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The map label for this gene is cysK [H]

Identifier: 238924826

GI number: 238924826

Start: 2345364

End: 2346299

Strand: Reverse

Name: cysK [H]

Synonym: EUBREC_2477

Alternate gene names: 238924826

Gene position: 2346299-2345364 (Counterclockwise)

Preceding gene: 238924827

Following gene: 238924825

Centisome position: 68.01

GC content: 48.18

Gene sequence:

>936_bases
ATGGCAAAAATTGCAAAGCAGCTCACAGAGCTGATAGGTCACACTCCGCTTCTGGAGCTGACCAACTATGAAAAAGCCCT
TGGGCTTGAAGCAAAAATCATAGCAAAGCTGGAGTATTTCAATCCACTTGGAAGTGTAAAGGACAGGGTGGCGGCAGCTA
TGATAGAACAGGGCATAAAGGATGGAAAGATAAATCAGGACACAATAATCATAGAGCCGACAAGTGGCAATACCGGAATC
GGACTTGCATTTGTGGCAGCCTCAAAGGGGCTTCACCTGATACTTATCATGCCTGATACCATGAGCGTTGAGAGAAGAAA
AATCGTCACAGCGCTTGGCGCAGAGATAAAGCTCACACCGGGGCGTGAGGGCATGAAGGGTGCAATCGATGAGGCGCAGA
GACTTAAAGAGCATTATGGCAATGCCTTTATTCCACAGCAGTTTGAGAATCAGGCCAATCCGGATATCCACAGAGCTACA
ACCGCTCAGGAAATCTGGGAGGATACAGATGGAAAGGTAGATATCTTTGTATCATCTGTCGGAACAGGCGGCACATGTAC
AGGCACCGGGCTTGGATTAAGAGACCATAATCCTGATGTAAGGATAGTAGCTGTTGAACCAAAGAGCTCACCGGTACTCT
CAGGTGGAAGACCGGGGCCTCACAAGATACAGGGAATCGGTGCAGGCTTTATTCCAAAGGTCATGCGCATGGATATAGTG
GATGAGGTGATTCCGGTTGAGAATGAGGCAGCCTTTGACAAGGCAAGAGAGGTTGCAAAGAGCGACGGACTTCTCGTCGG
CATATCCTCAGGAGCAGCAATATATGCGGCAACAGAGCTTGCAAAGAGGACTGAGAACAAAGGAAAGAATATCGTGGTGC
TGCTTCCGGATACAGGCGAGAGATACCTGTCCACACAGCTTTTTACAGTAAACTAA

Upstream 100 bases:

>100_bases
TAGAAATCATATTTGAATGGTAGGAAATCCAGGCCATACAAACTAAGCACAAACTCATAACAAACTCAAAACAAACATTA
ACAAAAAAGAGGTAATATCA

Downstream 100 bases:

>100_bases
TGGTATATAGGACAACCGACGGCATAAGCTACAGTGTCTGAATCTGTAATATGAAAAATGAGAAATATACATGAGAAATA
TACATAAATACACGGCAGCC

Product: hypothetical protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAKIAKQLTELIGHTPLLELTNYEKALGLEAKIIAKLEYFNPLGSVKDRVAAAMIEQGIKDGKINQDTIIIEPTSGNTGI
GLAFVAASKGLHLILIMPDTMSVERRKIVTALGAEIKLTPGREGMKGAIDEAQRLKEHYGNAFIPQQFENQANPDIHRAT
TAQEIWEDTDGKVDIFVSSVGTGGTCTGTGLGLRDHNPDVRIVAVEPKSSPVLSGGRPGPHKIQGIGAGFIPKVMRMDIV
DEVIPVENEAAFDKAREVAKSDGLLVGISSGAAIYAATELAKRTENKGKNIVVLLPDTGERYLSTQLFTVN

Sequences:

>Translated_311_residues
MAKIAKQLTELIGHTPLLELTNYEKALGLEAKIIAKLEYFNPLGSVKDRVAAAMIEQGIKDGKINQDTIIIEPTSGNTGI
GLAFVAASKGLHLILIMPDTMSVERRKIVTALGAEIKLTPGREGMKGAIDEAQRLKEHYGNAFIPQQFENQANPDIHRAT
TAQEIWEDTDGKVDIFVSSVGTGGTCTGTGLGLRDHNPDVRIVAVEPKSSPVLSGGRPGPHKIQGIGAGFIPKVMRMDIV
DEVIPVENEAAFDKAREVAKSDGLLVGISSGAAIYAATELAKRTENKGKNIVVLLPDTGERYLSTQLFTVN
>Mature_310_residues
AKIAKQLTELIGHTPLLELTNYEKALGLEAKIIAKLEYFNPLGSVKDRVAAAMIEQGIKDGKINQDTIIIEPTSGNTGIG
LAFVAASKGLHLILIMPDTMSVERRKIVTALGAEIKLTPGREGMKGAIDEAQRLKEHYGNAFIPQQFENQANPDIHRATT
AQEIWEDTDGKVDIFVSSVGTGGTCTGTGLGLRDHNPDVRIVAVEPKSSPVLSGGRPGPHKIQGIGAGFIPKVMRMDIVD
EVIPVENEAAFDKAREVAKSDGLLVGISSGAAIYAATELAKRTENKGKNIVVLLPDTGERYLSTQLFTVN

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=39.6166134185303, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=39.6166134185303, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=39.6166134185303, Blast_Score=218, Evalue=4e-57,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=49.375, Blast_Score=263, Evalue=9e-72,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=40.1993355481728, Blast_Score=200, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=48.6666666666667, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=50.4885993485342, Blast_Score=264, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=46.843853820598, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=47.4576271186441, Blast_Score=253, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=45.1505016722408, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=47.4178403755869, Blast_Score=190, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=309, Percent_Identity=38.1877022653722, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI25147552, Length=309, Percent_Identity=36.8932038834951, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17561716, Length=117, Percent_Identity=46.1538461538462, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=309, Percent_Identity=25.5663430420712, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=34.9206349206349, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=34.0490797546012, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24643623, Length=313, Percent_Identity=38.0191693290735, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI20129101, Length=313, Percent_Identity=38.0191693290735, Blast_Score=181, Evalue=7e-46,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33330; Mature: 33199

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIAKQLTELIGHTPLLELTNYEKALGLEAKIIAKLEYFNPLGSVKDRVAAAMIEQGIK
CCHHHHHHHHHHCCCCEEEECCCHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHHHHCCCC
DGKINQDTIIIEPTSGNTGIGLAFVAASKGLHLILIMPDTMSVERRKIVTALGAEIKLTP
CCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCEEEECC
GREGMKGAIDEAQRLKEHYGNAFIPQQFENQANPDIHRATTAQEIWEDTDGKVDIFVSSV
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEC
GTGGTCTGTGLGLRDHNPDVRIVAVEPKSSPVLSGGRPGPHKIQGIGAGFIPKVMRMDIV
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
DEVIPVENEAAFDKAREVAKSDGLLVGISSGAAIYAATELAKRTENKGKNIVVLLPDTGE
HHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHCCCCEEEEEECCCCC
RYLSTQLFTVN
HHHEEEEEEEC
>Mature Secondary Structure 
AKIAKQLTELIGHTPLLELTNYEKALGLEAKIIAKLEYFNPLGSVKDRVAAAMIEQGIK
CHHHHHHHHHHCCCCEEEECCCHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHHHHCCCC
DGKINQDTIIIEPTSGNTGIGLAFVAASKGLHLILIMPDTMSVERRKIVTALGAEIKLTP
CCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCEEEECC
GREGMKGAIDEAQRLKEHYGNAFIPQQFENQANPDIHRATTAQEIWEDTDGKVDIFVSSV
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEC
GTGGTCTGTGLGLRDHNPDVRIVAVEPKSSPVLSGGRPGPHKIQGIGAGFIPKVMRMDIV
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
DEVIPVENEAAFDKAREVAKSDGLLVGISSGAAIYAATELAKRTENKGKNIVVLLPDTGE
HHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHCCCCEEEEEECCCCC
RYLSTQLFTVN
HHHEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]