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The map label for this gene is ndk

Identifier: 239617287

GI number: 239617287

Start: 948729

End: 949172

Strand: Direct

Name: ndk

Synonym: Kole_0896

Alternate gene names: 239617287

Gene position: 948729-949172 (Clockwise)

Preceding gene: 239617279

Following gene: 239617288

Centisome position: 41.21

GC content: 43.92

Gene sequence:

>444_bases
ATGGAGAGAACATTTGTTTATTTGAAACCAAATACGATACAGAGGCAATTGATCGGGGAAGTGATATCCAGATTTGAAAG
GAAAGGGCTGAAAATCGTAGCTTTAAAAATGCTGAAAATGACAATGGAGCAGGCGGAGAAACTCTACGAGGAACACAAAG
GGAAGGATTTCTATAAGCCGCTTCTGAAGTTTGTTACCTCCGGTCCAATAGTTGCGATGATCCTTGAGGGACCCCGGGCT
GTTGAGGTTGTTCGCCATGTTATAGGAAAAACGGATCCTCTTGAAGCTAACAGCGGGACGATCAGGGGAGAATTCGGAGT
CACGATAAGAAAGAACATAGTCCATGCTTCCGACAGTCCCGAGCATGCCAAACACGAAATGTCGATTTTCTTCGATACCA
GTGAAATCGTGGATTATAAGCTCTTACTAGAGGAACAATTCTGA

Upstream 100 bases:

>100_bases
TGTTTTTAGAAAGGTCTCATTCATAACTCCCATAATTTAATTATAGCTGAAAGCTAGCAAATGTTATATGTATGATATAT
TTTTAAATGGGAGGGATTTT

Downstream 100 bases:

>100_bases
TGGTCATAGCTGTTTTAAAAAAAGGAAAGGAAAAGAAGCTCCTCAACGGTTACCCGTGGGTTTTTGAAGATGAAATCAGT
GAAGTTCAGGGTGAGCTAAT

Product: Nucleoside-diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MERTFVYLKPNTIQRQLIGEVISRFERKGLKIVALKMLKMTMEQAEKLYEEHKGKDFYKPLLKFVTSGPIVAMILEGPRA
VEVVRHVIGKTDPLEANSGTIRGEFGVTIRKNIVHASDSPEHAKHEMSIFFDTSEIVDYKLLLEEQF

Sequences:

>Translated_147_residues
MERTFVYLKPNTIQRQLIGEVISRFERKGLKIVALKMLKMTMEQAEKLYEEHKGKDFYKPLLKFVTSGPIVAMILEGPRA
VEVVRHVIGKTDPLEANSGTIRGEFGVTIRKNIVHASDSPEHAKHEMSIFFDTSEIVDYKLLLEEQF
>Mature_147_residues
MERTFVYLKPNTIQRQLIGEVISRFERKGLKIVALKMLKMTMEQAEKLYEEHKGKDFYKPLLKFVTSGPIVAMILEGPRA
VEVVRHVIGKTDPLEANSGTIRGEFGVTIRKNIVHASDSPEHAKHEMSIFFDTSEIVDYKLLLEEQF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=140, Percent_Identity=43.5714285714286, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI66392205, Length=140, Percent_Identity=43.5714285714286, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI4505409, Length=140, Percent_Identity=43.5714285714286, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI66392192, Length=140, Percent_Identity=43.5714285714286, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=45.6521739130435, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI66392203, Length=140, Percent_Identity=43.5714285714286, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI37693993, Length=139, Percent_Identity=43.1654676258993, Blast_Score=137, Evalue=2e-33,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=41.726618705036, Blast_Score=132, Evalue=8e-32,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=41.726618705036, Blast_Score=132, Evalue=9e-32,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=35, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI5031951, Length=145, Percent_Identity=33.7931034482759, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI7019465, Length=140, Percent_Identity=31.4285714285714, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI37574614, Length=140, Percent_Identity=31.4285714285714, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=44.5255474452555, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=138, Percent_Identity=40.5797101449275, Blast_Score=125, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71995094, Length=130, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322783, Length=138, Percent_Identity=42.7536231884058, Blast_Score=136, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45549037, Length=138, Percent_Identity=40.5797101449275, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_KOSOT (C5CGM3)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002940609.1
- GeneID:   7967437
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_0896
- ProtClustDB:   CLSK975798
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16892; Mature: 16892

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFVYLKPNTIQRQLIGEVISRFERKGLKIVALKMLKMTMEQAEKLYEEHKGKDFYKP
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LLKFVTSGPIVAMILEGPRAVEVVRHVIGKTDPLEANSGTIRGEFGVTIRKNIVHASDSP
HHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCC
EHAKHEMSIFFDTSEIVDYKLLLEEQF
CHHHHHEEEEECHHHHHHHHHEEECCC
>Mature Secondary Structure
MERTFVYLKPNTIQRQLIGEVISRFERKGLKIVALKMLKMTMEQAEKLYEEHKGKDFYKP
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LLKFVTSGPIVAMILEGPRAVEVVRHVIGKTDPLEANSGTIRGEFGVTIRKNIVHASDSP
HHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCC
EHAKHEMSIFFDTSEIVDYKLLLEEQF
CHHHHHEEEEECHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA