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The map label for this gene is tldD [H]

Identifier: 239616955

GI number: 239616955

Start: 603881

End: 605266

Strand: Direct

Name: tldD [H]

Synonym: Kole_0553

Alternate gene names: 239616955

Gene position: 603881-605266 (Clockwise)

Preceding gene: 239616951

Following gene: 239616956

Centisome position: 26.23

GC content: 44.16

Gene sequence:

>1386_bases
ATGATTGATGGCAGGACAGCAAATGAAGTTATTGGCGTTTTGCTGAAACATGGTGCTGAATTCGTGGAATTATTCATTGA
AGAACGGGATACCAGCAACTTTTCCCTTGTTAATGGACAGCTAGAAAGAGCTCTTTCAGGAAAAACTTTTGGTATAGGTA
TCAGGGCCTTTTCTAAAAACCGTTCTTTATACGCCTTCACCAACGATCTTTCAAAAGAAACGTTAGTACAGATTGCTGCA
AACCTTGGAGAAGTTATCAATGGGAATGGCGAACCACTTTCCCTTGATTTCCGCGAACAATCTATTGAGAACAGGCATCT
CTTTATCCTTGAACCATCCTCTGTATCAAAGACAGACAAAGTCAAGGTAATGAAAATGGCTTTCAATGGTGCCAAAAGCG
TTTCCAAACTCATAACCCAGGTACTTGTGGATTACTGGGATTACGATCAGAGGATTACCATCATAAATTCTGAAGGACTT
AAGGTTTCAGATAGAAGGCTCAGAACAAGACTGATGATTACTGCCGTGGCTTCTAGGTACAATGAAAAAGAGACGGGCTT
TTATGGTCCCGGTGCGGCAATGGGTTTTGAGTTTTTTAACACCTTTGATGTCTTTGAAGCAGGACAAAAAGCCGGGCGTA
TCGCGGCTCGAATGGTCGAAGCTGAATACGCTCCCGCTGGCAGGATGCCGGTAATCATTGCAAACGAATTTGGCGGTGTT
ATCTTTCACGAGGCCTGTGGACATGCCCTTGAAGCAACATCTGTAGCCAAGGGATCTTCAGTATTTACAGGTAAACTAGG
CCAAAAAATAGCGGCCGATTGTGTTTCCGCAGTTGATGACGCTACAATACCGAATGCCTGGGGATCCACGAATATCGATG
ACGAGGGAACACCTACCAGGAGAAACGTGCTCATAGAAAATGGAGTACTGAAGAGTTATCTCATAGACAGGTTCAACGGC
ATAAAAATGGGTATGGAAAGTACAGGGAGCGCCAGAAGGCAGGACTATCGCTATGCTCCTACTTCAAGAATGAGCAATAC
CTTTATACTTCCGGGTCCATACTATCCTGAAGAGATCATTTCAAATACAGAATACGGACTTTATGCAAAATCCTTAGGCG
GGGGCTCGGTAAATACAGGAACGGGAGAATTCAATTTTGCGGTCAGAGAAGGATACCTTATTGAAAAAGGAAGGATCACA
AAACCTGTAAGGGGTGCAACGCTCATTGGAAAAGGCTCTGAGATCCTCATGAAGATTGACATGGTTGGAAATGATCTGAA
ACGCGGTCAGGGAATGTGTGGTTCAGCATCTGGTTTAATACCGGCTGAAGTAGGGCAACCAACCATTAGAGTCTCTGAAT
TGACCGTTGGGGGGCGAAATAGATGA

Upstream 100 bases:

>100_bases
TTTGTTTTGGATATTTTCTTTTTTTCTGTGTTTGTTTTATATTTTTTGGTAAAATAAAAAAGTAAGGAATACTAACCAAT
TAGTTTTTAGGAGGTTTTTT

Downstream 100 bases:

>100_bases
CGTTCGAGAATTTTAAGAAAATGGTTTTTGAGTACGCAGCCGCTAAGAAAACCAATGATTTTGAAATCTACATAAAGAAA
ACACACGAATTTGATGTCAG

Product: peptidase U62 modulator of DNA gyrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MIDGRTANEVIGVLLKHGAEFVELFIEERDTSNFSLVNGQLERALSGKTFGIGIRAFSKNRSLYAFTNDLSKETLVQIAA
NLGEVINGNGEPLSLDFREQSIENRHLFILEPSSVSKTDKVKVMKMAFNGAKSVSKLITQVLVDYWDYDQRITIINSEGL
KVSDRRLRTRLMITAVASRYNEKETGFYGPGAAMGFEFFNTFDVFEAGQKAGRIAARMVEAEYAPAGRMPVIIANEFGGV
IFHEACGHALEATSVAKGSSVFTGKLGQKIAADCVSAVDDATIPNAWGSTNIDDEGTPTRRNVLIENGVLKSYLIDRFNG
IKMGMESTGSARRQDYRYAPTSRMSNTFILPGPYYPEEIISNTEYGLYAKSLGGGSVNTGTGEFNFAVREGYLIEKGRIT
KPVRGATLIGKGSEILMKIDMVGNDLKRGQGMCGSASGLIPAEVGQPTIRVSELTVGGRNR

Sequences:

>Translated_461_residues
MIDGRTANEVIGVLLKHGAEFVELFIEERDTSNFSLVNGQLERALSGKTFGIGIRAFSKNRSLYAFTNDLSKETLVQIAA
NLGEVINGNGEPLSLDFREQSIENRHLFILEPSSVSKTDKVKVMKMAFNGAKSVSKLITQVLVDYWDYDQRITIINSEGL
KVSDRRLRTRLMITAVASRYNEKETGFYGPGAAMGFEFFNTFDVFEAGQKAGRIAARMVEAEYAPAGRMPVIIANEFGGV
IFHEACGHALEATSVAKGSSVFTGKLGQKIAADCVSAVDDATIPNAWGSTNIDDEGTPTRRNVLIENGVLKSYLIDRFNG
IKMGMESTGSARRQDYRYAPTSRMSNTFILPGPYYPEEIISNTEYGLYAKSLGGGSVNTGTGEFNFAVREGYLIEKGRIT
KPVRGATLIGKGSEILMKIDMVGNDLKRGQGMCGSASGLIPAEVGQPTIRVSELTVGGRNR
>Mature_461_residues
MIDGRTANEVIGVLLKHGAEFVELFIEERDTSNFSLVNGQLERALSGKTFGIGIRAFSKNRSLYAFTNDLSKETLVQIAA
NLGEVINGNGEPLSLDFREQSIENRHLFILEPSSVSKTDKVKVMKMAFNGAKSVSKLITQVLVDYWDYDQRITIINSEGL
KVSDRRLRTRLMITAVASRYNEKETGFYGPGAAMGFEFFNTFDVFEAGQKAGRIAARMVEAEYAPAGRMPVIIANEFGGV
IFHEACGHALEATSVAKGSSVFTGKLGQKIAADCVSAVDDATIPNAWGSTNIDDEGTPTRRNVLIENGVLKSYLIDRFNG
IKMGMESTGSARRQDYRYAPTSRMSNTFILPGPYYPEEIISNTEYGLYAKSLGGGSVNTGTGEFNFAVREGYLIEKGRIT
KPVRGATLIGKGSEILMKIDMVGNDLKRGQGMCGSASGLIPAEVGQPTIRVSELTVGGRNR

Specific function: Suppresses the inhibitory activity of the carbon storage regulator (CsrA) [H]

COG id: COG0312

COG function: function code R; Predicted Zn-dependent proteases and their inactivated homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase U62 family [H]

Homologues:

Organism=Escherichia coli, GI1789640, Length=419, Percent_Identity=38.6634844868735, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1790682, Length=400, Percent_Identity=24.5, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002510 [H]

Pfam domain/function: PF01523 PmbA_TldD [H]

EC number: NA

Molecular weight: Translated: 50208; Mature: 50208

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDGRTANEVIGVLLKHGAEFVELFIEERDTSNFSLVNGQLERALSGKTFGIGIRAFSKN
CCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECHHHHHHHCCCEEEEEEEEECCC
RSLYAFTNDLSKETLVQIAANLGEVINGNGEPLSLDFREQSIENRHLFILEPSSVSKTDK
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCEEEEECCCCCCCCHH
VKVMKMAFNGAKSVSKLITQVLVDYWDYDQRITIINSEGLKVSDRRLRTRLMITAVASRY
EEEEEEHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHC
NEKETGFYGPGAAMGFEFFNTFDVFEAGQKAGRIAARMVEAEYAPAGRMPVIIANEFGGV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCE
IFHEACGHALEATSVAKGSSVFTGKLGQKIAADCVSAVDDATIPNAWGSTNIDDEGTPTR
EEHHHCCCHHHHHHHCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
RNVLIENGVLKSYLIDRFNGIKMGMESTGSARRQDYRYAPTSRMSNTFILPGPYYPEEII
HEEEEECCHHHHHHHHHCCCCEECCCCCCCHHHCCCCCCCCCCCCCEEEECCCCCHHHHH
SNTEYGLYAKSLGGGSVNTGTGEFNFAVREGYLIEKGRITKPVRGATLIGKGSEILMKID
CCCCCCEEEECCCCCCCCCCCCCEEEEEECCEEEECCCCCCCCCCEEEEECCCEEEEEEE
MVGNDLKRGQGMCGSASGLIPAEVGQPTIRVSELTVGGRNR
CCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MIDGRTANEVIGVLLKHGAEFVELFIEERDTSNFSLVNGQLERALSGKTFGIGIRAFSKN
CCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECHHHHHHHCCCEEEEEEEEECCC
RSLYAFTNDLSKETLVQIAANLGEVINGNGEPLSLDFREQSIENRHLFILEPSSVSKTDK
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCEEEEECCCCCCCCHH
VKVMKMAFNGAKSVSKLITQVLVDYWDYDQRITIINSEGLKVSDRRLRTRLMITAVASRY
EEEEEEHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHC
NEKETGFYGPGAAMGFEFFNTFDVFEAGQKAGRIAARMVEAEYAPAGRMPVIIANEFGGV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCE
IFHEACGHALEATSVAKGSSVFTGKLGQKIAADCVSAVDDATIPNAWGSTNIDDEGTPTR
EEHHHCCCHHHHHHHCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
RNVLIENGVLKSYLIDRFNGIKMGMESTGSARRQDYRYAPTSRMSNTFILPGPYYPEEII
HEEEEECCHHHHHHHHHCCCCEECCCCCCCHHHCCCCCCCCCCCCCEEEECCCCCHHHHH
SNTEYGLYAKSLGGGSVNTGTGEFNFAVREGYLIEKGRITKPVRGATLIGKGSEILMKID
CCCCCCEEEECCCCCCCCCCCCCEEEEEECCEEEECCCCCCCCCCEEEEECCCEEEEEEE
MVGNDLKRGQGMCGSASGLIPAEVGQPTIRVSELTVGGRNR
CCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]