Click here to switch to the map view.

The map label for this gene is yisQ [H]

Identifier: 239616775

GI number: 239616775

Start: 385838

End: 387172

Strand: Direct

Name: yisQ [H]

Synonym: Kole_0368

Alternate gene names: 239616775

Gene position: 385838-387172 (Clockwise)

Preceding gene: 239616774

Following gene: 239616776

Centisome position: 16.76

GC content: 41.57

Gene sequence:

>1335_bases
ATGAAAGAGTTCAATCGAAAACTCTTAAGCATAGCACTGCCGATTACCATTCAAAACCTTATATCTATGAGCCTAAATCT
CGTTGACAATCTCATGATCGGGCAACTAGGCTCGGCTGCCATTGCTGCCGTTGGTCTCGTGAACCAGATAAATTTCGTTT
TAATACTCTTTCTTTTTGGTGCCAGCAGCGGTACTGGTGTTTTCATTTCACAGTACTGGGGAAATCGAGATCTCAAAAAC
ATAGGAAAAACTATCTCACACGTTTTGAAGATAACCTACGTGGGTGGATTCGTATTTTTCATGTTGCTTTTCTTCTTCCC
ACAGCAGATCATAAGTTTCTTCTCCAGGGATATTACCGTCGTAACAGCCGGCGTTGCATACTCAAAAATAATCTCTTTTA
CAACGTTTCTGATACCGTTCACCTTTGTGATGGCGATGGCACTTCGAACAATAGAAAAGCCAAAGATACCAATGTATATA
AGTTTCGTGGTTCTGGCTTTCAATACCGTCGGCAATTACCTTCTTATATTCGGCGTTGGCCCTTTTCCGGAAATGGGTGT
GAAGGGTGCAGCAATCGCGACTCTTTTATCAAGGATCATAGAGTTTTTTCTTTACCTGTACGTCCTGCTTAAACCGGTAA
CTGCCTTAACTATATCGAGGCATGAATTTCTGGATTTCGATACGGTTCTTTTCAGAAAACTCATGGTTGTCGCTCTGCCG
GTAATCGTGAACGAGTTACTATGGAGTGTCGGCATGACAACCTATTCTTTCATTATGGCACGTATAGGAACCGAAGCGCT
AACTGTAAAAAACATAGTTAGCACTCTGGAAAGCTTCGGCTTCATCATTTTTGGCGGGATGTCAGCAGCAACTGTAGTAA
TGGTAGGCTCAGAGCTTGGAAAGAAAAATTACGAAAAAGCTTTTAAGAATGCTATCAAGTTGTTAAATCTAATGGTGGTC
ATTGGAGTAATAACAGGAATCGGGATTATCTTGCTGTCACGCTTTTTAATAAGAATGTACAATGTCGAAGAAGTCATAAA
ATCGACCGTAGTAATGGTGATGATTATAGTGGGATTAGCACAGCCTGTAAAAATGTTCAACGGCCTCAATATAGTCGGTG
TACTGCGAAGTGGTGGAGATACAAAAACAGCAATGTTTCTTGAACTCTTCAGTCTATGGGGAATTGGAATCCCGCTGGTT
GCTCTAAGTGGTATAGTCCTCAAGTGGCCATTGCCCTTTGTGTTTTTGATGATGCTTCCGGAGGAGCTCTTTAAAGCTTC
TCTGGGTATGTTAAGAGTCCATTCGCGAAAGTGGCTAAGGAATGTGATAGATTGA

Upstream 100 bases:

>100_bases
CGCGGCTATGTTCATTTTTATGATGACAGTTACATTTTTCAGTGGTACCATGGTTTTGTTATTCAGTAGAGAAAACCCTG
AAGACTAAAGTGGGGCCAAT

Downstream 100 bases:

>100_bases
ATACTTGTTATTTTAATAAGTTTAAATCAAATTTTCAGAAGTGATATATATCGCTGTTCGAAAGAATGATAGAATATATT
GAGAATTATTCTCAATAAGC

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKEFNRKLLSIALPITIQNLISMSLNLVDNLMIGQLGSAAIAAVGLVNQINFVLILFLFGASSGTGVFISQYWGNRDLKN
IGKTISHVLKITYVGGFVFFMLLFFFPQQIISFFSRDITVVTAGVAYSKIISFTTFLIPFTFVMAMALRTIEKPKIPMYI
SFVVLAFNTVGNYLLIFGVGPFPEMGVKGAAIATLLSRIIEFFLYLYVLLKPVTALTISRHEFLDFDTVLFRKLMVVALP
VIVNELLWSVGMTTYSFIMARIGTEALTVKNIVSTLESFGFIIFGGMSAATVVMVGSELGKKNYEKAFKNAIKLLNLMVV
IGVITGIGIILLSRFLIRMYNVEEVIKSTVVMVMIIVGLAQPVKMFNGLNIVGVLRSGGDTKTAMFLELFSLWGIGIPLV
ALSGIVLKWPLPFVFLMMLPEELFKASLGMLRVHSRKWLRNVID

Sequences:

>Translated_444_residues
MKEFNRKLLSIALPITIQNLISMSLNLVDNLMIGQLGSAAIAAVGLVNQINFVLILFLFGASSGTGVFISQYWGNRDLKN
IGKTISHVLKITYVGGFVFFMLLFFFPQQIISFFSRDITVVTAGVAYSKIISFTTFLIPFTFVMAMALRTIEKPKIPMYI
SFVVLAFNTVGNYLLIFGVGPFPEMGVKGAAIATLLSRIIEFFLYLYVLLKPVTALTISRHEFLDFDTVLFRKLMVVALP
VIVNELLWSVGMTTYSFIMARIGTEALTVKNIVSTLESFGFIIFGGMSAATVVMVGSELGKKNYEKAFKNAIKLLNLMVV
IGVITGIGIILLSRFLIRMYNVEEVIKSTVVMVMIIVGLAQPVKMFNGLNIVGVLRSGGDTKTAMFLELFSLWGIGIPLV
ALSGIVLKWPLPFVFLMMLPEELFKASLGMLRVHSRKWLRNVID
>Mature_444_residues
MKEFNRKLLSIALPITIQNLISMSLNLVDNLMIGQLGSAAIAAVGLVNQINFVLILFLFGASSGTGVFISQYWGNRDLKN
IGKTISHVLKITYVGGFVFFMLLFFFPQQIISFFSRDITVVTAGVAYSKIISFTTFLIPFTFVMAMALRTIEKPKIPMYI
SFVVLAFNTVGNYLLIFGVGPFPEMGVKGAAIATLLSRIIEFFLYLYVLLKPVTALTISRHEFLDFDTVLFRKLMVVALP
VIVNELLWSVGMTTYSFIMARIGTEALTVKNIVSTLESFGFIIFGGMSAATVVMVGSELGKKNYEKAFKNAIKLLNLMVV
IGVITGIGIILLSRFLIRMYNVEEVIKSTVVMVMIIVGLAQPVKMFNGLNIVGVLRSGGDTKTAMFLELFSLWGIGIPLV
ALSGIVLKWPLPFVFLMMLPEELFKASLGMLRVHSRKWLRNVID

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=411, Percent_Identity=24.0875912408759, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI226510954, Length=446, Percent_Identity=23.542600896861, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI48994890, Length=413, Percent_Identity=22.0338983050847, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49238; Mature: 49238

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEFNRKLLSIALPITIQNLISMSLNLVDNLMIGQLGSAAIAAVGLVNQINFVLILFLFG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
ASSGTGVFISQYWGNRDLKNIGKTISHVLKITYVGGFVFFMLLFFFPQQIISFFSRDITV
CCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHE
VTAGVAYSKIISFTTFLIPFTFVMAMALRTIEKPKIPMYISFVVLAFNTVGNYLLIFGVG
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECC
PFPEMGVKGAAIATLLSRIIEFFLYLYVLLKPVTALTISRHEFLDFDTVLFRKLMVVALP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHH
VIVNELLWSVGMTTYSFIMARIGTEALTVKNIVSTLESFGFIIFGGMSAATVVMVGSELG
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCHHHC
KKNYEKAFKNAIKLLNLMVVIGVITGIGIILLSRFLIRMYNVEEVIKSTVVMVMIIVGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPVKMFNGLNIVGVLRSGGDTKTAMFLELFSLWGIGIPLVALSGIVLKWPLPFVFLMMLP
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHCHHHHHHHHHHH
EELFKASLGMLRVHSRKWLRNVID
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEFNRKLLSIALPITIQNLISMSLNLVDNLMIGQLGSAAIAAVGLVNQINFVLILFLFG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
ASSGTGVFISQYWGNRDLKNIGKTISHVLKITYVGGFVFFMLLFFFPQQIISFFSRDITV
CCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHE
VTAGVAYSKIISFTTFLIPFTFVMAMALRTIEKPKIPMYISFVVLAFNTVGNYLLIFGVG
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECC
PFPEMGVKGAAIATLLSRIIEFFLYLYVLLKPVTALTISRHEFLDFDTVLFRKLMVVALP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHH
VIVNELLWSVGMTTYSFIMARIGTEALTVKNIVSTLESFGFIIFGGMSAATVVMVGSELG
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCHHHC
KKNYEKAFKNAIKLLNLMVVIGVITGIGIILLSRFLIRMYNVEEVIKSTVVMVMIIVGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPVKMFNGLNIVGVLRSGGDTKTAMFLELFSLWGIGIPLVALSGIVLKWPLPFVFLMMLP
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHCHHHHHHHHHHH
EELFKASLGMLRVHSRKWLRNVID
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]