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The map label for this gene is pyrP [H]

Identifier: 238923913

GI number: 238923913

Start: 1430303

End: 1431721

Strand: Direct

Name: pyrP [H]

Synonym: EUBREC_1549

Alternate gene names: 238923913

Gene position: 1430303-1431721 (Clockwise)

Preceding gene: 238923912

Following gene: 238923914

Centisome position: 41.46

GC content: 40.59

Gene sequence:

>1419_bases
ATGGAACAAAAGAAACAGGAGCCAATTCGTGATGCGAGACAGCTTGGAACGGCCAAGATGCTTATTCTTGGTTTGCAGCA
TATGTTTGCTATGTTCGGCGCAACAATTCTTGTGCCTATTCTTGTATCAGGATATTTTCAGAAGGCTTGTGGGGAGCCGC
TTACCAGAGGTCTTTCTGTATCGGTTACCCTATTTTGCGCAGGCTTTGGCACGCTTATATTTCATCTGTGTACAAAGTTT
AAGGTACCGGCTTTTTTGGGTTCGTCATTTGCTTTTTTAGGAGGCTTTTATACTGTTGCAAACCTTGACAGTGGTATGTA
TGCAGATATGGCTGTCAATGATAAGGCCGCGTATGCGTGTGGTGGAATATTTGTTGCGGGTATGCTTTATTTCGTACTTG
CACTTATCATTAAGCTGGTTGGAATTAAGCGTGTAATGCGTTTTCTTCCACCTGTAGTGACAGGACCTATTATCATATGC
ATTGGTCTTTCACTTGCCGGCTCAGCTATCAATAATGCTTCAACAAACTGGGTTCTTGCAATTATTGCACTTGGAGTTAT
AATTATTTTCAATATATGGGGAAAGGGCTTATTTAAGATCATTCCTATTCTAATGGGAGTAATTATTTCCTATGTTGTGG
CTCTTATTATGAATACTGCTGGAATTACTAATCCTGATGGTTCCGCAATTCTTGATTTTACATCAATTGCATCATCTGCG
TGGGTCGGAATACCTAAATTTCAGTTCATGAAGTTTGATATTACGTCCATTCTTGTTATGGCGCCTATCGCTGTTGCGAC
TATGATGGAGCACATTGGCGACATGTCTGCTATTTCTGCTACAGTAGAGCAGAATTTCATTGCTGATCCGGGTCTTCATA
GGACACTTATAGGTGATGGAATTGCAACTGCATTCGCAGGAGCAATCGGAGGACCGGCTAATACAACATATGGTGAGAAT
ACAGGAGTGCTTGAGCTGTCTAAGGTATATGATCCGAGAGTTATCCGTATTGCGGCTGTTTTTGCTATTGCACTTTCGTT
TATTCCAAAGTTTTCGGCTGTAATATCTACTATGCCATCAGCGATTATTGGTGGAGTTTCATTTATGCTTTATGGAATGA
TTTCAGCAATAGGAGTTAGAAATGTTGTTGAAAACAAGGTAGATCTGACTAAATCAAGAAATCTGATTATTGCAGGTGTT
ATTTTTGTATGTGGTCTTGGCTTTGGAGATGGACTGACATTTACTGTAGCAGGAACATCAATTACACTGACAGCTTTGGC
AATTGCAGCAATCGCAGGAATTTTCTTAAATGCTATTCTGCCGGGAAATGATTACGAGTTTGGAAAGAATCCTGATGGAG
ATGCAAGCAGGGGTGTGTATATGATGAACACTGACAATGATGAGGAAGAGGAATCATAG

Upstream 100 bases:

>100_bases
TTTGTAAAAAAATTATAAAAAAATAATGAAATAATAATTAAAAACTGCTATAATGTTTTCAGTTACTTATCGAAAACATT
AATTTATTAAGGAGGTTGTT

Downstream 100 bases:

>100_bases
AAGTTAATTTGTATTTAGACTGATTTGTTAGTTGTAACAGTAAATAATTTAACAAACGTTAAAAAGATATTAATAATATT
TTACTTGATAAAGTTATATA

Product: uracil permease

Products: NA

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MEQKKQEPIRDARQLGTAKMLILGLQHMFAMFGATILVPILVSGYFQKACGEPLTRGLSVSVTLFCAGFGTLIFHLCTKF
KVPAFLGSSFAFLGGFYTVANLDSGMYADMAVNDKAAYACGGIFVAGMLYFVLALIIKLVGIKRVMRFLPPVVTGPIIIC
IGLSLAGSAINNASTNWVLAIIALGVIIIFNIWGKGLFKIIPILMGVIISYVVALIMNTAGITNPDGSAILDFTSIASSA
WVGIPKFQFMKFDITSILVMAPIAVATMMEHIGDMSAISATVEQNFIADPGLHRTLIGDGIATAFAGAIGGPANTTYGEN
TGVLELSKVYDPRVIRIAAVFAIALSFIPKFSAVISTMPSAIIGGVSFMLYGMISAIGVRNVVENKVDLTKSRNLIIAGV
IFVCGLGFGDGLTFTVAGTSITLTALAIAAIAGIFLNAILPGNDYEFGKNPDGDASRGVYMMNTDNDEEEES

Sequences:

>Translated_472_residues
MEQKKQEPIRDARQLGTAKMLILGLQHMFAMFGATILVPILVSGYFQKACGEPLTRGLSVSVTLFCAGFGTLIFHLCTKF
KVPAFLGSSFAFLGGFYTVANLDSGMYADMAVNDKAAYACGGIFVAGMLYFVLALIIKLVGIKRVMRFLPPVVTGPIIIC
IGLSLAGSAINNASTNWVLAIIALGVIIIFNIWGKGLFKIIPILMGVIISYVVALIMNTAGITNPDGSAILDFTSIASSA
WVGIPKFQFMKFDITSILVMAPIAVATMMEHIGDMSAISATVEQNFIADPGLHRTLIGDGIATAFAGAIGGPANTTYGEN
TGVLELSKVYDPRVIRIAAVFAIALSFIPKFSAVISTMPSAIIGGVSFMLYGMISAIGVRNVVENKVDLTKSRNLIIAGV
IFVCGLGFGDGLTFTVAGTSITLTALAIAAIAGIFLNAILPGNDYEFGKNPDGDASRGVYMMNTDNDEEEES
>Mature_472_residues
MEQKKQEPIRDARQLGTAKMLILGLQHMFAMFGATILVPILVSGYFQKACGEPLTRGLSVSVTLFCAGFGTLIFHLCTKF
KVPAFLGSSFAFLGGFYTVANLDSGMYADMAVNDKAAYACGGIFVAGMLYFVLALIIKLVGIKRVMRFLPPVVTGPIIIC
IGLSLAGSAINNASTNWVLAIIALGVIIIFNIWGKGLFKIIPILMGVIISYVVALIMNTAGITNPDGSAILDFTSIASSA
WVGIPKFQFMKFDITSILVMAPIAVATMMEHIGDMSAISATVEQNFIADPGLHRTLIGDGIATAFAGAIGGPANTTYGEN
TGVLELSKVYDPRVIRIAAVFAIALSFIPKFSAVISTMPSAIIGGVSFMLYGMISAIGVRNVVENKVDLTKSRNLIIAGV
IFVCGLGFGDGLTFTVAGTSITLTALAIAAIAGIFLNAILPGNDYEFGKNPDGDASRGVYMMNTDNDEEEES

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=495, Percent_Identity=25.4545454545455, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI40316845, Length=495, Percent_Identity=25.4545454545455, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI44680145, Length=432, Percent_Identity=25.2314814814815, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI44680143, Length=436, Percent_Identity=25, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI87081818, Length=435, Percent_Identity=35.632183908046, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1788843, Length=428, Percent_Identity=34.1121495327103, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87082181, Length=436, Percent_Identity=25, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI87082178, Length=322, Percent_Identity=27.3291925465839, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790087, Length=448, Percent_Identity=24.1071428571429, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=445, Percent_Identity=24.0449438202247, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17541904, Length=516, Percent_Identity=22.8682170542636, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17542262, Length=424, Percent_Identity=25.7075471698113, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71993493, Length=416, Percent_Identity=23.5576923076923, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17542260, Length=224, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356175, Length=482, Percent_Identity=24.6887966804979, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49862; Mature: 49862

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]