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The map label for this gene is thyX

Identifier: 239616439

GI number: 239616439

Start: 36081

End: 36773

Strand: Reverse

Name: thyX

Synonym: Kole_0028

Alternate gene names: 239616439

Gene position: 36773-36081 (Counterclockwise)

Preceding gene: 239616440

Following gene: 239616438

Centisome position: 1.6

GC content: 43.15

Gene sequence:

>693_bases
ATGGAGATAAAGGTACTTGAAAAGGGTTTTATCAGACTTGTAGAGGTAATGGGGGATGACTTTTCTGCTGTTCAGGCTGC
GAGAGTCAGTTATGGGAAAGGATTAACAACCCCCGAACGTGATAAAAAACTGATTTTTTATCTCATGGAGCACGGACACC
ACTCTCCTTTTGAACATATCATCTTTAAGTTTCACATAAAACTGCCCATCTTTGTGATGCGCCAGCTGGTGAGGCATCGA
ATTGCTTCGATAAATGAGCGTAGCGGAAGATATACTGAATTCAGCGATGAGTGGTACATCCCCGAAAGGATCAGAACACC
CGATAAAGTCAATCGGCAGGGGTCAGTGTTTGTCGATGATGACGATCTGAATTCAGAGGGGATAAGACTTATTGAAGAAA
CCATCGAAAAAACTTATCAGGCTTACAAAAGGCTTTTGGAAATGGGTGTGGCACGGGAACTCGCCAGAATCGTGTTGCCA
ACATCGATGTACACCGAGTGTTACTGGACAATAAACGCGAGGAGCATGATGAATTTTTTGAATCTGAGAGCGGATTCCCA
TGCTCAGTATGAAATGCAGCAATATGCTCTCGCAGTTGCAAAGATATTCAAAAGTAAATGTCCGGTTACCTATGAAGCCT
TCCTTAATTTTGCGTATACCGGCGATCTTTTGAAAACGGAGGGATGCTTATGA

Upstream 100 bases:

>100_bases
TTGCTGCGGTTGTACTTGGGTTAATTTTGGTAGAATATATATATATAAAGAGAAGAAAAAAACAGGAAGAAGAAGCCTTA
CGGAAGTAGAGGAGGATTCC

Downstream 100 bases:

>100_bases
CTCTTGAGGAAATTTGCAAGTTTTTGGGCTGCGAAATTCTGAATGATACCGGGGATTTAGATAAACGGCAGATCGAATAC
ATAGGAGCTGCTGATCTAAT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MEIKVLEKGFIRLVEVMGDDFSAVQAARVSYGKGLTTPERDKKLIFYLMEHGHHSPFEHIIFKFHIKLPIFVMRQLVRHR
IASINERSGRYTEFSDEWYIPERIRTPDKVNRQGSVFVDDDDLNSEGIRLIEETIEKTYQAYKRLLEMGVARELARIVLP
TSMYTECYWTINARSMMNFLNLRADSHAQYEMQQYALAVAKIFKSKCPVTYEAFLNFAYTGDLLKTEGCL

Sequences:

>Translated_230_residues
MEIKVLEKGFIRLVEVMGDDFSAVQAARVSYGKGLTTPERDKKLIFYLMEHGHHSPFEHIIFKFHIKLPIFVMRQLVRHR
IASINERSGRYTEFSDEWYIPERIRTPDKVNRQGSVFVDDDDLNSEGIRLIEETIEKTYQAYKRLLEMGVARELARIVLP
TSMYTECYWTINARSMMNFLNLRADSHAQYEMQQYALAVAKIFKSKCPVTYEAFLNFAYTGDLLKTEGCL
>Mature_230_residues
MEIKVLEKGFIRLVEVMGDDFSAVQAARVSYGKGLTTPERDKKLIFYLMEHGHHSPFEHIIFKFHIKLPIFVMRQLVRHR
IASINERSGRYTEFSDEWYIPERIRTPDKVNRQGSVFVDDDDLNSEGIRLIEETIEKTYQAYKRLLEMGVARELARIVLP
TSMYTECYWTINARSMMNFLNLRADSHAQYEMQQYALAVAKIFKSKCPVTYEAFLNFAYTGDLLKTEGCL

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_KOSOT (C5CHB8)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002939761.1
- GeneID:   7968853
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_0028
- ProtClustDB:   PRK00847
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 26912; Mature: 26912

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKVLEKGFIRLVEVMGDDFSAVQAARVSYGKGLTTPERDKKLIFYLMEHGHHSPFEHI
CCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHH
IFKFHIKLPIFVMRQLVRHRIASINERSGRYTEFSDEWYIPERIRTPDKVNRQGSVFVDD
HHHHEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCCCEEECC
DDLNSEGIRLIEETIEKTYQAYKRLLEMGVARELARIVLPTSMYTECYWTINARSMMNFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEEECHHHHHHHH
NLRADSHAQYEMQQYALAVAKIFKSKCPVTYEAFLNFAYTGDLLKTEGCL
HHCCCCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MEIKVLEKGFIRLVEVMGDDFSAVQAARVSYGKGLTTPERDKKLIFYLMEHGHHSPFEHI
CCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHH
IFKFHIKLPIFVMRQLVRHRIASINERSGRYTEFSDEWYIPERIRTPDKVNRQGSVFVDD
HHHHEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCCCEEECC
DDLNSEGIRLIEETIEKTYQAYKRLLEMGVARELARIVLPTSMYTECYWTINARSMMNFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEEECHHHHHHHH
NLRADSHAQYEMQQYALAVAKIFKSKCPVTYEAFLNFAYTGDLLKTEGCL
HHCCCCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA