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The map label for this gene is thrC [H]

Identifier: 239616765

GI number: 239616765

Start: 376509

End: 377936

Strand: Direct

Name: thrC [H]

Synonym: Kole_0358

Alternate gene names: 239616765

Gene position: 376509-377936 (Clockwise)

Preceding gene: 239616764

Following gene: 239616766

Centisome position: 16.35

GC content: 44.12

Gene sequence:

>1428_bases
ATGAAAGAACTGTCATATGATGCCATAATGCAACGCAAAAACGAAATAATGAAGAAATCTGTTGGGATAGATTATGGGAA
ATACACGATTTCTGACATAGCTTTTGATTATGAAAGAATGATGAACGAAGTCGCTCTAGATATAGATACGGTACGAAAAA
TACAACTTGAGACAGGCGTAGGAAATACCAACCTCATAGAATTAAAAAATATAACCAAATTGGTGAGGTACATTTCGGAA
CCCGGGAAAGGGGCAAGGATATTTGTCAAAGACGAAGCAAGTAACCCATCTGGTAGTTTCAAAGACAGAAGAGCTTCTGT
AAGTGTGTATATGGCAAAAAAGCTTGGATATGAAGGGGTCATAGCCGCCACTAGCGGTAATTATGGTGCTTCTGTGGCGT
CACAGGCAGCCAAGCGCGGGTTGAAATGCATCATTGTTCAGGAGACATACGACAGCAACGGCATTGGACAACCTGAAATT
CTCGAGAAGGGACGTGCCTGTGAAACCTATGGTGCAGAAGTGGTCCAGCTTACCGTAGGACCTGAATTGTTCTATTATTT
TCTTGTATTACTGGAAGAAACAGGTTATTTCAATGCATCACTTTACACGCCATATGGAATCGCAGGTGTGGAAACCCTCG
GTTATGAAATAGCTTTGCAGTGCCGTGAGCAAATTGGATGTGATCCTGATTATGTGGTTGTTACCCACGCTGGTGGTGGA
AATCTGACGGGTACTGCCAGAGGGTTGCTCAAAGCAGGCGCTAAAAACACAAAAATCGTGGCTGCAAGCGTTGACTTACA
TGGCCTCCATATGGCGAGTGACAGAGACTTCAATCGAAAGTCTTTTACAACCGGCCACACAGGTTTCGGAATCCCCTTTG
CAGTGTATCCTGATAGATCTGATGTTCCCAAAAACGCCGCCAGGGCTTTGAGGTACATGGATAGATATCTACTGGTAACT
CAGGGTGAAGTTTTCTACGTTACGGAGATGCTGGCACGTCTCGAAGGAATGCAACGTGGCCCTGCTGGCAACACATCCCT
TGCCGCTGCGATTTCTCTTGCAAGAGAACTTCCCAAAGACAACATCGTAGTGGTTCAGGAAACGGAATACACGGGAGCTG
GAAAATTACCAAGTGCTCAACTAACTTTTGCTAAAAAGATGGGGGTTGAGGTCGTACGGGGAGATCCGCGAAAGCTTGAC
AAGCCAGGTAAACGGATCGTCATTCCTGAGCATCCATCACAATTGAGAGCTCTTGATGTTGATTTGCAAAAACTGAAGAA
ATCCTACATCAAAGAATTGGTTAAAAGAGGAATAAAACACCTGGAAGAGGTCGATATTGAGTTTCTGGCTGAGGATCTCA
AAACAACAAGAGAAAACGTAAAAACTCTCTTCGAGGAGGTAATCAAAGATTATGGTACAGAGAGCTGA

Upstream 100 bases:

>100_bases
CAAGATATACCCATGATTTTGGTGATTACGTTTCAGTGCTTGACGAAGCAGGAGCCGAACTTCAGGAACTGATGCGTAAA
ATAAGCGAGAGTGATGAAAG

Downstream 100 bases:

>100_bases
TGATTTTAAGGAAAGAAGTAAGCGTCTTCAGAATATGACCGATGAAGAATTGGACAGGTATTTCTGGGAACTCGCTGAAA
AAATTGTTGATCCTTTGATC

Product: Pyridoxal-5'-phosphate-dependent protein beta subunit

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKELSYDAIMQRKNEIMKKSVGIDYGKYTISDIAFDYERMMNEVALDIDTVRKIQLETGVGNTNLIELKNITKLVRYISE
PGKGARIFVKDEASNPSGSFKDRRASVSVYMAKKLGYEGVIAATSGNYGASVASQAAKRGLKCIIVQETYDSNGIGQPEI
LEKGRACETYGAEVVQLTVGPELFYYFLVLLEETGYFNASLYTPYGIAGVETLGYEIALQCREQIGCDPDYVVVTHAGGG
NLTGTARGLLKAGAKNTKIVAASVDLHGLHMASDRDFNRKSFTTGHTGFGIPFAVYPDRSDVPKNAARALRYMDRYLLVT
QGEVFYVTEMLARLEGMQRGPAGNTSLAAAISLARELPKDNIVVVQETEYTGAGKLPSAQLTFAKKMGVEVVRGDPRKLD
KPGKRIVIPEHPSQLRALDVDLQKLKKSYIKELVKRGIKHLEEVDIEFLAEDLKTTRENVKTLFEEVIKDYGTES

Sequences:

>Translated_475_residues
MKELSYDAIMQRKNEIMKKSVGIDYGKYTISDIAFDYERMMNEVALDIDTVRKIQLETGVGNTNLIELKNITKLVRYISE
PGKGARIFVKDEASNPSGSFKDRRASVSVYMAKKLGYEGVIAATSGNYGASVASQAAKRGLKCIIVQETYDSNGIGQPEI
LEKGRACETYGAEVVQLTVGPELFYYFLVLLEETGYFNASLYTPYGIAGVETLGYEIALQCREQIGCDPDYVVVTHAGGG
NLTGTARGLLKAGAKNTKIVAASVDLHGLHMASDRDFNRKSFTTGHTGFGIPFAVYPDRSDVPKNAARALRYMDRYLLVT
QGEVFYVTEMLARLEGMQRGPAGNTSLAAAISLARELPKDNIVVVQETEYTGAGKLPSAQLTFAKKMGVEVVRGDPRKLD
KPGKRIVIPEHPSQLRALDVDLQKLKKSYIKELVKRGIKHLEEVDIEFLAEDLKTTRENVKTLFEEVIKDYGTES
>Mature_475_residues
MKELSYDAIMQRKNEIMKKSVGIDYGKYTISDIAFDYERMMNEVALDIDTVRKIQLETGVGNTNLIELKNITKLVRYISE
PGKGARIFVKDEASNPSGSFKDRRASVSVYMAKKLGYEGVIAATSGNYGASVASQAAKRGLKCIIVQETYDSNGIGQPEI
LEKGRACETYGAEVVQLTVGPELFYYFLVLLEETGYFNASLYTPYGIAGVETLGYEIALQCREQIGCDPDYVVVTHAGGG
NLTGTARGLLKAGAKNTKIVAASVDLHGLHMASDRDFNRKSFTTGHTGFGIPFAVYPDRSDVPKNAARALRYMDRYLLVT
QGEVFYVTEMLARLEGMQRGPAGNTSLAAAISLARELPKDNIVVVQETEYTGAGKLPSAQLTFAKKMGVEVVRGDPRKLD
KPGKRIVIPEHPSQLRALDVDLQKLKKSYIKELVKRGIKHLEEVDIEFLAEDLKTTRENVKTLFEEVIKDYGTES

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321412, Length=322, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52425; Mature: 52425

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELSYDAIMQRKNEIMKKSVGIDYGKYTISDIAFDYERMMNEVALDIDTVRKIQLETGV
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHEEEEEECCC
GNTNLIELKNITKLVRYISEPGKGARIFVKDEASNPSGSFKDRRASVSVYMAKKLGYEGV
CCCCEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHEEEEEHHHCCCCEE
IAATSGNYGASVASQAAKRGLKCIIVQETYDSNGIGQPEILEKGRACETYGAEVVQLTVG
EEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHCCCCCCCCCCEEEEEEEC
PELFYYFLVLLEETGYFNASLYTPYGIAGVETLGYEIALQCREQIGCDPDYVVVTHAGGG
HHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
NLTGTARGLLKAGAKNTKIVAASVDLHGLHMASDRDFNRKSFTTGHTGFGIPFAVYPDRS
CCCHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCC
DVPKNAARALRYMDRYLLVTQGEVFYVTEMLARLEGMQRGPAGNTSLAAAISLARELPKD
CCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
NIVVVQETEYTGAGKLPSAQLTFAKKMGVEVVRGDPRKLDKPGKRIVIPEHPSQLRALDV
CEEEEEECCCCCCCCCCCHHHHHHHHCCCEEECCCCHHCCCCCCEEEECCCCHHHHHHHH
DLQKLKKSYIKELVKRGIKHLEEVDIEFLAEDLKTTRENVKTLFEEVIKDYGTES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKELSYDAIMQRKNEIMKKSVGIDYGKYTISDIAFDYERMMNEVALDIDTVRKIQLETGV
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHEEEEEECCC
GNTNLIELKNITKLVRYISEPGKGARIFVKDEASNPSGSFKDRRASVSVYMAKKLGYEGV
CCCCEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHEEEEEHHHCCCCEE
IAATSGNYGASVASQAAKRGLKCIIVQETYDSNGIGQPEILEKGRACETYGAEVVQLTVG
EEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHCCCCCCCCCCEEEEEEEC
PELFYYFLVLLEETGYFNASLYTPYGIAGVETLGYEIALQCREQIGCDPDYVVVTHAGGG
HHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
NLTGTARGLLKAGAKNTKIVAASVDLHGLHMASDRDFNRKSFTTGHTGFGIPFAVYPDRS
CCCHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCC
DVPKNAARALRYMDRYLLVTQGEVFYVTEMLARLEGMQRGPAGNTSLAAAISLARELPKD
CCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
NIVVVQETEYTGAGKLPSAQLTFAKKMGVEVVRGDPRKLDKPGKRIVIPEHPSQLRALDV
CEEEEEECCCCCCCCCCCHHHHHHHHCCCEEECCCCHHCCCCCCEEEECCCCHHHHHHHH
DLQKLKKSYIKELVKRGIKHLEEVDIEFLAEDLKTTRENVKTLFEEVIKDYGTES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]