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The map label for this gene is dxs [H]

Identifier: 238924088

GI number: 238924088

Start: 1605930

End: 1607684

Strand: Direct

Name: dxs [H]

Synonym: EUBREC_1726

Alternate gene names: 238924088

Gene position: 1605930-1607684 (Clockwise)

Preceding gene: 238924087

Following gene: 238924089

Centisome position: 46.55

GC content: 42.39

Gene sequence:

>1755_bases
ATGTATCTTGAGAAAATTAACGGACCAGAAGATGTAAAGAAAATTAAGATAGATGAACTGCCGGTGCTGGCGCAGGAGAT
AAGAGATGCCCTTTTGGTAAGAGCAAGTAAGCATGGCGGACATTTTGGACCGAATTTTGGAATGGTAGAGGCGACAATCG
CTTTACATTATGTATTTGAATCACCTAAGGATAAAATTGTTTATGATGTATCGCACCAGAGTTATCCTCATAAGATGCTT
ACGGGGCGTAAGGAAGCGTATTTGTCTGAACAGCACTATGATGATGTGTCAGGCTATACAAATCCAAACGAGAGCGAGCA
TGATTTTTTTACAGTCGGACATACATCAACATCGGTCAGTCTGGCTGCAGGTCTTGCAAAGGCAAGGAACTTAAAGGGTG
AAAACGGCAATGTGATTGCTGTCATCGGAGACGGCTCATTAAGCGGAGGAGAAGCACTTGAGGGACTTGATTTTGCTGCT
GAGCTTCAAAGCAATTTTATTATTATAGTAAATGACAACGATATGTCGATTGCTGAAAATCATGGAGGTCTCTATCAGAA
TCTTGCTCTGCTTCGAAAGACTGACGGTCAGACAGAATGCAATCTGTTTAAGGCTATGGGACTTGACTATGTGTATGTGG
ACAGGGGCAACGATGTTGCAGCTCTTATTAAGGCATTTAAAGAGGTCAAGGACAGCACTAAACCGGTTGTAGTGCATATA
AACACACTTAAGGGCAAGGGTTATGCCCCTGCAGAAAAATGCAAGGAGCAGTGGCATTACAGCGGTCCATTCGATATAGA
AACAGGAAAGCCGCTATTTGACAATGTGGAAGAGGATTATTCTTCTGTGACCTGTGAATATCTGCTTGAAAAGATGAAAA
ATGATTCTTCTGTTGTTGCAATTACTTCCGGTACGCCGACTGTTATGGGATTTACAGAAGATAAGAGAAAAGAGGCTGGC
AGTCAGTTTGTCGATGTAGGTATTGCAGAGGAGACTGCAGTGGCACTGGCATCAGGTATCGCAGTAAATGGTGGTAAACC
ATTTTATGGTGTATACAGTTCGTTTGTACAGAGAACCTTTGACCAGGTATCACAGGATGTCTGCATCAATAACAGTCCGA
TTACAATGGTAATATATCAGGGTTCCGTATATGGAATGAATGACGTTACACACTTAGGCTTTCAGGATATTCCGATGCTT
TCAAATATTCCAAATCTGGTATATCTGGCACCGGCAACAAAGGAAGAGTATCTGGCCATGCTCGACTGGAGTATGGAGCA
GACATCTTATCCGGTTGCAATAAAGCTGCCGGGCGGACCGATGATTTCAGATGGTTCAAGGGTGACAAAGGATTTTGGCA
GACTCAACAGATATGAGGTGGTTCAGACAGGAGAAAAGATTGCGATTATCGGTCTGGGAACCTTCTTTGAACTGGCAAAG
GAGGCTGCGAAGCTTCTTAAAGAAGAAGCCGGAATCAACGCAACTGTAATCAATCCGTATTACATCACCGGATTGGATGA
GGCGCTTTTGACTAAGCTTAAGCAAAATCATGATACTGTTATTACTTTAGAGGATGGTATTTTAGATGGCGGCTTTGGTG
AAAAAATCGCACGATTCTATGGTGCAAGCAATATGAAAGTGATGAATTATGGATTGAAGAAGGAATTTCTTGACAGGTAT
GACGTGGATGCTGTACTGAAGGAGAATCATCTGACTGCAGAGCAGATTGTGGAGGATGTGTTATCTATTTTATAA

Upstream 100 bases:

>100_bases
GAAAACACGATGGAACGCTTACAGTATAAAATTTCTAAATACGAGAATGCGATAAAGACAGGTGAATTGACCTGGGACAA
ATAGGAGGACAAAATATAAT

Downstream 100 bases:

>100_bases
TAAAATCATAAATTTCAAATATAAAAGACGGCTGATTTTTCAACCGTCTTTTTTATAGAAATTTCAAAGCTTGTAATTGA
GATGAGCTTCACAATCTGTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MYLEKINGPEDVKKIKIDELPVLAQEIRDALLVRASKHGGHFGPNFGMVEATIALHYVFESPKDKIVYDVSHQSYPHKML
TGRKEAYLSEQHYDDVSGYTNPNESEHDFFTVGHTSTSVSLAAGLAKARNLKGENGNVIAVIGDGSLSGGEALEGLDFAA
ELQSNFIIIVNDNDMSIAENHGGLYQNLALLRKTDGQTECNLFKAMGLDYVYVDRGNDVAALIKAFKEVKDSTKPVVVHI
NTLKGKGYAPAEKCKEQWHYSGPFDIETGKPLFDNVEEDYSSVTCEYLLEKMKNDSSVVAITSGTPTVMGFTEDKRKEAG
SQFVDVGIAEETAVALASGIAVNGGKPFYGVYSSFVQRTFDQVSQDVCINNSPITMVIYQGSVYGMNDVTHLGFQDIPML
SNIPNLVYLAPATKEEYLAMLDWSMEQTSYPVAIKLPGGPMISDGSRVTKDFGRLNRYEVVQTGEKIAIIGLGTFFELAK
EAAKLLKEEAGINATVINPYYITGLDEALLTKLKQNHDTVITLEDGILDGGFGEKIARFYGASNMKVMNYGLKKEFLDRY
DVDAVLKENHLTAEQIVEDVLSIL

Sequences:

>Translated_584_residues
MYLEKINGPEDVKKIKIDELPVLAQEIRDALLVRASKHGGHFGPNFGMVEATIALHYVFESPKDKIVYDVSHQSYPHKML
TGRKEAYLSEQHYDDVSGYTNPNESEHDFFTVGHTSTSVSLAAGLAKARNLKGENGNVIAVIGDGSLSGGEALEGLDFAA
ELQSNFIIIVNDNDMSIAENHGGLYQNLALLRKTDGQTECNLFKAMGLDYVYVDRGNDVAALIKAFKEVKDSTKPVVVHI
NTLKGKGYAPAEKCKEQWHYSGPFDIETGKPLFDNVEEDYSSVTCEYLLEKMKNDSSVVAITSGTPTVMGFTEDKRKEAG
SQFVDVGIAEETAVALASGIAVNGGKPFYGVYSSFVQRTFDQVSQDVCINNSPITMVIYQGSVYGMNDVTHLGFQDIPML
SNIPNLVYLAPATKEEYLAMLDWSMEQTSYPVAIKLPGGPMISDGSRVTKDFGRLNRYEVVQTGEKIAIIGLGTFFELAK
EAAKLLKEEAGINATVINPYYITGLDEALLTKLKQNHDTVITLEDGILDGGFGEKIARFYGASNMKVMNYGLKKEFLDRY
DVDAVLKENHLTAEQIVEDVLSIL
>Mature_584_residues
MYLEKINGPEDVKKIKIDELPVLAQEIRDALLVRASKHGGHFGPNFGMVEATIALHYVFESPKDKIVYDVSHQSYPHKML
TGRKEAYLSEQHYDDVSGYTNPNESEHDFFTVGHTSTSVSLAAGLAKARNLKGENGNVIAVIGDGSLSGGEALEGLDFAA
ELQSNFIIIVNDNDMSIAENHGGLYQNLALLRKTDGQTECNLFKAMGLDYVYVDRGNDVAALIKAFKEVKDSTKPVVVHI
NTLKGKGYAPAEKCKEQWHYSGPFDIETGKPLFDNVEEDYSSVTCEYLLEKMKNDSSVVAITSGTPTVMGFTEDKRKEAG
SQFVDVGIAEETAVALASGIAVNGGKPFYGVYSSFVQRTFDQVSQDVCINNSPITMVIYQGSVYGMNDVTHLGFQDIPML
SNIPNLVYLAPATKEEYLAMLDWSMEQTSYPVAIKLPGGPMISDGSRVTKDFGRLNRYEVVQTGEKIAIIGLGTFFELAK
EAAKLLKEEAGINATVINPYYITGLDEALLTKLKQNHDTVITLEDGILDGGFGEKIARFYGASNMKVMNYGLKKEFLDRY
DVDAVLKENHLTAEQIVEDVLSIL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=498, Percent_Identity=24.6987951807229, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786622, Length=593, Percent_Identity=32.7150084317032, Blast_Score=317, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17539652, Length=500, Percent_Identity=23.8, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 64188; Mature: 64188

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLEKINGPEDVKKIKIDELPVLAQEIRDALLVRASKHGGHFGPNFGMVEATIALHYVFE
CCCCCCCCHHHHHHEECCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCEEHEEEEEEEEC
SPKDKIVYDVSHQSYPHKMLTGRKEAYLSEQHYDDVSGYTNPNESEHDFFTVGHTSTSVS
CCCCCEEEEECCCCCCHHHHCCCHHHHHCHHCCCCCCCCCCCCCCCCCEEEECCCCCHHH
LAAGLAKARNLKGENGNVIAVIGDGSLSGGEALEGLDFAAELQSNFIIIVNDNDMSIAEN
HHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHCCCEEEEECCCCCEEECC
HGGLYQNLALLRKTDGQTECNLFKAMGLDYVYVDRGNDVAALIKAFKEVKDSTKPVVVHI
CCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
NTLKGKGYAPAEKCKEQWHYSGPFDIETGKPLFDNVEEDYSSVTCEYLLEKMKNDSSVVA
EEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
ITSGTPTVMGFTEDKRKEAGSQFVDVGIAEETAVALASGIAVNGGKPFYGVYSSFVQRTF
EECCCCEEEECCHHHHHHCCCCEEECCCCHHHHHHHHCCEEECCCCCHHHHHHHHHHHHH
DQVSQDVCINNSPITMVIYQGSVYGMNDVTHLGFQDIPMLSNIPNLVYLAPATKEEYLAM
HHHHHCCEECCCCEEEEEECCCEECCCCCCCCCCCCCCHHHCCCCEEEECCCCHHHHHHH
LDWSMEQTSYPVAIKLPGGPMISDGSRVTKDFGRLNRYEVVQTGEKIAIIGLGTFFELAK
HCCCHHCCCCCEEEECCCCCEECCCHHHHHHHHCCCCEEEEECCCEEEEEECHHHHHHHH
EAAKLLKEEAGINATVINPYYITGLDEALLTKLKQNHDTVITLEDGILDGGFGEKIARFY
HHHHHHHHHCCCCEEEECCEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHH
GASNMKVMNYGLKKEFLDRYDVDAVLKENHLTAEQIVEDVLSIL
CCCCCEEEECCHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MYLEKINGPEDVKKIKIDELPVLAQEIRDALLVRASKHGGHFGPNFGMVEATIALHYVFE
CCCCCCCCHHHHHHEECCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCEEHEEEEEEEEC
SPKDKIVYDVSHQSYPHKMLTGRKEAYLSEQHYDDVSGYTNPNESEHDFFTVGHTSTSVS
CCCCCEEEEECCCCCCHHHHCCCHHHHHCHHCCCCCCCCCCCCCCCCCEEEECCCCCHHH
LAAGLAKARNLKGENGNVIAVIGDGSLSGGEALEGLDFAAELQSNFIIIVNDNDMSIAEN
HHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHCCCEEEEECCCCCEEECC
HGGLYQNLALLRKTDGQTECNLFKAMGLDYVYVDRGNDVAALIKAFKEVKDSTKPVVVHI
CCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
NTLKGKGYAPAEKCKEQWHYSGPFDIETGKPLFDNVEEDYSSVTCEYLLEKMKNDSSVVA
EEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
ITSGTPTVMGFTEDKRKEAGSQFVDVGIAEETAVALASGIAVNGGKPFYGVYSSFVQRTF
EECCCCEEEECCHHHHHHCCCCEEECCCCHHHHHHHHCCEEECCCCCHHHHHHHHHHHHH
DQVSQDVCINNSPITMVIYQGSVYGMNDVTHLGFQDIPMLSNIPNLVYLAPATKEEYLAM
HHHHHCCEECCCCEEEEEECCCEECCCCCCCCCCCCCCHHHCCCCEEEECCCCHHHHHHH
LDWSMEQTSYPVAIKLPGGPMISDGSRVTKDFGRLNRYEVVQTGEKIAIIGLGTFFELAK
HCCCHHCCCCCEEEECCCCCEECCCHHHHHHHHCCCCEEEEECCCEEEEEECHHHHHHHH
EAAKLLKEEAGINATVINPYYITGLDEALLTKLKQNHDTVITLEDGILDGGFGEKIARFY
HHHHHHHHHCCCCEEEECCEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHH
GASNMKVMNYGLKKEFLDRYDVDAVLKENHLTAEQIVEDVLSIL
CCCCCEEEECCHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA