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The map label for this gene is panB [H]

Identifier: 238924850

GI number: 238924850

Start: 2365622

End: 2366506

Strand: Reverse

Name: panB [H]

Synonym: EUBREC_2501

Alternate gene names: 238924850

Gene position: 2366506-2365622 (Counterclockwise)

Preceding gene: 238924851

Following gene: 238924849

Centisome position: 68.6

GC content: 46.89

Gene sequence:

>885_bases
ATGGTTCCAAGTAGTTACAAGAAACGGATTGTTGCAGAAAGACAGAGGGATTGGACAATGAAAAATACAGTAGTAACTTT
TAAACAGGCAAAGGAAAAGGGCGAGAAGCTCACGATGCTCACAGCATATGATTATTCGACAGCAAAGCTCATAGATGAGG
CCGGAATCAATGCAATTTTAGTAGGAGATTCTCTCGGCATGGTGGTGCTTGGCTATGAGGATACACTTTCAGTGACTATG
GAGGATATGATTCATCACAGCGCAGCTGTTTCAAGAGGCATAAAGGATACGCTGCTCATCACAGATATGCCTTTTATGTC
ATATCAGACATCGGTTTATGATGCTGTGGTCAATGCAGGACGACTCGTGAAGGAAGGCCATGCGCAGGCAGTCAAGCTCG
AGGGTGGCAAGGAGGTATGTCCACAGATAAAGGCTATCGTGGATGCATCAATTCCGGTATGTGCACATTTAGGGCTTACA
CCACAGTCAGTAAATGCATTTGGCGGCTTCAAGGTGCAGGGAAAGGGTGAAGAGGCAGCACAGAAGCTTCTTGACGATGC
CCGTGCAGTTGAGGCGGCAGGAGCATTTGCAGTAGTGCTCGAGTGCGTGCCAAAGGCACTTGCCAAAAAAATCACAGAGA
GCATAAGCATACCTACAATCGGTATCGGAGCGGGAGCAGACTGCGACGGCCAGGTGCTCGTATATCAGGATATGCTTGCC
ATGTATGCAAACATGAAGCCGAAATTTGTAAAGCAGTTTGCACAGGTCGGAAAAGAAATGAATGAGGCGTTCACAGCCTA
CAAAAAGGCTGTTGAGGAGGGAAGCTTCCCTGGTGAGGAGCATACCTTTAAGATGGATGAGACAATAATTGACAAGCTGT
ATTAG

Upstream 100 bases:

>100_bases
AAATGCTTGGTACAAAACTAGTAAATATTGCTGAAAAAAAGAATCCTGATAAGGATTACACTCAGATGATGGAATTGCTA
AGAGGCTGACAATACCGTGA

Downstream 100 bases:

>100_bases
TATCGAAAATAGTATTGAAGAATATTTACAAAAAATAGCTACGAAAAATAAAAGAATAAGGAGACATAAAATGTTAATAT
ACGGACAAATCGAACAGGTA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MVPSSYKKRIVAERQRDWTMKNTVVTFKQAKEKGEKLTMLTAYDYSTAKLIDEAGINAILVGDSLGMVVLGYEDTLSVTM
EDMIHHSAAVSRGIKDTLLITDMPFMSYQTSVYDAVVNAGRLVKEGHAQAVKLEGGKEVCPQIKAIVDASIPVCAHLGLT
PQSVNAFGGFKVQGKGEEAAQKLLDDARAVEAAGAFAVVLECVPKALAKKITESISIPTIGIGAGADCDGQVLVYQDMLA
MYANMKPKFVKQFAQVGKEMNEAFTAYKKAVEEGSFPGEEHTFKMDETIIDKLY

Sequences:

>Translated_294_residues
MVPSSYKKRIVAERQRDWTMKNTVVTFKQAKEKGEKLTMLTAYDYSTAKLIDEAGINAILVGDSLGMVVLGYEDTLSVTM
EDMIHHSAAVSRGIKDTLLITDMPFMSYQTSVYDAVVNAGRLVKEGHAQAVKLEGGKEVCPQIKAIVDASIPVCAHLGLT
PQSVNAFGGFKVQGKGEEAAQKLLDDARAVEAAGAFAVVLECVPKALAKKITESISIPTIGIGAGADCDGQVLVYQDMLA
MYANMKPKFVKQFAQVGKEMNEAFTAYKKAVEEGSFPGEEHTFKMDETIIDKLY
>Mature_294_residues
MVPSSYKKRIVAERQRDWTMKNTVVTFKQAKEKGEKLTMLTAYDYSTAKLIDEAGINAILVGDSLGMVVLGYEDTLSVTM
EDMIHHSAAVSRGIKDTLLITDMPFMSYQTSVYDAVVNAGRLVKEGHAQAVKLEGGKEVCPQIKAIVDASIPVCAHLGLT
PQSVNAFGGFKVQGKGEEAAQKLLDDARAVEAAGAFAVVLECVPKALAKKITESISIPTIGIGAGADCDGQVLVYQDMLA
MYANMKPKFVKQFAQVGKEMNEAFTAYKKAVEEGSFPGEEHTFKMDETIIDKLY

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=265, Percent_Identity=49.0566037735849, Blast_Score=256, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319653, Length=301, Percent_Identity=34.8837209302326, Blast_Score=193, Evalue=3e-50,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 31903; Mature: 31903

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPSSYKKRIVAERQRDWTMKNTVVTFKQAKEKGEKLTMLTAYDYSTAKLIDEAGINAIL
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHCCCCEEE
VGDSLGMVVLGYEDTLSVTMEDMIHHSAAVSRGIKDTLLITDMPFMSYQTSVYDAVVNAG
EECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHH
RLVKEGHAQAVKLEGGKEVCPQIKAIVDASIPVCAHLGLTPQSVNAFGGFKVQGKGEEAA
HHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHCCCCEEEECCCHHHH
QKLLDDARAVEAAGAFAVVLECVPKALAKKITESISIPTIGIGAGADCDGQVLVYQDMLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEHHHHHHH
MYANMKPKFVKQFAQVGKEMNEAFTAYKKAVEEGSFPGEEHTFKMDETIIDKLY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCC
>Mature Secondary Structure
MVPSSYKKRIVAERQRDWTMKNTVVTFKQAKEKGEKLTMLTAYDYSTAKLIDEAGINAIL
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHCCCCEEE
VGDSLGMVVLGYEDTLSVTMEDMIHHSAAVSRGIKDTLLITDMPFMSYQTSVYDAVVNAG
EECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHH
RLVKEGHAQAVKLEGGKEVCPQIKAIVDASIPVCAHLGLTPQSVNAFGGFKVQGKGEEAA
HHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHCCCCEEEECCCHHHH
QKLLDDARAVEAAGAFAVVLECVPKALAKKITESISIPTIGIGAGADCDGQVLVYQDMLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEHHHHHHH
MYANMKPKFVKQFAQVGKEMNEAFTAYKKAVEEGSFPGEEHTFKMDETIIDKLY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA