Click here to switch to the map view.

The map label for this gene is apt

Identifier: 239616587

GI number: 239616587

Start: 201575

End: 202087

Strand: Reverse

Name: apt

Synonym: Kole_0179

Alternate gene names: 239616587

Gene position: 202087-201575 (Counterclockwise)

Preceding gene: 239616596

Following gene: 239616586

Centisome position: 8.78

GC content: 41.91

Gene sequence:

>513_bases
GTGAATCTTAAAGACTTTATACGCGACATTCCTGATTTTCCAAAACCCGGAATTATTTTCAAAGATGTCACCCCGATGTT
AAAAGACCCCGGTGCTTTCAAAGTTTGTATTTCAAGTTTGAAAGAACTTGTAAAAGACTTTGAGTTTAATCTCATCGTTG
CTCCGGAAGCCCGTGGTTTCATTTTTGCGGCACCTCTGGCACTTGAACTTGAAAAAGGATTTGTTCCTATAAGAAAACCC
GGAAAACTCCCTTACAAAACCGTATCTGTGGAATATTCACTCGAGTATGGAACGGCGACCCTCGAGATGCATACAGATGC
AATAAAAGAAGGCGATAAGGTTTTGATCGTGGATGACGTTCTGGCAACCGGTGGAACGATGAAAGCTATAGCAGAGATGG
TAGAAAAGGTTGGGGGGACCATCAGCGGAATAGTATCTCTGGTCGAACTTTCCTTCCTTGAACCAAGAAAGAAACTTTCA
GGTTATGAAGTGAGAAGCATCATAACCTATTGA

Upstream 100 bases:

>100_bases
TATTTATTTCACTTGGATTATAACATGCAACTATAAAAAATGGATTTTGCCTTGTGTTAAAATAAGCTTTGTTGGTAGAG
AATTAAGGGGAGGAGATAGT

Downstream 100 bases:

>100_bases
GGTGAGGTTCTATATGCTAAAGTTTGATTTTTCCTTCGCCTTTAAAGAGAATCTAGGAACAGGTCTTTCAAAGGATGAGG
TTTTTAATAACAGGGAATTC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNLKDFIRDIPDFPKPGIIFKDVTPMLKDPGAFKVCISSLKELVKDFEFNLIVAPEARGFIFAAPLALELEKGFVPIRKP
GKLPYKTVSVEYSLEYGTATLEMHTDAIKEGDKVLIVDDVLATGGTMKAIAEMVEKVGGTISGIVSLVELSFLEPRKKLS
GYEVRSIITY

Sequences:

>Translated_170_residues
MNLKDFIRDIPDFPKPGIIFKDVTPMLKDPGAFKVCISSLKELVKDFEFNLIVAPEARGFIFAAPLALELEKGFVPIRKP
GKLPYKTVSVEYSLEYGTATLEMHTDAIKEGDKVLIVDDVLATGGTMKAIAEMVEKVGGTISGIVSLVELSFLEPRKKLS
GYEVRSIITY
>Mature_170_residues
MNLKDFIRDIPDFPKPGIIFKDVTPMLKDPGAFKVCISSLKELVKDFEFNLIVAPEARGFIFAAPLALELEKGFVPIRKP
GKLPYKTVSVEYSLEYGTATLEMHTDAIKEGDKVLIVDDVLATGGTMKAIAEMVEKVGGTISGIVSLVELSFLEPRKKLS
GYEVRSIITY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=44.9101796407186, Blast_Score=143, Evalue=7e-35,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.9338842975207, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1786675, Length=168, Percent_Identity=49.4047619047619, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=38.2352941176471, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=39.8773006134969, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=163, Percent_Identity=36.1963190184049, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=45.4022988505747, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_KOSOT (C5CIH1)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002939909.1
- ProteinModelPortal:   C5CIH1
- GeneID:   7968331
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_0179
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18742; Mature: 18742

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKDFIRDIPDFPKPGIIFKDVTPMLKDPGAFKVCISSLKELVKDFEFNLIVAPEARGF
CCHHHHHHHCCCCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCE
IFAAPLALELEKGFVPIRKPGKLPYKTVSVEYSLEYGTATLEMHTDAIKEGDKVLIVDDV
EEECCEEEECCCCEECCCCCCCCCEEEEEEEEEEECCEEEEEECHHHHHCCCEEEEEECH
LATGGTMKAIAEMVEKVGGTISGIVSLVELSFLEPRKKLSGYEVRSIITY
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCEEEECC
>Mature Secondary Structure
MNLKDFIRDIPDFPKPGIIFKDVTPMLKDPGAFKVCISSLKELVKDFEFNLIVAPEARGF
CCHHHHHHHCCCCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCE
IFAAPLALELEKGFVPIRKPGKLPYKTVSVEYSLEYGTATLEMHTDAIKEGDKVLIVDDV
EEECCEEEECCCCEECCCCCCCCCEEEEEEEEEEECCEEEEEECHHHHHCCCEEEEEECH
LATGGTMKAIAEMVEKVGGTISGIVSLVELSFLEPRKKLSGYEVRSIITY
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA