDGYHLLLTTEEPDDDPVRIYRTFLDRKIVDGFIILDLKENDERVKFLKDRMAKFVVVGRAKDCDDLP
SVDTDNMSGAYKATSYLLDRGCRRVLFINGPKEHSVSIWRKEGYKAAYKKKGLKIEKSLILNGDFMETSGYELVKNFRGR
FDAIFAASDLMAIGALKALKEMNRIVPVMGFDDIPQASMVTPTLSTIRQPIDRVGYEVADSIVSYLEKGEKISKVLDVEL
IIRESTEVD

Specific function: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=303, Percent_Identity=35.3135313531353, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790194, Length=330, Percent_Identity=32.4242424242424, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790369, Length=333, Percent_Identity=29.7297297297297, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789068, Length=351, Percent_Identity=32.7635327635328, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1788474, Length=296, Percent_Identity=31.0810810810811, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787580, Length=308, Percent_Identity=26.2987012987013, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789202, Length=296, Percent_Identity=29.3918918918919, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI48994940, Length=325, Percent_Identity=25.5384615384615, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789456, Length=302, Percent_Identity=29.1390728476821, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787906, Length=332, Percent_Identity=24.6987951807229, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790689, Length=307, Percent_Identity=26.0586319218241, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790715, Length=330, Percent_Identity=22.7272727272727, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786268, Length=211, Percent_Identity=27.9620853080569, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37278; Mature: 37278

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNIAEVAKRAGVSTATVSRVLNNSPLVSRRTREKVLEVIKELGYVPNHVARSLRSKKT
CCCCHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GLVATIIPYSADYVFNFPYFSIFIREVTKRLAEDGYHLLLTTEEPDDDPVRIYRTFLDRK
CEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
IVDGFIILDLKENDERVKFLKDRMAKFVVVGRAKDCDDLPSVDTDNMSGAYKATSYLLDR
HHCCEEEEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GCRRVLFINGPKEHSVSIWRKEGYKAAYKKKGLKIEKSLILNGDFMETSGYELVKNFRGR
CCCEEEEECCCCCCCHHHHHHCCCHHHHHHCCCEEEHHEEECCCCCCCCCHHHHHHHCCH
FDAIFAASDLMAIGALKALKEMNRIVPVMGFDDIPQASMVTPTLSTIRQPIDRVGYEVAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHH
SIVSYLEKGEKISKVLDVELIIRESTEVD
HHHHHHHCCHHHHHHHHHHHEEECCCCCC
>Mature Secondary Structure
MRLNIAEVAKRAGVSTATVSRVLNNSPLVSRRTREKVLEVIKELGYVPNHVARSLRSKKT
CCCCHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GLVATIIPYSADYVFNFPYFSIFIREVTKRLAEDGYHLLLTTEEPDDDPVRIYRTFLDRK
CEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
IVDGFIILDLKENDERVKFLKDRMAKFVVVGRAKDCDDLPSVDTDNMSGAYKATSYLLDR
HHCCEEEEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GCRRVLFINGPKEHSVSIWRKEGYKAAYKKKGLKIEKSLILNGDFMETSGYELVKNFRGR
CCCEEEEECCCCCCCHHHHHHCCCHHHHHHCCCEEEHHEEECCCCCCCCCHHHHHHHCCH
FDAIFAASDLMAIGALKALKEMNRIVPVMGFDDIPQASMVTPTLSTIRQPIDRVGYEVAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHH
SIVSYLEKGEKISKVLDVELIIRESTEVD
HHHHHHHCCHHHHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224066 [H]