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The map label for this gene is hemN [H]

Identifier: 239617122

GI number: 239617122

Start: 776124

End: 777344

Strand: Direct

Name: hemN [H]

Synonym: Kole_0725

Alternate gene names: 239617122

Gene position: 776124-777344 (Clockwise)

Preceding gene: 239617119

Following gene: 239617126

Centisome position: 33.71

GC content: 38.66

Gene sequence:

>1221_bases
ATGGTTGAACTACTTAAGCTGTACGTTAAGTCGAAAGCTAAACCTTCAAAAAATACAGAATTGATGGGATATATTTTTCC
TTCCGAAAATATTGGTTTGTACCTCCATGTACCTTTTTGTAAGCACTTTTGCGATTTTTGTCCTTATCATAAGTTGAAGT
ATGATCCTGCTCTTGCTAGAGAGTATGCGGGATTAGTCAAAAAAGAATACCGGCTTCACGAACCTAGAAGATTTAACTCG
CTTTATATAGGTGGTGGTACTCCTTCGGGAGACCTGACTCTTTTGAAGGAATTACTGGATTTTCTCAGGGATAACGTTAT
GGGTGAAATCGCGCTGGAGGTGCATCCCATTGACGCAACTTCAGAAAAACTGCAAGAGATGAAAGAATTGGGGATTAATT
ACATTAGTCTAGGCATTCAATCGTTGGATGATGATGTTTTGAAACATTTCGGTAGAGGATACAGTGCAAAAACCAATTTT
CTAGCTTTAGAAAATAGCATTAAAGCAGGTTTTGATTTTGTGGATGTGGATTTAGTCTTCGATCCGTTGGCTTTTGCAGA
TAAAAAGATCCAATCTGATCTGGAGAAGATTATGAAACTTTCGCCACAGCAGATTTCCGTTTATCCTATGATGCGTTTTT
CCTGTACCAAATTCAGAAACACGCGGAACAACAGCAGAAAAGAATTGAAAATTTTCGATAGGTTAGACGAAATCGCAGAC
AAGAATGGTTATGAGCGGGATACTCTCTGGACTTATAAAAAGAAAAATTTGGTTGGAAGATACACTTCTGTCGCGAGAGA
GTTCTACCTTGGTCTTGGGCTAAGCGCTTCAACTTTTTCGGGGGAGATTTTTGCGGTAAATACCTTTTCAATGAACCTCT
ACAGAAAAAGGCTTGAAGAAGGAAAACTTCCGATTGAAATTGTGTACCATTTGAAAGGCTTACAGGGAGCACTATATTAC
TCTTTTTGGGCTTTTTATGCAGGAAAACTGGATTTTGCCAGATTGTCCAGATTCTTTCCTGATTCGTCTAAAAAGCTTCG
AGTTTTGTTTGAAACGCTTCGATTGACGGGGTACCTGTCAAAAAGCAGTATGATCTACCATCTCACTCCACGTGGTCAAA
AAAAGCTTCATCAATTTGAAGAATGGTTAACGTATGCGTTTATAGACCCAATATGGTGTCAGCTGAAAGAGAACGCCAGA
AACTTTAAGGACTTATTTTAA

Upstream 100 bases:

>100_bases
AATCAAGCAAGCTGTTGGGCTTCATTACACGGTGAATGCTTACTATAAGGTATAATATGGATAACTACACTGAACTATTT
ATAAAGAGGAAGAATTCCCT

Downstream 100 bases:

>100_bases
TTATTACCAAACTCTCATTCCGATCAATCTCAGTTTTTTCTCAGATAATGTATCGCTATCTGTTCTATCGGAAACGGCAA
CAAGCATATTGAGATATTCG

Product: Coproporphyrinogen dehydrogenase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVELLKLYVKSKAKPSKNTELMGYIFPSENIGLYLHVPFCKHFCDFCPYHKLKYDPALAREYAGLVKKEYRLHEPRRFNS
LYIGGGTPSGDLTLLKELLDFLRDNVMGEIALEVHPIDATSEKLQEMKELGINYISLGIQSLDDDVLKHFGRGYSAKTNF
LALENSIKAGFDFVDVDLVFDPLAFADKKIQSDLEKIMKLSPQQISVYPMMRFSCTKFRNTRNNSRKELKIFDRLDEIAD
KNGYERDTLWTYKKKNLVGRYTSVAREFYLGLGLSASTFSGEIFAVNTFSMNLYRKRLEEGKLPIEIVYHLKGLQGALYY
SFWAFYAGKLDFARLSRFFPDSSKKLRVLFETLRLTGYLSKSSMIYHLTPRGQKKLHQFEEWLTYAFIDPIWCQLKENAR
NFKDLF

Sequences:

>Translated_406_residues
MVELLKLYVKSKAKPSKNTELMGYIFPSENIGLYLHVPFCKHFCDFCPYHKLKYDPALAREYAGLVKKEYRLHEPRRFNS
LYIGGGTPSGDLTLLKELLDFLRDNVMGEIALEVHPIDATSEKLQEMKELGINYISLGIQSLDDDVLKHFGRGYSAKTNF
LALENSIKAGFDFVDVDLVFDPLAFADKKIQSDLEKIMKLSPQQISVYPMMRFSCTKFRNTRNNSRKELKIFDRLDEIAD
KNGYERDTLWTYKKKNLVGRYTSVAREFYLGLGLSASTFSGEIFAVNTFSMNLYRKRLEEGKLPIEIVYHLKGLQGALYY
SFWAFYAGKLDFARLSRFFPDSSKKLRVLFETLRLTGYLSKSSMIYHLTPRGQKKLHQFEEWLTYAFIDPIWCQLKENAR
NFKDLF
>Mature_406_residues
MVELLKLYVKSKAKPSKNTELMGYIFPSENIGLYLHVPFCKHFCDFCPYHKLKYDPALAREYAGLVKKEYRLHEPRRFNS
LYIGGGTPSGDLTLLKELLDFLRDNVMGEIALEVHPIDATSEKLQEMKELGINYISLGIQSLDDDVLKHFGRGYSAKTNF
LALENSIKAGFDFVDVDLVFDPLAFADKKIQSDLEKIMKLSPQQISVYPMMRFSCTKFRNTRNNSRKELKIFDRLDEIAD
KNGYERDTLWTYKKKNLVGRYTSVAREFYLGLGLSASTFSGEIFAVNTFSMNLYRKRLEEGKLPIEIVYHLKGLQGALYY
SFWAFYAGKLDFARLSRFFPDSSKKLRVLFETLRLTGYLSKSSMIYHLTPRGQKKLHQFEEWLTYAFIDPIWCQLKENAR
NFKDLF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=187, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI87082341, Length=305, Percent_Identity=23.6065573770492, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789325, Length=269, Percent_Identity=23.7918215613383, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 47252; Mature: 47252

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELLKLYVKSKAKPSKNTELMGYIFPSENIGLYLHVPFCKHFCDFCPYHKLKYDPALAR
CHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHCCCCCCCCCHHHHH
EYAGLVKKEYRLHEPRRFNSLYIGGGTPSGDLTLLKELLDFLRDNVMGEIALEVHPIDAT
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCH
SEKLQEMKELGINYISLGIQSLDDDVLKHFGRGYSAKTNFLALENSIKAGFDFVDVDLVF
HHHHHHHHHHCCCEEEHHHHHCCHHHHHHCCCCCCCCCCEEEEECCHHCCCCEEEEHHEE
DPLAFADKKIQSDLEKIMKLSPQQISVYPMMRFSCTKFRNTRNNSRKELKIFDRLDEIAD
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
KNGYERDTLWTYKKKNLVGRYTSVAREFYLGLGLSASTFSGEIFAVNTFSMNLYRKRLEE
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHHHH
GKLPIEIVYHLKGLQGALYYSFWAFYAGKLDFARLSRFFPDSSKKLRVLFETLRLTGYLS
CCCCEEEEEEHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHEEC
KSSMIYHLTPRGQKKLHQFEEWLTYAFIDPIWCQLKENARNFKDLF
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVELLKLYVKSKAKPSKNTELMGYIFPSENIGLYLHVPFCKHFCDFCPYHKLKYDPALAR
CHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHCCCCCCCCCHHHHH
EYAGLVKKEYRLHEPRRFNSLYIGGGTPSGDLTLLKELLDFLRDNVMGEIALEVHPIDAT
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCH
SEKLQEMKELGINYISLGIQSLDDDVLKHFGRGYSAKTNFLALENSIKAGFDFVDVDLVF
HHHHHHHHHHCCCEEEHHHHHCCHHHHHHCCCCCCCCCCEEEEECCHHCCCCEEEEHHEE
DPLAFADKKIQSDLEKIMKLSPQQISVYPMMRFSCTKFRNTRNNSRKELKIFDRLDEIAD
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
KNGYERDTLWTYKKKNLVGRYTSVAREFYLGLGLSASTFSGEIFAVNTFSMNLYRKRLEE
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHHHH
GKLPIEIVYHLKGLQGALYYSFWAFYAGKLDFARLSRFFPDSSKKLRVLFETLRLTGYLS
CCCCEEEEEEHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHEEC
KSSMIYHLTPRGQKKLHQFEEWLTYAFIDPIWCQLKENARNFKDLF
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]