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The map label for this gene is moeA [C]

Identifier: 239617097

GI number: 239617097

Start: 754030

End: 755262

Strand: Direct

Name: moeA [C]

Synonym: Kole_0699

Alternate gene names: 239617097

Gene position: 754030-755262 (Clockwise)

Preceding gene: 239617096

Following gene: 239617098

Centisome position: 32.75

GC content: 42.42

Gene sequence:

>1233_bases
ATGACTGGAAGATATATGAAGTTCGTTCCTCGAGAAGAAATATATGAGAACTATGTCAAGAAACTCTCACCTATTTCGAC
TGTAGAAATACTGGATGTTCGGGAAGCCTTAGGAAGAATCTGTGCTCAAGACGTTCTTTCTGGAGAAACTTTACCTGGCT
TCAACAAATCCACTTTCGACGGTTACGCAGTGAAGGCAGAGGATACTTTTGGAGCCAGTTTTGAGACTCCGGCGGTGTTA
AAGGTCAAGGGACAGGTGGAGATGGGAAAAGCATTCAAAGGTGAAATTACCTCAGGTGAGGCTGTCAAAATCCCGACAGG
TGGTTTTGTCCCTAATGGAGCCGATGCCTGTGTGATGATTGAAAGTACAAAGGAAATTGGAGATACTGTTGAAATATATG
CAGAGGTTCGGCCTGGGGAAAACCTTGTCAGATACGACGAAGATATACGGGAAGGAGAAATAGTTGTTGAAAAAGGAGAA
AGGATCAATTTTGGACATGTCTATACCCTATTAAGTCTCGGAATAACAACTATAAAAGTTTTCAGAAAAGTTAAAGTAGC
AGTGATTTCTACCGGCGATGAAATAGTCGAACCGGAAAGTGCAAAGGAACTAACCCAGATTAGAGATGGAAACACCCATA
CTCTGGTTTCATGGCTAAATCTTTTTCCTGGAGTAGAAGCCAGAAGGACCGCGCAGATTGTAGATGACCTCAATTCGCTG
ATAAGCAGTATTAAAGAAGCTCTCAAGGACAACGATGTGGTGGTTATTTCTGGAGGAAGCTCCGTCGGTGAAAAGGATTT
TACAACAAAAGCTATTTCTTCATTGGGAGAAGTTAGGTATCACGGTACGTGGATAAAACCCGGAAAACCGACTGTTTTCG
GAGTATGTGATGGTAAACCTGTTCTTGGCTTGCCAGGTAAGCCTTCATCATTTATTGTGAGTAGTTACCTCTTTTTATTC
CCGATTTTAAAACGTTTGGCAGGCCAAAAAGATTTTCTTCCCGTACCTGCCGGGATGGTGAAGATAGAGGATGAAGTCGA
AGCTAAGATGCGACGGGAACGTTTTTTCTTTGTGAAAGTGTTTAAAAAAGATGGGAAAATGTGTGCCACTATAATTCCAG
GACAATCTATGCTGATATCTCCCTTCAGAAAGGCTGATGGAATCATTGCACTGCCTCCCGGTGAAGGAATAAAAGCAGGC
GAAATCCGGGAATATTACAGATTCGATTGGTGA

Upstream 100 bases:

>100_bases
CTCGTGAGGGAATCTTTCTGAGAGTTATTAAAGGCGGCGAGATTTCTGTGGGAGATAGTGTGATTTTCGAAATTTCAGAA
AAGAATGCGGCGGTGATAAA

Downstream 100 bases:

>100_bases
GAACGCTATGAAAAAAACTATCATATTCTTTCTTACAATCGTTTTGATGCTTATCGTAACGGGTTGCAAAAGCAAACGTG
TGGAAATCAATACATTTGAA

Product: molybdenum cofactor synthesis domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTGRYMKFVPREEIYENYVKKLSPISTVEILDVREALGRICAQDVLSGETLPGFNKSTFDGYAVKAEDTFGASFETPAVL
KVKGQVEMGKAFKGEITSGEAVKIPTGGFVPNGADACVMIESTKEIGDTVEIYAEVRPGENLVRYDEDIREGEIVVEKGE
RINFGHVYTLLSLGITTIKVFRKVKVAVISTGDEIVEPESAKELTQIRDGNTHTLVSWLNLFPGVEARRTAQIVDDLNSL
ISSIKEALKDNDVVVISGGSSVGEKDFTTKAISSLGEVRYHGTWIKPGKPTVFGVCDGKPVLGLPGKPSSFIVSSYLFLF
PILKRLAGQKDFLPVPAGMVKIEDEVEAKMRRERFFFVKVFKKDGKMCATIIPGQSMLISPFRKADGIIALPPGEGIKAG
EIREYYRFDW

Sequences:

>Translated_410_residues
MTGRYMKFVPREEIYENYVKKLSPISTVEILDVREALGRICAQDVLSGETLPGFNKSTFDGYAVKAEDTFGASFETPAVL
KVKGQVEMGKAFKGEITSGEAVKIPTGGFVPNGADACVMIESTKEIGDTVEIYAEVRPGENLVRYDEDIREGEIVVEKGE
RINFGHVYTLLSLGITTIKVFRKVKVAVISTGDEIVEPESAKELTQIRDGNTHTLVSWLNLFPGVEARRTAQIVDDLNSL
ISSIKEALKDNDVVVISGGSSVGEKDFTTKAISSLGEVRYHGTWIKPGKPTVFGVCDGKPVLGLPGKPSSFIVSSYLFLF
PILKRLAGQKDFLPVPAGMVKIEDEVEAKMRRERFFFVKVFKKDGKMCATIIPGQSMLISPFRKADGIIALPPGEGIKAG
EIREYYRFDW
>Mature_409_residues
TGRYMKFVPREEIYENYVKKLSPISTVEILDVREALGRICAQDVLSGETLPGFNKSTFDGYAVKAEDTFGASFETPAVLK
VKGQVEMGKAFKGEITSGEAVKIPTGGFVPNGADACVMIESTKEIGDTVEIYAEVRPGENLVRYDEDIREGEIVVEKGER
INFGHVYTLLSLGITTIKVFRKVKVAVISTGDEIVEPESAKELTQIRDGNTHTLVSWLNLFPGVEARRTAQIVDDLNSLI
SSIKEALKDNDVVVISGGSSVGEKDFTTKAISSLGEVRYHGTWIKPGKPTVFGVCDGKPVLGLPGKPSSFIVSSYLFLFP
ILKRLAGQKDFLPVPAGMVKIEDEVEAKMRRERFFFVKVFKKDGKMCATIIPGQSMLISPFRKADGIIALPPGEGIKAGE
IREYYRFDW

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=394, Percent_Identity=30.2030456852792, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI66932975, Length=394, Percent_Identity=30.2030456852792, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1787049, Length=314, Percent_Identity=37.2611464968153, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=310, Percent_Identity=34.5161290322581, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=300, Percent_Identity=25.3333333333333, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17136978, Length=379, Percent_Identity=29.287598944591, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24638841, Length=379, Percent_Identity=29.287598944591, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45111; Mature: 44979

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRYMKFVPREEIYENYVKKLSPISTVEILDVREALGRICAQDVLSGETLPGFNKSTFD
CCCCCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GYAVKAEDTFGASFETPAVLKVKGQVEMGKAFKGEITSGEAVKIPTGGFVPNGADACVMI
CEEEEECCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCEEECCCCCCCCCCCCEEEEE
ESTKEIGDTVEIYAEVRPGENLVRYDEDIREGEIVVEKGERINFGHVYTLLSLGITTIKV
ECCHHCCCEEEEEEEECCCCCHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
FRKVKVAVISTGDEIVEPESAKELTQIRDGNTHTLVSWLNLFPGVEARRTAQIVDDLNSL
HHHEEEEEEECCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ISSIKEALKDNDVVVISGGSSVGEKDFTTKAISSLGEVRYHGTWIKPGKPTVFGVCDGKP
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCEEECCEEECCCCCEEEEEECCCE
VLGLPGKPSSFIVSSYLFLFPILKRLAGQKDFLPVPAGMVKIEDEVEAKMRRERFFFVKV
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHEEEEEE
FKKDGKMCATIIPGQSMLISPFRKADGIIALPPGEGIKAGEIREYYRFDW
EECCCCEEEEEECCCCCEECCHHHCCCEEEECCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TGRYMKFVPREEIYENYVKKLSPISTVEILDVREALGRICAQDVLSGETLPGFNKSTFD
CCCCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GYAVKAEDTFGASFETPAVLKVKGQVEMGKAFKGEITSGEAVKIPTGGFVPNGADACVMI
CEEEEECCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCEEECCCCCCCCCCCCEEEEE
ESTKEIGDTVEIYAEVRPGENLVRYDEDIREGEIVVEKGERINFGHVYTLLSLGITTIKV
ECCHHCCCEEEEEEEECCCCCHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
FRKVKVAVISTGDEIVEPESAKELTQIRDGNTHTLVSWLNLFPGVEARRTAQIVDDLNSL
HHHEEEEEEECCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ISSIKEALKDNDVVVISGGSSVGEKDFTTKAISSLGEVRYHGTWIKPGKPTVFGVCDGKP
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCEEECCEEECCCCCEEEEEECCCE
VLGLPGKPSSFIVSSYLFLFPILKRLAGQKDFLPVPAGMVKIEDEVEAKMRRERFFFVKV
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHEEEEEE
FKKDGKMCATIIPGQSMLISPFRKADGIIALPPGEGIKAGEIREYYRFDW
EECCCCEEEEEECCCCCEECCHHHCCCEEEECCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]