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The map label for this gene is cobD [H]

Identifier: 238924189

GI number: 238924189

Start: 1707958

End: 1709073

Strand: Direct

Name: cobD [H]

Synonym: EUBREC_1827

Alternate gene names: 238924189

Gene position: 1707958-1709073 (Clockwise)

Preceding gene: 238924182

Following gene: 238924203

Centisome position: 49.51

GC content: 40.23

Gene sequence:

>1116_bases
ATGCAAATAGAAAGGAAATTACAGCTAATGATAGAACAAAAGGAGCATTTTCACGGCAGTGACCTTGAAAAAATAGAAAA
AATATACGGTATAAAGAAAGAAAATATTATGAGCTTTGCAGCAAATGTCAACCCACTCGGTGAATCCGGTAAACTAAAAA
CTGCACTGTCTGAGCGCATTGATGCAATCACAAAATACCCTGACAGGGAGTATACTTCTCTCAGAAAGGCTATCGGCAGC
TACTGCAAGTGCGATTACAATCACATAACAGTCGGAAACGGATGCACGGAGCTCATCTCTCTTTTCATTCAGATTACAGC
TCCTAAAAAGACACTTCTGCTTGGTCCGACTTACTCTGAGTACGAGCGCGACTTAAGGATAAACGGCAGTGATATCTCAT
ACTATTTTCTTAAGGAAAAGGATGATTTTAAGATTAATTCGGATGAATTCATCTCTGCAATCACAGCTGATACCGACCTT
GTCATCATCTGTAACCCCAACAATCCGACTGGCAGTCTTATCACACAGGATAAGCTCAAAACAATTTTAACCCACTGTAA
AGAGACAAATACTTATGTGATGATAGACGAGACATATATAGAGTTTGTGCCGGATGTTGATGAGCTTTCAGCAATACCTC
TGACTGAATTGTTTGACAATGTGATTATTTTACGCGGCACATCCAAGTTTTTTGCCACTCCGGGACTTCGCCTGGGCTAT
GCCATCACATCAAATTCACAAATTCTTACAGACATAAACACAAACAAAAATCCGTGGATGATTAACTCTCTCGCCGTTGT
TGCAGGCGAAACCATGTTTTTGGATGAAGAATATATAGATAAAACAAGAAGCTTGATACTTTCGGAGAAAACCAGATGCA
GGCAATTGATTGAAAAATCACACAAATTCAAGCTTTATCCATCCTACAGCAACTTCTATCTGCTTAAGATACTTGATGAA
GGCGTGGATGCACATATGCTATTTGAGCGCGCCATAAGGCAGGGCATGATGATAAGGGATTGCTCTACCTTCCCCGGACT
CAAGGAGCGGTTCATACGATTTTGTATAATGAAGCCAGAGGACAACACAAGGCTTATTAATTGCCTTACACAATGA

Upstream 100 bases:

>100_bases
ATACGTGCTCGCACAATTGTTACCCCGTTTACGTTAAATGTTGATTTTTTATATACATATTATATAATGTAAATTATATA
CGATTTGCAATGCTGTTGCA

Downstream 100 bases:

>100_bases
TGCTAAATGCCTTTATATAAACATAACATATAACCAAAAAGCCTCCGGAAGGATTTAATCCAGCCGGAGGCTTTTTTATA
AAGTGAAACATAGAATATGC

Product: putative histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MQIERKLQLMIEQKEHFHGSDLEKIEKIYGIKKENIMSFAANVNPLGESGKLKTALSERIDAITKYPDREYTSLRKAIGS
YCKCDYNHITVGNGCTELISLFIQITAPKKTLLLGPTYSEYERDLRINGSDISYYFLKEKDDFKINSDEFISAITADTDL
VIICNPNNPTGSLITQDKLKTILTHCKETNTYVMIDETYIEFVPDVDELSAIPLTELFDNVIILRGTSKFFATPGLRLGY
AITSNSQILTDINTNKNPWMINSLAVVAGETMFLDEEYIDKTRSLILSEKTRCRQLIEKSHKFKLYPSYSNFYLLKILDE
GVDAHMLFERAIRQGMMIRDCSTFPGLKERFIRFCIMKPEDNTRLINCLTQ

Sequences:

>Translated_371_residues
MQIERKLQLMIEQKEHFHGSDLEKIEKIYGIKKENIMSFAANVNPLGESGKLKTALSERIDAITKYPDREYTSLRKAIGS
YCKCDYNHITVGNGCTELISLFIQITAPKKTLLLGPTYSEYERDLRINGSDISYYFLKEKDDFKINSDEFISAITADTDL
VIICNPNNPTGSLITQDKLKTILTHCKETNTYVMIDETYIEFVPDVDELSAIPLTELFDNVIILRGTSKFFATPGLRLGY
AITSNSQILTDINTNKNPWMINSLAVVAGETMFLDEEYIDKTRSLILSEKTRCRQLIEKSHKFKLYPSYSNFYLLKILDE
GVDAHMLFERAIRQGMMIRDCSTFPGLKERFIRFCIMKPEDNTRLINCLTQ
>Mature_371_residues
MQIERKLQLMIEQKEHFHGSDLEKIEKIYGIKKENIMSFAANVNPLGESGKLKTALSERIDAITKYPDREYTSLRKAIGS
YCKCDYNHITVGNGCTELISLFIQITAPKKTLLLGPTYSEYERDLRINGSDISYYFLKEKDDFKINSDEFISAITADTDL
VIICNPNNPTGSLITQDKLKTILTHCKETNTYVMIDETYIEFVPDVDELSAIPLTELFDNVIILRGTSKFFATPGLRLGY
AITSNSQILTDINTNKNPWMINSLAVVAGETMFLDEEYIDKTRSLILSEKTRCRQLIEKSHKFKLYPSYSNFYLLKILDE
GVDAHMLFERAIRQGMMIRDCSTFPGLKERFIRFCIMKPEDNTRLINCLTQ

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=322, Percent_Identity=23.2919254658385, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788627, Length=163, Percent_Identity=26.9938650306748, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=295, Percent_Identity=26.7796610169492, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42589; Mature: 42589

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIERKLQLMIEQKEHFHGSDLEKIEKIYGIKKENIMSFAANVNPLGESGKLKTALSERI
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHH
DAITKYPDREYTSLRKAIGSYCKCDYNHITVGNGCTELISLFIQITAPKKTLLLGPTYSE
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHEEEECCCEEEEECCCHHH
YERDLRINGSDISYYFLKEKDDFKINSDEFISAITADTDLVIICNPNNPTGSLITQDKLK
HCCCEEECCCCEEEEEEECCCCCEECHHHHHHHEECCCCEEEEECCCCCCCCCEEHHHHH
TILTHCKETNTYVMIDETYIEFVPDVDELSAIPLTELFDNVIILRGTSKFFATPGLRLGY
HHHHHHCCCCCEEEEECHHHHHCCCHHHHCCCCHHHHHCCEEEEEECCHHHCCCCCEEEE
AITSNSQILTDINTNKNPWMINSLAVVAGETMFLDEEYIDKTRSLILSEKTRCRQLIEKS
EEECCCEEEEECCCCCCCEEEEEEHHHCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHCC
HKFKLYPSYSNFYLLKILDEGVDAHMLFERAIRQGMMIRDCSTFPGLKERFIRFCIMKPE
CCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHEEECCC
DNTRLINCLTQ
CCCCHHHEECC
>Mature Secondary Structure
MQIERKLQLMIEQKEHFHGSDLEKIEKIYGIKKENIMSFAANVNPLGESGKLKTALSERI
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHH
DAITKYPDREYTSLRKAIGSYCKCDYNHITVGNGCTELISLFIQITAPKKTLLLGPTYSE
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHEEEECCCEEEEECCCHHH
YERDLRINGSDISYYFLKEKDDFKINSDEFISAITADTDLVIICNPNNPTGSLITQDKLK
HCCCEEECCCCEEEEEEECCCCCEECHHHHHHHEECCCCEEEEECCCCCCCCCEEHHHHH
TILTHCKETNTYVMIDETYIEFVPDVDELSAIPLTELFDNVIILRGTSKFFATPGLRLGY
HHHHHHCCCCCEEEEECHHHHHCCCHHHHCCCCHHHHHCCEEEEEECCHHHCCCCCEEEE
AITSNSQILTDINTNKNPWMINSLAVVAGETMFLDEEYIDKTRSLILSEKTRCRQLIEKS
EEECCCEEEEECCCCCCCEEEEEEHHHCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHCC
HKFKLYPSYSNFYLLKILDEGVDAHMLFERAIRQGMMIRDCSTFPGLKERFIRFCIMKPE
CCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHEEECCC
DNTRLINCLTQ
CCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]