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The map label for this gene is comEB [H]

Identifier: 239616728

GI number: 239616728

Start: 341966

End: 342478

Strand: Reverse

Name: comEB [H]

Synonym: Kole_0321

Alternate gene names: 239616728

Gene position: 342478-341966 (Counterclockwise)

Preceding gene: 239616729

Following gene: 239616727

Centisome position: 14.88

GC content: 39.38

Gene sequence:

>513_bases
ATGAAGAAAGATGTGATAGAAGCATTTTTAAAAAAATTTAAAGTCGAAGAAAAACCAAGAGATTCAAAGGATTGGGATTC
TTACTTCATGAGTCTTGCGCATTTGATAAAAGAACGTTCCAGCTGTTTACATAGAAAAGTTGGAGCGATCATTGTTAGAG
AAAACAGGATTCTGGCAACCGGTTATAATCAGCCCCCCTCAGGATTTCCCCACTGCAATGAAATTGAGTGTATAAGAGAT
GCGCTTTCGATACAATCCGGTGAAAATCAAGAAATCTGCTATGCTGCTCACGCTGAACAAAATGCTCTTTCTCAGGCTGC
AAAGTTTGGTATCTCTACTGATGGTGCAACCATATATGTAACTCACAAGCCTTGCTCCATTTGTGCGCGGTTAATAATCA
ATGCAGGGATAAAACGTGTTGTTTATGATGTTGATTATCCTGATCCACTGTCTGAGTTTTTGCTAGAAAAAACCGGCGTC
ATCTTAGAACATTATGAGAATGCGGGGAGGTAA

Upstream 100 bases:

>100_bases
CTGGAGATAATTACTGACAATGAGGCCAAAGAAGCAGTGAAGAAGATAATAGTGGAAGAAAAGAAACATGTGGTAACTCT
AAGGGAGTTGTTGTAAGAAT

Downstream 100 bases:

>100_bases
TCATGGCGATTACAAGATTAACCAAGTACCTGAGACAGGATAGAATGCCTCATGTATGGTGTCCGGGTTGCGGAAATGGC
GTAATAATGAAAGCATTTAT

Product: CMP/dCMP deaminase zinc-binding

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MKKDVIEAFLKKFKVEEKPRDSKDWDSYFMSLAHLIKERSSCLHRKVGAIIVRENRILATGYNQPPSGFPHCNEIECIRD
ALSIQSGENQEICYAAHAEQNALSQAAKFGISTDGATIYVTHKPCSICARLIINAGIKRVVYDVDYPDPLSEFLLEKTGV
ILEHYENAGR

Sequences:

>Translated_170_residues
MKKDVIEAFLKKFKVEEKPRDSKDWDSYFMSLAHLIKERSSCLHRKVGAIIVRENRILATGYNQPPSGFPHCNEIECIRD
ALSIQSGENQEICYAAHAEQNALSQAAKFGISTDGATIYVTHKPCSICARLIINAGIKRVVYDVDYPDPLSEFLLEKTGV
ILEHYENAGR
>Mature_170_residues
MKKDVIEAFLKKFKVEEKPRDSKDWDSYFMSLAHLIKERSSCLHRKVGAIIVRENRILATGYNQPPSGFPHCNEIECIRD
ALSIQSGENQEICYAAHAEQNALSQAAKFGISTDGATIYVTHKPCSICARLIINAGIKRVVYDVDYPDPLSEFLLEKTGV
ILEHYENAGR

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=159, Percent_Identity=35.2201257861635, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI61742821, Length=134, Percent_Identity=38.0597014925373, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321938, Length=148, Percent_Identity=37.8378378378378, Blast_Score=98, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667298, Length=151, Percent_Identity=37.0860927152318, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24667302, Length=151, Percent_Identity=37.0860927152318, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 19159; Mature: 19159

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDVIEAFLKKFKVEEKPRDSKDWDSYFMSLAHLIKERSSCLHRKVGAIIVRENRILAT
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEEE
GYNQPPSGFPHCNEIECIRDALSIQSGENQEICYAAHAEQNALSQAAKFGISTDGATIYV
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEEE
THKPCSICARLIINAGIKRVVYDVDYPDPLSEFLLEKTGVILEHYENAGR
ECCCHHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKDVIEAFLKKFKVEEKPRDSKDWDSYFMSLAHLIKERSSCLHRKVGAIIVRENRILAT
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEEE
GYNQPPSGFPHCNEIECIRDALSIQSGENQEICYAAHAEQNALSQAAKFGISTDGATIYV
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEEE
THKPCSICARLIINAGIKRVVYDVDYPDPLSEFLLEKTGVILEHYENAGR
ECCCHHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]