Click here to switch to the map view.

The map label for this gene is mutS [H]

Identifier: 239617350

GI number: 239617350

Start: 1015627

End: 1017048

Strand: Reverse

Name: mutS [H]

Synonym: Kole_0960

Alternate gene names: 239617350

Gene position: 1017048-1015627 (Counterclockwise)

Preceding gene: 239617351

Following gene: 239617349

Centisome position: 44.18

GC content: 40.58

Gene sequence:

>1422_bases
GTGATTGAAAGGGATTTTGCGGAAAAGATTGGTTTCACATATATCAAAAACGCTCTCGATATAATCACGCCTATGGGCAG
GAAGCATCTTGAGTCCCTTGAATATCTCACCGATCCTGAAAAGATCGAAGCTGAACTCAGAATTTTTGATGAAATAGCCA
GGTACATCGCCTGTAACCTTTCTCTTAAGGATAATCTCAAGCATAGGTTGTGTCAACTCAGGGATATTTCTGGTGTGGTT
AAGAGATTGGGAACAGGTGAAACCTTCGATGATATCGCACTTTTTGAAATAAAGGCGTTCTGTATTGAAGCGGAAGAACT
TCGAAGGTTGCTTGTTACCCCGCCGAAGTCGATTGAAATTCCAGAGCTTTCGGAAGTTATCAGACTTCTGGATCCTGAAG
GGTTCGGAATGAAAAGTTTTTACATATACGATGCTTATTCCGTCGAACTTGCTGCTTTAAGGAAAAGAAAGCGGGAGTTA
GAGGGACTTTCAGATGGTGATGATGTTCAGGTAAACGAGGAACTTAACGATTTGATTAACAGGATAGGAGATATTGAAGA
TCGCATCCGAACAATGCTTACAGAGAGGCTTTCAAAATATCGTGAGCTTCTCGAAGAAGCGCTTGAAAAGGTTGGATTTT
TAGATTTTTCTCTTGCAAAGCTGGAGATCATAGAGAAGTTTGGTTTCATTAGACCCACTGTTTCTGATAGTGTAACAGAA
TATGTGGGGTTGTTTGAGCCACAGGTTAGCGATGAACTGAAGAAAAAGGGAAAAGAATTTCAACCTGTTGATATACAGCT
ACAACCCGGAGTAACTCTTATAACCGGTGCTAATATGACTGGTAAAACCGTTCTATTGCGTTCCCTTGCTGTCGCTCAAG
TGTTGTTTCAATTTGGTTTCTATGTTCCGGCGAAGAGGGCAAAAATAAAGCCTGTTGATGGGGTTTTCTTTTTATCGGGG
GATTATCAGTCTTTCAAACACGGGTTATCTTCATTTGCCGCTGAAATGATTCAGTTGAACACAGCGGTAGAATTTTTAAA
GGTGGGGAAAAGAGGATTATTTCTTTTTGACGAGTTAGCAAGGAACACGAACCCCCACGAGGGGAAAGCCATTGTAAAAT
CAGTTTTGAGAAGATTTAATTCATCGAAATCTTTCACAGTTATTACCACGCATTATGATGGAGTTTCCAGAGGTGAAAAC
GTACACCATTATATGGTAAAAGGATTGAGAGAAGATATTGATGTTAGTGGTGAAGTCAAACCAGAAACACTTACGGAATA
CACCGATTATTCACTTGTTAAGGTGAAAGGGGAATATCAGGTACCACGCGAAGCTTTGAAAGTGGCAACTCTTTTGGGAG
TCGATCCCGTCATTATAGAAACTGCCAGGGAATTACTAGACGAAGAAACAGAGTTACATTAG

Upstream 100 bases:

>100_bases
CTCCAAAGGGCTACAAGCTCAATTCGGAAGAGCTTGTAGGGCTTCTGGAGAAGGAACTGGGAGTACCGGTTATCGATGTC
GTTGAAGAAGGTGATTTGAC

Downstream 100 bases:

>100_bases
ATTGAATAAATGAATGAAATAGATCAGGGAGGCTTGAGATTATGAAAAGTAAGCTTGGTCTAGATTTTAAGAAAGTTGAA
TATGCCAGGAACCTTGCGAA

Product: DNA mismatch repair protein MutS domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MIERDFAEKIGFTYIKNALDIITPMGRKHLESLEYLTDPEKIEAELRIFDEIARYIACNLSLKDNLKHRLCQLRDISGVV
KRLGTGETFDDIALFEIKAFCIEAEELRRLLVTPPKSIEIPELSEVIRLLDPEGFGMKSFYIYDAYSVELAALRKRKREL
EGLSDGDDVQVNEELNDLINRIGDIEDRIRTMLTERLSKYRELLEEALEKVGFLDFSLAKLEIIEKFGFIRPTVSDSVTE
YVGLFEPQVSDELKKKGKEFQPVDIQLQPGVTLITGANMTGKTVLLRSLAVAQVLFQFGFYVPAKRAKIKPVDGVFFLSG
DYQSFKHGLSSFAAEMIQLNTAVEFLKVGKRGLFLFDELARNTNPHEGKAIVKSVLRRFNSSKSFTVITTHYDGVSRGEN
VHHYMVKGLREDIDVSGEVKPETLTEYTDYSLVKVKGEYQVPREALKVATLLGVDPVIIETARELLDEETELH

Sequences:

>Translated_473_residues
MIERDFAEKIGFTYIKNALDIITPMGRKHLESLEYLTDPEKIEAELRIFDEIARYIACNLSLKDNLKHRLCQLRDISGVV
KRLGTGETFDDIALFEIKAFCIEAEELRRLLVTPPKSIEIPELSEVIRLLDPEGFGMKSFYIYDAYSVELAALRKRKREL
EGLSDGDDVQVNEELNDLINRIGDIEDRIRTMLTERLSKYRELLEEALEKVGFLDFSLAKLEIIEKFGFIRPTVSDSVTE
YVGLFEPQVSDELKKKGKEFQPVDIQLQPGVTLITGANMTGKTVLLRSLAVAQVLFQFGFYVPAKRAKIKPVDGVFFLSG
DYQSFKHGLSSFAAEMIQLNTAVEFLKVGKRGLFLFDELARNTNPHEGKAIVKSVLRRFNSSKSFTVITTHYDGVSRGEN
VHHYMVKGLREDIDVSGEVKPETLTEYTDYSLVKVKGEYQVPREALKVATLLGVDPVIIETARELLDEETELH
>Mature_473_residues
MIERDFAEKIGFTYIKNALDIITPMGRKHLESLEYLTDPEKIEAELRIFDEIARYIACNLSLKDNLKHRLCQLRDISGVV
KRLGTGETFDDIALFEIKAFCIEAEELRRLLVTPPKSIEIPELSEVIRLLDPEGFGMKSFYIYDAYSVELAALRKRKREL
EGLSDGDDVQVNEELNDLINRIGDIEDRIRTMLTERLSKYRELLEEALEKVGFLDFSLAKLEIIEKFGFIRPTVSDSVTE
YVGLFEPQVSDELKKKGKEFQPVDIQLQPGVTLITGANMTGKTVLLRSLAVAQVLFQFGFYVPAKRAKIKPVDGVFFLSG
DYQSFKHGLSSFAAEMIQLNTAVEFLKVGKRGLFLFDELARNTNPHEGKAIVKSVLRRFNSSKSFTVITTHYDGVSRGEN
VHHYMVKGLREDIDVSGEVKPETLTEYTDYSLVKVKGEYQVPREALKVATLLGVDPVIIETARELLDEETELH

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=218, Percent_Identity=31.651376146789, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI36949366, Length=240, Percent_Identity=24.1666666666667, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4504191, Length=244, Percent_Identity=27.4590163934426, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI26638666, Length=275, Percent_Identity=25.4545454545455, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4505253, Length=275, Percent_Identity=25.4545454545455, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI26638664, Length=277, Percent_Identity=25.9927797833935, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI262231786, Length=277, Percent_Identity=25.9927797833935, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789089, Length=136, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508445, Length=213, Percent_Identity=29.5774647887324, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=220, Percent_Identity=29.5454545454545, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534743, Length=200, Percent_Identity=26, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320302, Length=299, Percent_Identity=26.7558528428094, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319935, Length=140, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=201, Percent_Identity=27.363184079602, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=198, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24584320, Length=203, Percent_Identity=25.615763546798, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664545, Length=235, Percent_Identity=26.3829787234043, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 53777; Mature: 53777

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERDFAEKIGFTYIKNALDIITPMGRKHLESLEYLTDPEKIEAELRIFDEIARYIACNL
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
SLKDNLKHRLCQLRDISGVVKRLGTGETFDDIALFEIKAFCIEAEELRRLLVTPPKSIEI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
PELSEVIRLLDPEGFGMKSFYIYDAYSVELAALRKRKRELEGLSDGDDVQVNEELNDLIN
CCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHH
RIGDIEDRIRTMLTERLSKYRELLEEALEKVGFLDFSLAKLEIIEKFGFIRPTVSDSVTE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
YVGLFEPQVSDELKKKGKEFQPVDIQLQPGVTLITGANMTGKTVLLRSLAVAQVLFQFGF
HHHCCCCCHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
YVPAKRAKIKPVDGVFFLSGDYQSFKHGLSSFAAEMIQLNTAVEFLKVGKRGLFLFDELA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RNTNPHEGKAIVKSVLRRFNSSKSFTVITTHYDGVSRGENVHHYMVKGLREDIDVSGEVK
CCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCC
PETLTEYTDYSLVKVKGEYQVPREALKVATLLGVDPVIIETARELLDEETELH
CHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIERDFAEKIGFTYIKNALDIITPMGRKHLESLEYLTDPEKIEAELRIFDEIARYIACNL
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
SLKDNLKHRLCQLRDISGVVKRLGTGETFDDIALFEIKAFCIEAEELRRLLVTPPKSIEI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
PELSEVIRLLDPEGFGMKSFYIYDAYSVELAALRKRKRELEGLSDGDDVQVNEELNDLIN
CCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHH
RIGDIEDRIRTMLTERLSKYRELLEEALEKVGFLDFSLAKLEIIEKFGFIRPTVSDSVTE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
YVGLFEPQVSDELKKKGKEFQPVDIQLQPGVTLITGANMTGKTVLLRSLAVAQVLFQFGF
HHHCCCCCHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
YVPAKRAKIKPVDGVFFLSGDYQSFKHGLSSFAAEMIQLNTAVEFLKVGKRGLFLFDELA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RNTNPHEGKAIVKSVLRRFNSSKSFTVITTHYDGVSRGENVHHYMVKGLREDIDVSGEVK
CCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCC
PETLTEYTDYSLVKVKGEYQVPREALKVATLLGVDPVIIETARELLDEETELH
CHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA