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The map label for this gene is livM [H]

Identifier: 239617488

GI number: 239617488

Start: 1172659

End: 1173726

Strand: Direct

Name: livM [H]

Synonym: Kole_1104

Alternate gene names: 239617488

Gene position: 1172659-1173726 (Clockwise)

Preceding gene: 239617487

Following gene: 239617489

Centisome position: 50.94

GC content: 43.73

Gene sequence:

>1068_bases
ATGTCAGTGAGATTATCTAAGAGAGTTAACTTAATACTGACGATAACATTTTTGCTTTTCATCGCTCTTTTGCTTTACCT
GGCCGACGGGAATCTTAACACCTATTATGTAAGGATTATCTCTCTCATTGGTATATACGGAATAATGGCGGTTAGCCTGA
CTTTAATCAATGGAATCACAGGTATTTTTTCACTGGGACATGCCGGATTTATGGCCATCGGTGCCTACACTTCTGCGCTG
TTGACCATGTCCGTACAACAAAAAGAAATGACTTTCATTCTAGATAAGCTCATCTGGCCGTTCAATTCGATACAGATCCC
ATTTCTTCCGGCAACGTTGATCGGCGGACTTGTAGCTGCTGGTTTTGCTTTCTTAATTGGATGGCCGTCTCTTAGGTTGT
CCGGAGATTACCTTGCGATCACAACATTAGGATTCAGCGAAATAATAAGGATCCTGGCACTCAACCTGAGATCTGTAACA
AATGGTGCTCTCGGGCTTAAGGGTATTCCAACCTACACCAACGTGTGGTGGGCCTGGGGCTGGTTATTTGTTACGGTGTT
GTTCATAGCTAGCTTGGTCAACAGTAGTTATGGAAGAGCATTGAAGGCAATACGTGAAGATCGTGTCGCAGCTGAATCGA
TGGGGATAAACGTTTTCAGGCATCAGTTAATGGCCTTTGTCGTAGGAGGATTTTTTGCCGGTATTGCGGGTTCTCTTTAT
GCCCACTGGTTATCCACAATTGATCCCAGAACAACCACAATAGGAGTCCTACTGACTTTCAACGCTTTGATAATGATAGT
TATAGGCGGTCTCGGCAGTATAAGTGGTGCCATCATTGGTGCAGCTCTTTTCGCTTTCCTGACCGAGTGGCTGAGATTCC
TAGAGGAATCTATAAAGATTTTCTCATTCGAATTCTCCGGTATTCCTGGCATGAGAATGCTGGTACTTTCGGCTCTCTTC
GTAATCGTGATGATCTTCTGGCCACGCGGCATAATGGGAAAAAATGAGTTGACATGGAATAATCTGTACAACTGGATCTT
TAGAAAAAAGGGTGAAGCCAATGAGTAA

Upstream 100 bases:

>100_bases
TGGCTGGTTATAGAGATGCGTTCGCTTTTTTCATACTCATCATTATTCTTTCTTTGAAACCCAATGGTTTACTGGGTAAG
AAAATTATCGTAAAGGTGTG

Downstream 100 bases:

>100_bases
ACTGTTAGAACTTAATCACGTAACCATGAAGTTTGGTGGGCTTGTTGCCGTAAATGATTTCGATAATTACATTGAAGAAG
GAGAAATTCTCGGCTTGATT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSVRLSKRVNLILTITFLLFIALLLYLADGNLNTYYVRIISLIGIYGIMAVSLTLINGITGIFSLGHAGFMAIGAYTSAL
LTMSVQQKEMTFILDKLIWPFNSIQIPFLPATLIGGLVAAGFAFLIGWPSLRLSGDYLAITTLGFSEIIRILALNLRSVT
NGALGLKGIPTYTNVWWAWGWLFVTVLFIASLVNSSYGRALKAIREDRVAAESMGINVFRHQLMAFVVGGFFAGIAGSLY
AHWLSTIDPRTTTIGVLLTFNALIMIVIGGLGSISGAIIGAALFAFLTEWLRFLEESIKIFSFEFSGIPGMRMLVLSALF
VIVMIFWPRGIMGKNELTWNNLYNWIFRKKGEANE

Sequences:

>Translated_355_residues
MSVRLSKRVNLILTITFLLFIALLLYLADGNLNTYYVRIISLIGIYGIMAVSLTLINGITGIFSLGHAGFMAIGAYTSAL
LTMSVQQKEMTFILDKLIWPFNSIQIPFLPATLIGGLVAAGFAFLIGWPSLRLSGDYLAITTLGFSEIIRILALNLRSVT
NGALGLKGIPTYTNVWWAWGWLFVTVLFIASLVNSSYGRALKAIREDRVAAESMGINVFRHQLMAFVVGGFFAGIAGSLY
AHWLSTIDPRTTTIGVLLTFNALIMIVIGGLGSISGAIIGAALFAFLTEWLRFLEESIKIFSFEFSGIPGMRMLVLSALF
VIVMIFWPRGIMGKNELTWNNLYNWIFRKKGEANE
>Mature_354_residues
SVRLSKRVNLILTITFLLFIALLLYLADGNLNTYYVRIISLIGIYGIMAVSLTLINGITGIFSLGHAGFMAIGAYTSALL
TMSVQQKEMTFILDKLIWPFNSIQIPFLPATLIGGLVAAGFAFLIGWPSLRLSGDYLAITTLGFSEIIRILALNLRSVTN
GALGLKGIPTYTNVWWAWGWLFVTVLFIASLVNSSYGRALKAIREDRVAAESMGINVFRHQLMAFVVGGFFAGIAGSLYA
HWLSTIDPRTTTIGVLLTFNALIMIVIGGLGSISGAIIGAALFAFLTEWLRFLEESIKIFSFEFSGIPGMRMLVLSALFV
IVMIFWPRGIMGKNELTWNNLYNWIFRKKGEANE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=341, Percent_Identity=31.9648093841642, Blast_Score=131, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 39139; Mature: 39008

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRLSKRVNLILTITFLLFIALLLYLADGNLNTYYVRIISLIGIYGIMAVSLTLINGIT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFSLGHAGFMAIGAYTSALLTMSVQQKEMTFILDKLIWPFNSIQIPFLPATLIGGLVAA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
GFAFLIGWPSLRLSGDYLAITTLGFSEIIRILALNLRSVTNGALGLKGIPTYTNVWWAWG
HHHHHHCCCCCEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
WLFVTVLFIASLVNSSYGRALKAIREDRVAAESMGINVFRHQLMAFVVGGFFAGIAGSLY
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHWLSTIDPRTTTIGVLLTFNALIMIVIGGLGSISGAIIGAALFAFLTEWLRFLEESIKI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FSFEFSGIPGMRMLVLSALFVIVMIFWPRGIMGKNELTWNNLYNWIFRKKGEANE
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVRLSKRVNLILTITFLLFIALLLYLADGNLNTYYVRIISLIGIYGIMAVSLTLINGIT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFSLGHAGFMAIGAYTSALLTMSVQQKEMTFILDKLIWPFNSIQIPFLPATLIGGLVAA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
GFAFLIGWPSLRLSGDYLAITTLGFSEIIRILALNLRSVTNGALGLKGIPTYTNVWWAWG
HHHHHHCCCCCEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
WLFVTVLFIASLVNSSYGRALKAIREDRVAAESMGINVFRHQLMAFVVGGFFAGIAGSLY
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHWLSTIDPRTTTIGVLLTFNALIMIVIGGLGSISGAIIGAALFAFLTEWLRFLEESIKI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FSFEFSGIPGMRMLVLSALFVIVMIFWPRGIMGKNELTWNNLYNWIFRKKGEANE
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]