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The map label for this gene is purH [H]

Identifier: 238923929

GI number: 238923929

Start: 1453056

End: 1454234

Strand: Direct

Name: purH [H]

Synonym: EUBREC_1567

Alternate gene names: 238923929

Gene position: 1453056-1454234 (Clockwise)

Preceding gene: 238923928

Following gene: 238923930

Centisome position: 42.12

GC content: 44.87

Gene sequence:

>1179_bases
ATGCAGGAATACGAATTAAAATACGGATGTAATCCAAATCAGAAACCAGCCAGAATATTTATGAAGGAGGGAGAGCTTCC
TATAAAAGTGCTTAACGGCAGAGCCGGATATATCAACTTCCTTGATGCCTTTAACGGATGGCAGCTTGTAAGAGAGCTTA
AGAAGGCAACAGGTCTTCCGGCCGCAACATCCTTCAAGCATGTTTCACCTGCAGGTGCAGCAGTAGGACAGCCACTTTCA
GATGTGGAGAAAAAGATTTACTGGGTTGATGATATGGATATTGAGTTTACACCGCTTGCAAATGCATACATCAGAGCAAG
AGGAGCTGACAGAATGTCATCATTTGGTGATTTTATTTCACTTTCAGATGTATGTGACAAGAGCACTGCACTTGTAATCA
AGAGAGAGGTATCAGACGGTGTTATCGCTCCGGGCTACACAGACGAGGCTCTTGAGATTTTAAAGGCTAAGAAAAACGGC
AATTACTGTGTTATCGAGATTGACCCGTCATATGAGCCGGCACCTATCGAGAGAAAGGATGTATTTGGCATCACATTTGA
GCAGGGCAGAAACGAGCTTCATATTGATGACGATTTCTTCTCAAATATTGTGACAGAGAACAAGGAGCTCACAGAGCAGG
CTAAGATCGATCTGGCAATCTCTATGATTACATTAAAGTATACACAGTCAAACTCTGTATGCTATGTAAAGGGCGGCCAG
GCAATCGGTATCGGAGCAGGCCAGCAGTCTCGTATCCACTGTACCAGACTTGCAGGCTCAAAGGCAGACAACTGGTGGCT
TCGTCAGTCTCCACAGGTGCTTGGACTTCAGTTCGTGGATGGTATCAGACGTGCAGACCGCGACAATACTATTGACCTTT
ATATCGGTGAGGATTATATGGATGTGCTTGCAGAGGGCGAGTGGCAGAAGTTCTTCAAGGTAAAGCCGGACGTATTTACA
GCAGAGGAGAAGAGAGCATGGCTTGACAAGAATACAGATGTAGCACTTGGATCTGATGCATTCTTCCCATTTGGTGACAA
CATTGAGCGTGCTCACAAGAGTGGCGTGAAGTATGTAGCACAGCCGGGTGGATCTGTGAGAGATGACCATGTTATTGAGA
CATGTAATAAGTACGGTATGGTAATGAGCTTTACAGGAATCAGACTTTTCCATCACTAA

Upstream 100 bases:

>100_bases
CAGGCGAGTATGAGAGCAGAATCGTAAACAAAAACAAATAAAACACTATATAAACGGTCAAATATACAAGATAAGCAGAT
AAAAACAGGAGAACAGAAAA

Downstream 100 bases:

>100_bases
TCACAAGGTATAGCGGCTATTAAGCTGAATTTAAGCACAATAAGTAATTCAATAATAGGGGACTTCATGATATAATTACA
GTATACATTTTACACAGTAG

Product: 5-aminoimidazole-4-carboxamide ribonucleotide transformylase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQEYELKYGCNPNQKPARIFMKEGELPIKVLNGRAGYINFLDAFNGWQLVRELKKATGLPAATSFKHVSPAGAAVGQPLS
DVEKKIYWVDDMDIEFTPLANAYIRARGADRMSSFGDFISLSDVCDKSTALVIKREVSDGVIAPGYTDEALEILKAKKNG
NYCVIEIDPSYEPAPIERKDVFGITFEQGRNELHIDDDFFSNIVTENKELTEQAKIDLAISMITLKYTQSNSVCYVKGGQ
AIGIGAGQQSRIHCTRLAGSKADNWWLRQSPQVLGLQFVDGIRRADRDNTIDLYIGEDYMDVLAEGEWQKFFKVKPDVFT
AEEKRAWLDKNTDVALGSDAFFPFGDNIERAHKSGVKYVAQPGGSVRDDHVIETCNKYGMVMSFTGIRLFHH

Sequences:

>Translated_392_residues
MQEYELKYGCNPNQKPARIFMKEGELPIKVLNGRAGYINFLDAFNGWQLVRELKKATGLPAATSFKHVSPAGAAVGQPLS
DVEKKIYWVDDMDIEFTPLANAYIRARGADRMSSFGDFISLSDVCDKSTALVIKREVSDGVIAPGYTDEALEILKAKKNG
NYCVIEIDPSYEPAPIERKDVFGITFEQGRNELHIDDDFFSNIVTENKELTEQAKIDLAISMITLKYTQSNSVCYVKGGQ
AIGIGAGQQSRIHCTRLAGSKADNWWLRQSPQVLGLQFVDGIRRADRDNTIDLYIGEDYMDVLAEGEWQKFFKVKPDVFT
AEEKRAWLDKNTDVALGSDAFFPFGDNIERAHKSGVKYVAQPGGSVRDDHVIETCNKYGMVMSFTGIRLFHH
>Mature_392_residues
MQEYELKYGCNPNQKPARIFMKEGELPIKVLNGRAGYINFLDAFNGWQLVRELKKATGLPAATSFKHVSPAGAAVGQPLS
DVEKKIYWVDDMDIEFTPLANAYIRARGADRMSSFGDFISLSDVCDKSTALVIKREVSDGVIAPGYTDEALEILKAKKNG
NYCVIEIDPSYEPAPIERKDVFGITFEQGRNELHIDDDFFSNIVTENKELTEQAKIDLAISMITLKYTQSNSVCYVKGGQ
AIGIGAGQQSRIHCTRLAGSKADNWWLRQSPQVLGLQFVDGIRRADRDNTIDLYIGEDYMDVLAEGEWQKFFKVKPDVFT
AEEKRAWLDKNTDVALGSDAFFPFGDNIERAHKSGVKYVAQPGGSVRDDHVIETCNKYGMVMSFTGIRLFHH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=396, Percent_Identity=56.3131313131313, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1790439, Length=279, Percent_Identity=27.5985663082437, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71985564, Length=390, Percent_Identity=53.3333333333333, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71985556, Length=420, Percent_Identity=47.1428571428571, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71985574, Length=291, Percent_Identity=57.7319587628866, Blast_Score=320, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6323056, Length=391, Percent_Identity=56.0102301790281, Blast_Score=468, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6323768, Length=389, Percent_Identity=56.8123393316195, Blast_Score=461, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24649832, Length=392, Percent_Identity=57.9081632653061, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 43897; Mature: 43897

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEYELKYGCNPNQKPARIFMKEGELPIKVLNGRAGYINFLDAFNGWQLVRELKKATGLP
CCCEEEEECCCCCCCCCEEEEECCCCCEEEECCCCCEEHHHHHCCHHHHHHHHHHHCCCC
AATSFKHVSPAGAAVGQPLSDVEKKIYWVDDMDIEFTPLANAYIRARGADRMSSFGDFIS
CCCCCCCCCCCCHHHCCCHHHHHHEEEEECCCCEEEECCCCEEEEECCCHHHHHHHCCEE
LSDVCDKSTALVIKREVSDGVIAPGYTDEALEILKAKKNGNYCVIEIDPSYEPAPIERKD
HHHHCCCCEEEEEEEECCCCEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
VFGITFEQGRNELHIDDDFFSNIVTENKELTEQAKIDLAISMITLKYTQSNSVCYVKGGQ
EEEEEHHCCCCEEEECHHHHHHHHCCCHHHHHHHHHEEEEEEEEEEEECCCCEEEEECCC
AIGIGAGQQSRIHCTRLAGSKADNWWLRQSPQVLGLQFVDGIRRADRDNTIDLYIGEDYM
EEEECCCCCCCEEEEEECCCCCCCCEECCCCCEEHHHHHHHHHHCCCCCEEEEEECCHHH
DVLAEGEWQKFFKVKPDVFTAEEKRAWLDKNTDVALGSDAFFPFGDNIERAHKSGVKYVA
HHHCCCCCHHHEECCCCEEECHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHCCCEEEE
QPGGSVRDDHVIETCNKYGMVMSFTGIRLFHH
CCCCCCCCCHHHHHHHHCCEEEEEEEEEEECC
>Mature Secondary Structure
MQEYELKYGCNPNQKPARIFMKEGELPIKVLNGRAGYINFLDAFNGWQLVRELKKATGLP
CCCEEEEECCCCCCCCCEEEEECCCCCEEEECCCCCEEHHHHHCCHHHHHHHHHHHCCCC
AATSFKHVSPAGAAVGQPLSDVEKKIYWVDDMDIEFTPLANAYIRARGADRMSSFGDFIS
CCCCCCCCCCCCHHHCCCHHHHHHEEEEECCCCEEEECCCCEEEEECCCHHHHHHHCCEE
LSDVCDKSTALVIKREVSDGVIAPGYTDEALEILKAKKNGNYCVIEIDPSYEPAPIERKD
HHHHCCCCEEEEEEEECCCCEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
VFGITFEQGRNELHIDDDFFSNIVTENKELTEQAKIDLAISMITLKYTQSNSVCYVKGGQ
EEEEEHHCCCCEEEECHHHHHHHHCCCHHHHHHHHHEEEEEEEEEEEECCCCEEEEECCC
AIGIGAGQQSRIHCTRLAGSKADNWWLRQSPQVLGLQFVDGIRRADRDNTIDLYIGEDYM
EEEECCCCCCCEEEEEECCCCCCCCEECCCCCEEHHHHHHHHHHCCCCCEEEEEECCHHH
DVLAEGEWQKFFKVKPDVFTAEEKRAWLDKNTDVALGSDAFFPFGDNIERAHKSGVKYVA
HHHCCCCCHHHEECCCCEEECHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHCCCEEEE
QPGGSVRDDHVIETCNKYGMVMSFTGIRLFHH
CCCCCCCCCHHHHHHHHCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA