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The map label for this gene is hgdA [H]

Identifier: 239617337

GI number: 239617337

Start: 1000570

End: 1001826

Strand: Reverse

Name: hgdA [H]

Synonym: Kole_0946

Alternate gene names: 239617337

Gene position: 1001826-1000570 (Counterclockwise)

Preceding gene: 239617348

Following gene: 239617336

Centisome position: 43.52

GC content: 43.68

Gene sequence:

>1257_bases
ATGTCAAAATCGAGTAGATTGTTCGGAAAGTTCTTAAGCAATTACCTAGATCAGCCCGAAAAATTCAGAAGGTATCTGAG
TATGGGATTAAGTTTCGAACTCTTCAAAAGAAAAAATTTTCCGGATAAGAAGAAACCTTCTTTTGTTGCCAGTATAAATC
ACCTTGCCGTTTATGAGGTATATCAGGCGGTAAGAGGAAACAACAGCGTCTGGGTGAATCTTCTCGCGCCTTCTGAAATA
CTGATAGCTGCAGGTTTGAACCCCGTTTCAGCTGAGGGCATAGCCGGAACGATGTCAGCCATGCACCTCGAGGGGTACGC
AATAGAGTTGAGCATGAGCGAAGGAGTAACGCCCTCTCTTTGCACGTTTCATCGGTGCTCGTTGGGAACAGCAATTTGGA
AAAGTTTTCCAAAGCCGTTGTTTACAATGACCACATCGGTTTTATGCGACGGAAATGCAGGAACGTTTCATTCGATAGCA
AAGGCTTACGGGGTCCCCTTTTTCATGATAGATGTCCCGCGCGGTCGAAAAAGGGAATACGTTCCCTATGTTGAGAAACA
ACTTCGTGAGCTCATAACCTTCGTGGAAGAGATCACAGGACAAACTTACAATATGAACAGGCTCTCAGAAATCCTCGAAA
TAGAAGAAGAAACAAGGAAGAATCTTCTTCAAGCGAGAAAAAAGCTCGCTGAAAAGGTTATTCCCTTCGAGGTGTATGAA
CATATGAACACGCTTTACGTTCTCCACACTTTGGTAGGTGATGAAAGGTTGCTGGAAGCTTCAAATAGATTCCTTTCAGA
TTTTGATAGAGAATGGCAGGATCCTGAGAAGAGAGTTCTCTGGCTTCATATACCGCCTTACTACGACAACGAACTTTTCG
AGCTGTTTTCACCTTATGGTAAGGTATCAGTTGTTAGTTCAGAACTCTGGTGGGACTGGGTGTATCCTTTGAATCCAAAG
GATCCCATAAGGAGTCTCGCTGAAAAACTGGTATTCAACATAGAAAATGGGACGGTAGAAGAAAGAGGGAATTTTCTCAT
AAAGCTTAGCGAGGAATTGAAAGTAGATGCTGTGGTTCATTTTTCTCATTGGGGATGCCGCCAATCAAGTGGAGCGGTTG
GGTATCTTAAGAAGCAGTTCATCGAGAAAGAGATACCCTTCCTGTCCCTGGATGGAGACTGTGTGGATCATACGGCAGAA
AGTGCCGGACAATTTAGTACAAGGGTAAAAGCTTTCTTTGAGATGTTGGGGGTATAG

Upstream 100 bases:

>100_bases
AGGCAGATGATATCGTGTATGATTTTAATATATAGAGTATTAATGCAGACTTTCCTGAAGATATCGAAAGTGCGGGTATT
ACCGAACTCGGGAGGTGCTT

Downstream 100 bases:

>100_bases
GAAGATGATATATTACGCATGTACTTACGTACCGGTTGAAATTCTGATTGCTTCAGGGTTACCTTTCCAGAAGCTGGAGG
TCAGAGAATCCGGAGAGGAT

Product: 2-hydroxyglutaryl-CoA dehydratase D-component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSKSSRLFGKFLSNYLDQPEKFRRYLSMGLSFELFKRKNFPDKKKPSFVASINHLAVYEVYQAVRGNNSVWVNLLAPSEI
LIAAGLNPVSAEGIAGTMSAMHLEGYAIELSMSEGVTPSLCTFHRCSLGTAIWKSFPKPLFTMTTSVLCDGNAGTFHSIA
KAYGVPFFMIDVPRGRKREYVPYVEKQLRELITFVEEITGQTYNMNRLSEILEIEEETRKNLLQARKKLAEKVIPFEVYE
HMNTLYVLHTLVGDERLLEASNRFLSDFDREWQDPEKRVLWLHIPPYYDNELFELFSPYGKVSVVSSELWWDWVYPLNPK
DPIRSLAEKLVFNIENGTVEERGNFLIKLSEELKVDAVVHFSHWGCRQSSGAVGYLKKQFIEKEIPFLSLDGDCVDHTAE
SAGQFSTRVKAFFEMLGV

Sequences:

>Translated_418_residues
MSKSSRLFGKFLSNYLDQPEKFRRYLSMGLSFELFKRKNFPDKKKPSFVASINHLAVYEVYQAVRGNNSVWVNLLAPSEI
LIAAGLNPVSAEGIAGTMSAMHLEGYAIELSMSEGVTPSLCTFHRCSLGTAIWKSFPKPLFTMTTSVLCDGNAGTFHSIA
KAYGVPFFMIDVPRGRKREYVPYVEKQLRELITFVEEITGQTYNMNRLSEILEIEEETRKNLLQARKKLAEKVIPFEVYE
HMNTLYVLHTLVGDERLLEASNRFLSDFDREWQDPEKRVLWLHIPPYYDNELFELFSPYGKVSVVSSELWWDWVYPLNPK
DPIRSLAEKLVFNIENGTVEERGNFLIKLSEELKVDAVVHFSHWGCRQSSGAVGYLKKQFIEKEIPFLSLDGDCVDHTAE
SAGQFSTRVKAFFEMLGV
>Mature_417_residues
SKSSRLFGKFLSNYLDQPEKFRRYLSMGLSFELFKRKNFPDKKKPSFVASINHLAVYEVYQAVRGNNSVWVNLLAPSEIL
IAAGLNPVSAEGIAGTMSAMHLEGYAIELSMSEGVTPSLCTFHRCSLGTAIWKSFPKPLFTMTTSVLCDGNAGTFHSIAK
AYGVPFFMIDVPRGRKREYVPYVEKQLRELITFVEEITGQTYNMNRLSEILEIEEETRKNLLQARKKLAEKVIPFEVYEH
MNTLYVLHTLVGDERLLEASNRFLSDFDREWQDPEKRVLWLHIPPYYDNELFELFSPYGKVSVVSSELWWDWVYPLNPKD
PIRSLAEKLVFNIENGTVEERGNFLIKLSEELKVDAVVHFSHWGCRQSSGAVGYLKKQFIEKEIPFLSLDGDCVDHTAES
AGQFSTRVKAFFEMLGV

Specific function: Catalyzes the reversible dehydration of 2- hydroxyglutaryl-CoA to glutaconyl-CoA. This is a key step in the fermentation of glutamate. It is activated by hgdC [H]

COG id: COG1775

COG function: function code E; Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010327 [H]

Pfam domain/function: PF06050 HGD-D [H]

EC number: NA

Molecular weight: Translated: 47912; Mature: 47781

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSSRLFGKFLSNYLDQPEKFRRYLSMGLSFELFKRKNFPDKKKPSFVASINHLAVYEV
CCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YQAVRGNNSVWVNLLAPSEILIAAGLNPVSAEGIAGTMSAMHLEGYAIELSMSEGVTPSL
HHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHEECCEEEEEECCCCCCCHH
CTFHRCSLGTAIWKSFPKPLFTMTTSVLCDGNAGTFHSIAKAYGVPFFMIDVPRGRKREY
HHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
VPYVEKQLRELITFVEEITGQTYNMNRLSEILEIEEETRKNLLQARKKLAEKVIPFEVYE
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HMNTLYVLHTLVGDERLLEASNRFLSDFDREWQDPEKRVLWLHIPPYYDNELFELFSPYG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCC
KVSVVSSELWWDWVYPLNPKDPIRSLAEKLVFNIENGTVEERGNFLIKLSEELKVDAVVH
CEEEEEHHHCEEEECCCCCHHHHHHHHHHHEEECCCCCHHCCCCEEEEECCCCCEEEEEE
FSHWGCRQSSGAVGYLKKQFIEKEIPFLSLDGDCVDHTAESAGQFSTRVKAFFEMLGV
ECCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKSSRLFGKFLSNYLDQPEKFRRYLSMGLSFELFKRKNFPDKKKPSFVASINHLAVYEV
CCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YQAVRGNNSVWVNLLAPSEILIAAGLNPVSAEGIAGTMSAMHLEGYAIELSMSEGVTPSL
HHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHEECCEEEEEECCCCCCCHH
CTFHRCSLGTAIWKSFPKPLFTMTTSVLCDGNAGTFHSIAKAYGVPFFMIDVPRGRKREY
HHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
VPYVEKQLRELITFVEEITGQTYNMNRLSEILEIEEETRKNLLQARKKLAEKVIPFEVYE
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HMNTLYVLHTLVGDERLLEASNRFLSDFDREWQDPEKRVLWLHIPPYYDNELFELFSPYG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCC
KVSVVSSELWWDWVYPLNPKDPIRSLAEKLVFNIENGTVEERGNFLIKLSEELKVDAVVH
CEEEEEHHHCEEEECCCCCHHHHHHHHHHHEEECCCCCHHCCCCEEEEECCCCCEEEEEE
FSHWGCRQSSGAVGYLKKQFIEKEIPFLSLDGDCVDHTAESAGQFSTRVKAFFEMLGV
ECCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659350; 3691501; 8365476; 11106419 [H]