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The map label for this gene is proC [H]

Identifier: 239617491

GI number: 239617491

Start: 1175296

End: 1176117

Strand: Direct

Name: proC [H]

Synonym: Kole_1107

Alternate gene names: 239617491

Gene position: 1175296-1176117 (Clockwise)

Preceding gene: 239617490

Following gene: 239617492

Centisome position: 51.05

GC content: 42.46

Gene sequence:

>822_bases
ATGCGTATAGGCATAATTGGTGTAGGAAACATTGGAAGTATCCTTGCCAGAAAGATTCATAATAGATTTTCAATGGACGT
GGGAATGCTTTTTCTGTGCGACCGTTTTCCCGAAAAACTCAGGGATTTTGCCGATAATGATAAAGTTAAAATCTCTGACG
ACCCAGAGAAAGTTTGTGAACAGTCGGATGTGATATTTCTTGCCGTCAAACCTCAAGACGCAGATAACTTGCTATCACAG
ATAGCAAGCATAGACTTTTCGGAAAAAGCGGTTGTGAGCACGATGACGGGAATTTCCGTGTCGACAATTCAGAAAGCGTT
GGATGCAAAAAACGTCGCCAGAATTATGCCAAATATCCCAATAGATATAGGAAAAGGTGTAATCGCGCTTTATTTTTCTG
ATTCCTTTGAGAAAGCCAGAAGGGAACTCATTCTTAAACTTTTGGACCCTCTTGGTACAGTTATTACCGTAAACGAGAAA
GATTTTCCGGCTGTTACGGCGTTGAGTGGTAGCGGCCCGGCGTTCATTTTTGTTATTATAGAGGCATTGATTGACGTTGG
GCTGAAAATGGGGCTTTCGTATGATACTTCTAGAGCACTGATTCTTGATATGATTCTCGGCTCGGTAGAGCTGTTAAAAG
TGAAAGGGAACCATCCTGGTGAGTTCAGGCACATAGTGACTTCTCCCGGAGGGACAACGATCGAAGGGATCTATTCTTTG
GAGCGTGAAGGTCTCAGGGGTACGATTATGAAAGTCCTTTTTGACACCTACTCTCGAGCTATCGATATAAGTAAGAAGGC
TTCAGGTGTAGATAATACATAA

Upstream 100 bases:

>100_bases
ATAACGCTTGAAGGCCCTTCAAAAGAGCTTTTAGCTAACGAAGAGGTTAAAAACGCTTATTTAGGAATTTGAGCTTAAAA
CACTTGAGAGGGTTGAAGAT

Downstream 100 bases:

>100_bases
TTTTTTTCATTTTTCGGACTATTTCCTGTATAATTTCTAATATCCTTGCGCTATTTTCATGGTGCCCTTGTCTTCTGTTT
AATAAGAAGATAAGGGCACC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MRIGIIGVGNIGSILARKIHNRFSMDVGMLFLCDRFPEKLRDFADNDKVKISDDPEKVCEQSDVIFLAVKPQDADNLLSQ
IASIDFSEKAVVSTMTGISVSTIQKALDAKNVARIMPNIPIDIGKGVIALYFSDSFEKARRELILKLLDPLGTVITVNEK
DFPAVTALSGSGPAFIFVIIEALIDVGLKMGLSYDTSRALILDMILGSVELLKVKGNHPGEFRHIVTSPGGTTIEGIYSL
EREGLRGTIMKVLFDTYSRAIDISKKASGVDNT

Sequences:

>Translated_273_residues
MRIGIIGVGNIGSILARKIHNRFSMDVGMLFLCDRFPEKLRDFADNDKVKISDDPEKVCEQSDVIFLAVKPQDADNLLSQ
IASIDFSEKAVVSTMTGISVSTIQKALDAKNVARIMPNIPIDIGKGVIALYFSDSFEKARRELILKLLDPLGTVITVNEK
DFPAVTALSGSGPAFIFVIIEALIDVGLKMGLSYDTSRALILDMILGSVELLKVKGNHPGEFRHIVTSPGGTTIEGIYSL
EREGLRGTIMKVLFDTYSRAIDISKKASGVDNT
>Mature_273_residues
MRIGIIGVGNIGSILARKIHNRFSMDVGMLFLCDRFPEKLRDFADNDKVKISDDPEKVCEQSDVIFLAVKPQDADNLLSQ
IASIDFSEKAVVSTMTGISVSTIQKALDAKNVARIMPNIPIDIGKGVIALYFSDSFEKARRELILKLLDPLGTVITVNEK
DFPAVTALSGSGPAFIFVIIEALIDVGLKMGLSYDTSRALILDMILGSVELLKVKGNHPGEFRHIVTSPGGTTIEGIYSL
EREGLRGTIMKVLFDTYSRAIDISKKASGVDNT

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=27.4436090225564, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797095, Length=223, Percent_Identity=32.7354260089686, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI24797097, Length=223, Percent_Identity=32.7354260089686, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI21361454, Length=278, Percent_Identity=29.136690647482, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=26.7924528301887, Blast_Score=120, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17569021, Length=273, Percent_Identity=33.6996336996337, Blast_Score=141, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=25.7950530035336, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=207, Percent_Identity=29.4685990338164, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=33.8289962825279, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=30.1818181818182, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=36.2573099415205, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29735; Mature: 29735

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGIIGVGNIGSILARKIHNRFSMDVGMLFLCDRFPEKLRDFADNDKVKISDDPEKVCE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHC
QSDVIFLAVKPQDADNLLSQIASIDFSEKAVVSTMTGISVSTIQKALDAKNVARIMPNIP
CCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
IDIGKGVIALYFSDSFEKARRELILKLLDPLGTVITVNEKDFPAVTALSGSGPAFIFVII
EECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCHHHHHH
EALIDVGLKMGLSYDTSRALILDMILGSVELLKVKGNHPGEFRHIVTSPGGTTIEGIYSL
HHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHH
EREGLRGTIMKVLFDTYSRAIDISKKASGVDNT
HHCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure
MRIGIIGVGNIGSILARKIHNRFSMDVGMLFLCDRFPEKLRDFADNDKVKISDDPEKVCE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHC
QSDVIFLAVKPQDADNLLSQIASIDFSEKAVVSTMTGISVSTIQKALDAKNVARIMPNIP
CCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
IDIGKGVIALYFSDSFEKARRELILKLLDPLGTVITVNEKDFPAVTALSGSGPAFIFVII
EECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCHHHHHH
EALIDVGLKMGLSYDTSRALILDMILGSVELLKVKGNHPGEFRHIVTSPGGTTIEGIYSL
HHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHH
EREGLRGTIMKVLFDTYSRAIDISKKASGVDNT
HHCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]